Michael Riedelberger Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, Medical University of Vienna
1 protocol

Sabrina Jenull Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
1 protocol

Miha Tome Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia
1 protocol

Fabian Istel Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
4 protocols

Advisor
Karl Kuchler
  • Professor of Molecular genetics, Medical University of Vienna, Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, A-1030 Vienna
Research focus
  • Molecular biology
  • Karl Kuchler has a long-standing interest in fungal infection biology, molecular genetics, as well as host immune signaling at their intersections with the molecular mechanisms of antifungal drug resistance. His work discovered a novel TLR7-dependent fungal response pathway in dendritic cells, and the group discovered a molecular mechanism underlying the hyper-inflammatory host response upon fungal infections. Finally, the most work uncovered pivotal roles of fungal HDACs/HATs in controlling antifungal drug resistance, stress response, DNA repair as well as virulence.
  • 6 Author merit

Education

Ph.D., Technical University of Graz, 1986

Lab information

Group Leader Max F Perutz Laboratories, Department of Medical Biochemistry
Medical University Vienna, Austria

The Kuchler Lab studies fundamental problems in infection biology using a combination of molecular as well as genome-wide and systems biology approaches. They are particularly interested in a better understanding of the dynamic gene regulation during host-pathogen interplay, with a focus on fungal pathogens such as Candida spp.

More detail about Kuchler can be found at
https://tissuehome.meduniwien.ac.at/faculty/karl-kuchler/

Publications

6 Protocols published
Analyzing the Quenchable Iron Pool in Murine Macrophages by Flow Cytometry
Authors:  Michael Riedelberger and Karl Kuchler, date: 03/20/2020, view: 3662, Q&A: 0
Tissue-resident macrophages are pivotal for a tightly-regulated iron metabolism at a cellular and systemic level, since subtle iron alterations increase the susceptibility for microbial infections or drive multiple diseases. However, research on ...
Phenotypic Profiling of Candida glabrata in Liquid Media
Authors:  Fabian Istel, Miha Tome, Sabrina Jenull and Karl Kuchler, date: 04/05/2017, view: 9594, Q&A: 0
Here, we describe a method for a large-scale liquid screening approach in C. glabrata. This liquid media method offers several distinct advantages over solid media approaches. This includes growth measurement on a plate reader instead of ...
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