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Muh-Hwa Yang
  • Institute of Clinical Medicine, National Yang-Ming University, Taiwan
Research fields
  • Cancer biology
Personal information

Education

Ph.D., Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 2006

M.D., Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 1994

Current position

Professor, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

Publications (since 2008)

  1. Chen, Y. W., Kao, S. Y., Wang, H. J. and Yang, M. H.* (2013). Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma. Cancer 119(24): 4259-4267.
  2. Chang, C. C., Hsu, W. H., Wang, C. C., Chou, C. H., Kuo, M. Y., Lin, B. R., Chen, S. T., Tai, S. K., Kuo, M. L. and Yang, M. H.* (2013). Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells. Cancer Res 73(13): 4147-4157.
  3. Tai, S. K., Li, W. Y., Yang, M. H., Chu, P. Y. and Wang, Y. F. (2013). Perineural invasion in t1 oral squamous cell carcinoma indicates the need for aggressive elective neck dissection. Am J Surg Pathol 37(8): 1164-1172.
  4. Lu, H. J., Chen, K. W., Chen, M. H., Chu, P. Y., Tai, S. K., Tzeng, C. H., Chang, P. M.* and Yang, M. H.* (2013). Serum albumin is an important prognostic factor for carotid blowout syndrome. Jpn J Clin Oncol 43(5): 532-539.
  5. Kuo, Y. Y., Chu, P. Y., Chang, S. Y., Wang, Y. F., Tsai, T. L., Yang, M. H., Wang, L. W. and Tai, S. K. (2013). Treatment selection for tonsillar squamous cell carcinoma. J Chin Med Assoc 76(4): 211-217.
  6. Huang, K. H., Wang, R. F., Yang, M. H., Wu, C. W., Fang, W. L., Li, A. F., Chi, C. W. and Kao, H. L. (2013). Advanced gastric cancer patients with lymphoid stroma have better survival than those without. J Surg Oncol 107(5): 523-528.
  7. Yang, W. H., Lan, H. Y., Tai, S. K. and Yang, M. H.* (2013). Repression of bone morphogenetic protein 4 by let-7i attenuates mesenchymal migration of head and neck cancer cells. Biochem Biophys Res Commun 433(1): 24-30.
  8. Chang, C. C., Yang, M. H., Lin, B. R., Chen, S. T., Pan, S. H., Hsiao, M., Lai, T. C., Lin, S. K., Jeng, Y. M., Chu, C. Y., Chen, R. H., Yang, P. C., Chin, Y. E. and Kuo, M. L. (2013). CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death Differ 20(3): 443-455.
  9. Chou, C. H., Yang, N. K., Liu, T. Y., Tai, S. K., Hsu, D. S., Chen, Y. W., Chen, Y. J., Chang, C. C., Tzeng, C. H. and Yang, M. H.* (2013). Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer Res 73(2): 953-966.
  10. Huang, K. H., Wang, R. F., Yang, M. H., Wu, C. W., Fang, W. L.*, Li, A. F., Chi, C. W. and Kao, H. L. (2013). Advanced gastric cancer patients with lymphoid stroma have better survival than those without. J Surg Oncol 107(5): 523-528.
  11. Hung, S. P., Yang, M. H., Tseng, K. F. and Lee, O. K. (2012). Hypoxia-induced Secretion of TGF-beta 1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression. Cell Transplant.
  12. Chen, Y. W., Chen, C. Y., Chiang, S. C., Lui, M. T., Kao, S. Y. and Yang, M. H.* (2012). Predictors and impact of microsurgical complications in patients with locally advanced oral squamous cell carcinoma. Cancer Sci 103(9): 1672-1678.
  13. Chua, D. T., Yiu, H. H., Seetalarom, K., Ng, A. W., Kurnianda, J., Shotelersuk, K., Krishnan, G., Hong, R. L., Yang, M. H., Wang, C. H., Sze, W. K. and Ng, W. T. (2012). Phase II trial of capecitabine plus cisplatin as first-line therapy in patients with metastatic nasopharyngeal cancer. Head Neck 34(9): 1225-1230.
  14. Huang, W. Y., Lin, C. C., Jen, Y. M., Lin, K. T., Yang, M. H., Chen, C. M., Chang, Y. N., Sung, F. C. and Kao, C. H.* (2012). Association between adult otitis media and nasopharyngeal cancer: a nationwide population-based cohort study. Radiother Oncol 104(3): 338-342.
  15. Chung, C. Y., Lin, S. F., Chen, P. M., Chang, M. C., Kao, W. Y., Chao, T. Y., Hsiao, L. T., Yen, C. C., Yang, M. H., Hwang, W. S., Lin, T. L., Chiou, T. J. and Chang, C. S*. (2012). Thalidomide for the treatment of myelodysplastic syndrome in Taiwan: results of a phase II trial. Anticancer Res 32(8): 3415-3419.
  16. Chen, Y. W., Kao, S. Y. and Yang, M. H*. (2012). Analysis of p16(INK4A) expression of oral squamous cell carcinomas in Taiwan: prognostic correlation without relevance to betel quid consumption. J Surg Oncol 106(2): 149-154.
  17. Yu, Y. B., Gau, J. P., Liu, C. Y., Yang, M. H., Chiang, S. C., Hsu, H. C., Hong, Y. C., Hsiao, L. T., Liu, J. H., Chiou, T. J., Chen, P. M., Lee, T. S., Chou, L. F., Tzeng, C. H. and Chen, T. J.* (2012). A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost 108(2): 225-235.
  18. Tai, S. K.*, Li, W. Y., Yang, M. H., Chang, S. Y., Chu, P. Y., Tsai, T. L., Wang, Y. F. and Chang, P. M. (2012). Treatment for T1-2 oral squamous cell carcinoma with or without perineural invasion: neck dissection and postoperative adjuvant therapy. Ann Surg Oncol 19(6): 1995-2002.
  19. Yang, M. H., Lin, B. R., Chang, C. H., Chen, S. T., Lin, S. K., Kuo, M. Y., Jeng, Y. M., Kuo, M. L. and Chang, C. C.* (2012). Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling. Oncogene 31(19): 2401-2411.
  20. Yang, W. H., Lan, H. Y., Huang, C. H., Tai, S. K., Tzeng, C. H., Kao, S. Y., Wu, K. J., Hung, M. C. and Yang, M. H.* (2012). RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol 14(4): 366-374.
  21. Li, C. W., Xia, W., Huo, L., Lim, S. O., Wu, Y., Hsu, J. L., Chao, C. H., Yamaguchi, H., Yang, N. K., Ding, Q., Wang, Y., Lai, Y. J., LaBaff, A. M., Wu, T. J., Lin, B. R., Yang, M. H., Hortobagyi, G. N. and Hung, M. C.* (2012). Epithelial-mesenchymal transition induced by TNF-alpha requires NF-kappaB-mediated transcriptional upregulation of Twist1. Cancer Res 72(5): 1290-1300.
  22. Chen, K. W., Liu, C. J., Lu, H. J., Tzeng, C. H., Liu, J. H., Chiou, T. J., Yen, C. C., Wang, W. S., Chao, T. C., Teng, H. W., Chen, M. H., Liu, C. Y., Chang, P. M. and Yang, M. H. (2012). Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study. BMC Res Notes 5: 70.
  23. Lu, H. J., Chen, K. W., Tzeng, C. H., Liu, J. H., Chiou, T. J., Yen, C. C., Chao, T. C., Teng, H. W., Chen, M. H., Liu, C. Y., Wang, W. S., Chang, P. M. and Yang, M. H. (2012). Evaluation of prognosis for carcinoma of unknown origin in elderly patients. Oncology 83(1): 24-30.
  24. Wu, K. J. and Yang, M. H. (2011). Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection. Biosci Rep 31(6): 449-455.
  25. Chang, P. M., Tzeng, C. H., Chen, M. H., Tsao, C. J., Su, W. C., Hwang, W. S., Chang, Y. F., Chang, S. Y. and Yang, M. H.* (2011). Triweekly reduced-dose docetaxel combined with cisplatin in recurrent/metastatic head and neck squamous cell carcinoma: a multicenter phase II study. Cancer Chemother Pharmacol 68(6): 1477-1484.
  26. Hsieh, Y. Y., Mu-Hsin Chang, P., Chen, M. H., Chu, P. Y., Tzeng, C. H., Chang, S. Y., Chen, P. M. and Yang, M. H.* (2011). Pretreatment risk stratification for non-metastatic head and neck squamous cell carcinoma in a high-prevalence area. J Chin Med Assoc 74(11): 487-492.
  27. Tsai, T. L., Chu, P. Y., Tai, S. K., Wang, Y. F., Yang, M. H., Wang, L. W., Lirng, J. F. and Chang, S. Y.* (2011). Promising long-term results with attenuated adverse effects by methotrexate-containing sequential chemoradiation therapy in locally advanced head and neck squamous cell carcinoma. Jpn J Clin Oncol 41(10): 1182-1193.
  28. Wu, M. Z., Tsai, Y. P., Yang, M. H., Huang, C. H., Chang, S. Y., Chang, C. C., Teng, S. C. and Wu, K. J. (2011). Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol Cell 43(5): 811-822.
  29. Pan, J. J. and Yang, M. H.* (2011). The role of epithelial-mesenchymal transition in pancreatic cancer. J Gastrointest Oncol 2(3): 151-156.
  30. Hwang, W. L., Yang, M. H., Tsai, M. L., Lan, H. Y., Su, S. H., Chang, S. C., Teng, H. W., Yang, S. H., Lan, Y. T., Chiou, S. H.* and Wang, H. W.* (2011). SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology 141(1): 279-291, 291 e271-275.
  31. Huang, Y. C., Chang, P. M., Chen, M. H., Chu, P. Y., Tzeng, C. H., Chang, S. Y. and Yang, M. H.* (2011). A study using ifosfamide and etoposide in patients with cisplatin-refractory recurrent or metastatic head and neck squamous cell carcinoma. Jpn J Clin Oncol 41(5): 630-636.
  32. Tai, S. K., Yang, M. H., Chang, S. Y., Chang, Y. C., Li, W. Y., Tsai, T. L., Wang, Y. F., Chu, P. Y. and Hsieh, S. L.* (2011). Persistent Kruppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci 102(4): 895-902.
  33. Lo, T., Ho, J. H., Yang, M. H. and Lee, O. K.* (2011). Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells. Cell Transplant 20(6): 813-825.
  34. Yang, D. C., Yang, M. H., Tsai, C. C., Huang, T. F., Chen, Y. H. and Hung, S. C. (2011). Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS ONE 6(9): e23965.
  35. Chen, Y. J., Li, H. Y., Huang, C. H., Twu, N. F., Yen, M. S., Wang, P. H., Chou, T. Y., Liu, Y. N., Chao, K. C. and Yang, M. H.* (2010). Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. J Pathol 222(3): 261-270.
  36. Yang, M. H.*+, Hsu, D. S., Wang, H. W., Wang, H. J., Lan, H. Y., Yang, W. H., Huang, C. H., Kao, S. Y., Tzeng, C. H., Tai, S. K., Chang, S. Y., Lee, O. K. and Wu, K. J.* (2010). Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 12(10): 982-992.
  37. Chen, M. H., Chang, P. M., Chen, P. M., Tzeng, C. H., Chu, P. Y., Chang, S. Y. and Yang, M. H.* (2010). Prolonged facial edema is an indicator of poor prognosis in patients with head and neck squamous cell carcinoma. Support Care Cancer 18(10): 1313-1319.
  38. Yang, J. M., Hung, C. M., Fu, C. N., Lee, J. C., Huang, C. H., Yang, M. H., Lin, C. L., Kao, J. Y. and Way, T. D. (2010). Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. J Agric Food Chem 58(18): 10020-10026.
  39. Hsu, D. S., Lan, H. Y., Huang, C. H., Tai, S. K., Chang, S. Y., Tsai, T. L., Chang, C. C., Tzeng, C. H., Wu, K. J., Kao, J. Y.* and Yang, M. H.* (2010). Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer. Clin Cancer Res 16(18): 4561-4571.
  40. Huang, Y. C., Chang, P. M., Lee, I. C., Yang, C. F., Tzeng, C. H. and Yang, M. H.* (2010). Duodenal squamous cell carcinoma derived from the hypopharynx: immunohistochemical assessment of metastatic mechanisms. Gastrointest Endosc 72(2): 460-463.
  41. Chen, Y. W., Yang, M. H., Kao, S. Y. and Wu, C. H. (2010). A rare complication of acquired factor VIII inhibitors in a postoperative oral cancer patient: a case report. J Oral Maxillofac Surg 68(8): 1989-1993.
  42. Chang, P. M., Hsieh, Y. Y., Chen, M. H., Tzeng, C. H., Chu, P. Y., Chang, S. Y., Chen, P. M. and Yang, M. H.* (2010). Cetuximab-based therapy in recurrent/metastatic head and neck squamous cell carcinoma: experience from an area in which betel nut chewing is popular. J Chin Med Assoc 73(6): 292-299.
  43. Huang, C. H., Chen, P. M., Lu, T. C., Kung, W. M., Chiou, T. J., Yang, M. H., Kao, J. Y. and Wu, K. J. (2010). Purified recombinant TAT-homeobox B4 expands CD34(+) umbilical cord blood and peripheral blood progenitor cells ex vivo. Tissue Eng Part C Methods 16(3): 487-496.
  44. Hsu, D. S., Chang, S. Y., Liu, C. J., Tzeng, C. H., Wu, K. J., Kao, J. Y.* and Yang, M. H.* (2010). Identification of increased NBS1 expression as a prognostic marker of squamous cell carcinoma of the oral cavity. Cancer Sci 101(4): 1029-1037.
  45. Yang, M. H., Chang, P. M., Tzeng, C. H., Chang, S. Y., Chu, P. Y., Tai, S. K., Tsai, T. L., Wang, Y. F., Huang, J. L., Wang, H. M.* and Chen, P. M.* (2010). Promising overall survival of patients with recurrent/metastatic squamous cell carcinoma of head and neck receiving gemcitabine plus cisplatin treatment: report of a multi-center phase II study. Cancer Chemother Pharmacol 65(2): 259-265.
  46. Hsieh, Y.Y. and Yang, M.H.* (2009). Deep into the Cancer Metastasis and Development: TWIST Activation by Hypoxia-Inducible Factor-1. J Chinese Oncol. Soc. 25(5): 317-325.
  47. Chen, M. H., Chang, P. M., Chen, P. M., Tzeng, C. H., Chu, P. Y., Chang, S. Y. and Yang, M. H.* (2009). Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer. J Cancer Res Clin Oncol 135(12): 1783-1790.
  48. Huang, C. H., Yang, W. H., Chang, S. Y., Tai, S. K., Tzeng, C. H., Kao, J. Y., Wu, K. J. and Yang, M. H.* (2009). Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. Neoplasia 11(12): 1371-1382.
  49. Hung, J. J., Yang, M. H., Hsu, H. S., Hsu, W. H., Liu, J. S. and Wu, K. J. (2009). Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax 64(12): 1082-1089.
  50. Yang, M. H., Chen, C. L., Chau, G. Y., Chiou, S. H., Su, C. W., Chou, T. Y., Peng, W. L. and Wu, J. C. (2009). Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50(5): 1464-1474.
  51. Tsai, Y. P., Yang, M. H., Huang, C. H., Chang, S. Y., Chen, P. M., Liu, C. J., Teng, S. C. and Wu, K. J.* (2009). Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis 30(6): 1049-1057.
  52. Liu, C. Y., Huang, L. J., Wang, W. S., Chen, T. L., Yen, C. C., Yang, M. H., Hsiao, L. T., Chen, P. M. and Chiou, T. J.* (2009). Candidemia in cancer patients: impact of early removal of non-tunneled central venous catheters on outcome. J Infect 58(2): 154-160.
  53. Chang, P. M., Chen, P. M., Chu, P. Y., Wang, L. W., Tai, S. K., Tsai, T. L., Huang, J. L., Wang, Y. F., Chang, S. Y.* and Yang, M. H.* (2008). Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study. Cancer Chemother Pharmacol 63(1): 9-17.
  54. Chang, P. M., Chen, P. M., Hsieh, S. L., Tzeng, C. H., Liu, J. H., Chiou, T. J., Wang, W. S., Yen, C. C., Gau, J. P. and Yang, M. H.* (2008). Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome. Int J Oncol 33(3): 549-554.
  55. Tai, S. K., Yang, M. H., Wang, L. W., Tsai, T. L., Chu, P. Y., Wang, Y. F., Huang, J. L. and Chang, S. Y.* (2008). Chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer. Jpn J Clin Oncol 38(8): 521-527.
  56. Yang, M. H. and Wu, K. J.* (2008). TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 7(14): 2090-2096.
  57. Chang, P. M., Teng, H. W., Chen, P. M., Chang, S. Y., Chu, P. Y., Tsai, T. L., Tai, S. K., Wang, Y. F., Huang, J. L. and Yang, M. H.* (2008). Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer. J Chin Med Assoc 71(7): 336-341.
  58. Chen, P. M., Yen, C. C., Wang, W. S., Lin, Y. J., Chu, C. J., Chiou, T. J., Liu, J. H. and Yang, M. H.* (2008). Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia. Int J Oncol 32(6): 1335-1341.
  59. Lee, M. Y., Chiou, T. J., Hsiao, L. T., Yang, M. H., Lin, P. C., Poh, S. B., Yen, C. C., Liu, J. H., Teng, H. W., Chao, T. C., Wang, W. S. and Chen, P. M. (2008). Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin's lymphoma patients receiving autologous hematopoietic stem cell transplantation. Ann Hematol 87(4): 285-289.
  60. Chen, Y. C., Chiang, H. Y., Yang, M. H., Chen, P. M., Chang, S. Y., Teng, S. C., Vanhaesebroeck, B. and Wu, K. J.* (2008). Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. J Mol Med (Berl) 86(4): 401-412.
  61. Chu, Z., Chen, J. S., Liau, C. T., Wang, H. M., Lin, Y. C., Yang, M. H., Chen, P. M., Gardner, E. R., Figg, W. D. and Sparreboom, A. (2008). Oral bioavailability of a novel paclitaxel formulation (Genetaxyl) administered with cyclosporin A in cancer patients. Anticancer Drugs 19(3): 275-281.
  62. Yang, M. H.+, Wu, M. Z.+, Chiou, S. H., Chen, P. M., Chang, S. Y., Liu, C. J., Teng, S. C. and Wu, K. J.* (2008). Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10(3): 295-305.
  63. Lin, S. C., Kau, H. C., Yang, C. F., Yang, M. H., Tsai, C. C., Kao, S. C. and Hsu, W. M. (2008). Adenoid cystic carcinoma arising in the inferior orbit without evidence of lacrimal gland involvement. Ophthal Plast Reconstr Surg 24(1): 74-76.

    * Corresponding author
    + Equal contirbution







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