Education

Ph.D., Technical University of Graz, 1986

Lab information

Group Leader Max F Perutz Laboratories, Department of Medical Biochemistry
Medical University Vienna, Austria

The Kuchler Lab studies fundamental problems in infection biology using a combination of molecular as well as genome-wide and systems biology approaches. They are particularly interested in a better understanding of the dynamic gene regulation during host-pathogen interplay, with a focus on fungal pathogens such as Candida spp.

More detail about Kuchler can be found at
https://tissuehome.meduniwien.ac.at/faculty/karl-kuchler/

Research focus

Karl Kuchler has a long-standing interest in fungal infection biology, molecular genetics, as well as host immune signaling at their intersections with the molecular mechanisms of antifungal drug resistance. His work discovered a novel TLR7-dependent fungal response pathway in dendritic cells, and the group discovered a molecular mechanism underlying the hyper-inflammatory host response upon fungal infections. Finally, the most work uncovered pivotal roles of fungal HDACs/HATs in controlling antifungal drug resistance, stress response, DNA repair as well as virulence.

Publications