Karl Kuchler Medical University of Vienna, Center for Biochemistry, Max Perutz Labs Campus Biocenter, A-1030

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Michael Riedelberger Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, Medical University of Vienna
1 protocol

Sabrina Jenull Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
1 protocol

Miha Tome Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia
1 protocol

Fabian Istel Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry, Austria
4 protocols

Advisor

Karl Kuchler

Professor of Molecular genetics, Medical University of Vienna, Center for Medical Biochemistry, Max Perutz Labs Vienna, Campus Vienna Biocenter, A-1030 Vienna

Research focus

Molecular biology
Karl Kuchler has a long-standing interest in fungal infection biology, molecular genetics, as well as host immune signaling at their intersections with the molecular mechanisms of antifungal drug resistance. His work discovered a novel TLR7-dependent fungal response pathway in dendritic cells, and the group discovered a molecular mechanism underlying the hyper-inflammatory host response upon fungal infections. Finally, the most work uncovered pivotal roles of fungal HDACs/HATs in controlling antifungal drug resistance, stress response, DNA repair as well as virulence.

6 Author merit
Reviewer merit
Editor merit

Education

Ph.D., Technical University of Graz, 1986

Lab information

Group Leader Max F Perutz Laboratories, Department of Medical Biochemistry
Medical University Vienna, Austria

The Kuchler Lab studies fundamental problems in infection biology using a combination of molecular as well as genome-wide and systems biology approaches. They are particularly interested in a better understanding of the dynamic gene regulation during host-pathogen interplay, with a focus on fungal pathogens such as Candida spp.

More detail about Kuchler can be found at
https://tissuehome.meduniwien.ac.at/faculty/karl-kuchler/

Publications

https://pubmed.ncbi.nlm.nih.gov/?term=Kuchler,+Karl+[Author]

6 Protocols published

Analyzing the Quenchable Iron Pool in Murine Macrophages by Flow Cytometry

Authors: Michael Riedelberger and Karl Kuchler, date: 03/20/2020, view: 3662, Q&A: 0

Tissue-resident macrophages are pivotal for a tightly-regulated iron metabolism at a cellular and systemic level, since subtle iron alterations increase the susceptibility for microbial infections or drive multiple diseases. However, research on ...

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Phenotypic Profiling of Candida glabrata in Liquid Media

Authors: Fabian Istel, Miha Tome, Sabrina Jenull and Karl Kuchler, date: 04/05/2017, view: 9594, Q&A: 0

Here, we describe a method for a large-scale liquid screening approach in C. glabrata. This liquid media method offers several distinct advantages over solid media approaches. This includes growth measurement on a plate reader instead of ...

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