Ana Gómez Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
1 protocol

Fátima Martín-Sánchez Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
1 protocol

Adriano Jménez-Escrig Medicina y Especialidades Médicas, Universidad de Alcalá, Spain
1 protocol

María Montero-Vega Neurobiology Service, Hospital Ramón y Cajal, Spain
1 protocol

Pablo Pelegrín
  • Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
Research focus
  • Immunology
  • 2 Author merit


Ph.D. in Cell Biology Department, Murcia University, Spain 2003

Current position

Group Leader at Murcia Biomedical Research Institute (IMIB), Murcia’s Biomedical Research Institute, Spain.


  1. Baroja-Mazo, A., Barbera-Cremades, M. and Pelegrin, P. (2013). The participation of plasma membrane hemichannels to purinergic signaling. Biochim Biophys Acta 1828(1): 79-93. (JIF 4.647; 4 citations)
  2. Compan, V., Baroja-Mazo, A., Lopez-Castejon, G., Gomez, A. I., Martinez, C. M., Angosto, D., Montero, M. T., Herranz, A. S., Bazan, E., Reimers, D., Mulero, V. and Pelegrin, P. (2012). Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37(3): 487-500.
  3. Compan, V., Baroja-Mazo, A., Bragg, L., Verkhratsky, A., Perroy, J. and Pelegrin, P. (2012). A genetically encoded IL-1beta bioluminescence resonance energy transfer sensor to monitor inflammasome activity. J Immunol 189(5): 2131-2137. (JIF 5.745; 0 citations)
  4. Lopez-Castejon, G. and Pelegrin, P. (2012). Current status of inflammasome blockers as anti-inflammatory drugs. Expert Opin Investig Drugs 21(7): 995-1007. (JIF 4.337; 0 citations)
  5. Barbera-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F. and Pelegrin, P. (2012). P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release. FASEB J 26(7): 2951-2962. (JIF 6.515; 2 citations)
  6. Machado-Linde, F.*, Pelegrin, P.*, Sanchez-Ferrer, M. L., Leon, J., Cascales, P. and Parrilla, J. J. (2012). 2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential. Reprod Sci 19(10): 1018-1029. (JIF 2.444; 0 citations)
  7. Baroja-Mazo, A. and Pelegrin, P. (2012). Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates. J Osteoporos 2012: 408242.
  8. Roger, S. and Pelegrin, P. (2011). P2X7 receptor antagonism in the treatment of cancers. Expert Opin Investig Drugs 20(7): 875-880. (JIF 4.337; 2 citations)
  9. Pelegrin, P. (2011). Many ways to dilate the P2X7 receptor pore. Br J Pharmacol 163(5): 908-911. (JIF 4.337; 4 citations)
  10. Lopez-Castejon, G.*, Baroja-Mazo, A.* and Pelegrin, P. (2011). Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules. Cell Mol Life Sci 68(18): 3095-3107. (JIF 7.047; 5 citations)
  11. Keating, C.*, Pelegrin, P.*, Martinez, C. M. and Grundy, D. (2011). P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome. J Immunol 187(3): 1467-1474. (JIF 5.745; 3 citations)
  12. Roger, S., Gillet, L., Baroja-Mazo, A., Surprenant, A. and Pelegrin, P. (2010). C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation. J Biol Chem 285(23): 17514-17524. (JIF 5.328; 12 citations)
  13. Pelegrin, P. and Surprenant, A. (2009). Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates. EMBO J 28(14): 2114-2127.
  14. Pelegrin, P. and Surprenant, A. (2009). The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release. Purinergic Signal 5(2): 129-137. (JIF 3.764; 39 citations).
  15. Pelegrin, P. (2008). Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1. Drug News Perspect 21(8): 424-433. (JIF 2.598; 14 citations)
  16. Pelegrin, P., Barroso-Gutierrez, C. and Surprenant, A. (2008). P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180(11): 7147-7157. (JIF 5.745; 82 citations)
  17. Pelegrin, P. and Surprenant, A. (2007). Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem 282(4): 2386-2394. (JIF 5.328; 125 citations)
  18. Young, M. T.*, Pelegrin, P.* and Surprenant, A. (2007). Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol 71(1): 92-100. (JIF 4.725; 42 citations) Page 4 of 9
  19. Pelegrin, P. and Surprenant, A. (2006). Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 25(21): 5071-5082.
  20. Young, M. T.*, Pelegrin, P.* and Surprenant, A. (2006). Identification of Thr283 as a key determinant of P2X7 receptor function. Br J Pharmacol 149(3): 261-268. (JIF 4.925; 18 citations)
  21. Chaves-Pozo, E.*, Pelegrin, P.*, Garcia-Castillo, J., Garcia-Ayala, A., Mulero, V. and Meseguer, J. (2004). Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum. Cell Tissue Res 316(2): 189-195. (JIF 2.804; 23 citations)
  22. Pelegrin, P., Chaves-Pozo, E., Mulero, V. and Meseguer, J. (2004). Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream. Dev Comp Immunol 28(3): 229-237. (JIF 3.293; 36 citations)
  23. Pelegrin, P., Garcia-Castillo, J., Mulero, V. and Meseguer, J. (2001). Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines. Cytokine 16(2): 67-72. (JIF 3.532; 46 citations)

2 Protocols published
Isolation of Particles of Recombinant ASC and NLRP3
Authors:  Fátima Martín-Sánchez, Ana I. Gómez and Pablo Pelegrín, date: 05/20/2015, view: 11196, Q&A: 0
NLRP3 inflammasome is a multiprotein complex responsible for the activation of inflammatory caspase-1, resulting in processing and release of pro-inflammatory cytoquines IL-1β and IL-18 (Schroder and Tschopp, 2010). This inflammasome is composed of ...
Evaluation of Caspase-1 Activation and IL-1β Production in A Kainic Acid Microdyalisis Brain Injury Model
Intracerebral infusion of kainic acid (KA) by a microdialysis probe induces a focal swelling in the brain-perfused area which promotes inflammation (Compan et al., 2012; Oprica et al., 2003). The microdialysis technique allows the ...
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