Georg Schett Department of Internal Medicine 3, University of Erlangen-Nuremberg, Institute of Rheumatology and Immunology, Germany
1 protocol

Carina Scholtysek Department of Internal Medicine 3, University of Erlangen-Nuremberg, Institute of Rheumatology and Immunology, Germany
1 protocol

Gerhard Krönke
  • Department of Internal Medicine 3, University of Erlangen-Nuremberg, Institute of Rheumatology and Immunology, Germany
Research focus
  • Cancer biology
  • 1 Author merit


M.D., Medical School at the University of Vienna, Austria, 2002

Current position

Attending Physician at the Department of Internal Medicine 3 at the University of Erlangen, Germany (2013-present)
Principal Investigator at the Department of Internal Medicine 3 at the University of Erlangen, Germany (2008-present)


Original research articles

  1. Lauber, K., Keppeler, H., Munoz, L. E., Koppe, U., Schroder, K., Yamaguchi, H., Krönke, G., Uderhardt, S., Wesselborg, S., Belka, C., Nagata, S. and Herrmann, M. (2013). Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids. Cell Death Differ 20(9): 1230-1240.
  2. Scholtysek, C., Katzenbeisser, J., Fu, H., Uderhardt, S., Ipseiz, N., Stoll, C., Zaiss, M. M., Stock, M., Donhauser, L., Bohm, C., Kleyer, A., Hess, A., Engelke, K., David, J. P., Djouad, F., Tuckermann, J. P., Desvergne, B., Schett, G. and Krönke, G. (2013). PPARbeta/delta governs Wnt signaling and bone turnover. Nat Med 19(5): 608-613.
  3. Lin, N. Y., Beyer, C., Giessl, A., Kireva, T., Scholtysek, C., Uderhardt, S., Munoz, L. E., Dees, C., Distler, A., Wirtz, S., Krönke, G., Spencer, B., Distler, O., Schett, G. and Distler, J. H. (2013). Autophagy regulates TNFalpha-mediated joint destruction in experimental arthritis. Ann Rheum Dis 72(5): 761-768.
  4. Kleyer, A., Scholtysek, C., Bottesch, E., Hillienhof, U., Beyer, C., Distler, J. H., Tuckermann, J. P., Schett, G. and Krönke, G. (2012). Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res 27(12): 2442-2451.
  5. Uderhardt, S., Herrmann, M., Oskolkova, O. V., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R., Nimmerjahn, F., Bochkov, V. N., Schett, G. and Krönke, G. (2012). 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity 36(5): 834-846.
  6. Schwab, I., Biburger, M., Krönke, G., Schett, G. and Nimmerjahn, F. (2012). IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol 42(4): 826-830.
  7. Krönke, G., Reich, N., Scholtysek, C., Akhmetshina, A., Uderhardt, S., Zerr, P., Palumbo, K., Lang, V., Dees, C., Distler, O., Schett, G. and Distler, J. H. (2012). The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. Ann Rheum Dis 71(6): 1081-1087.
  8. Dees, C., Akhmetshina, A., Zerr, P., Reich, N., Palumbo, K., Horn, A., Jungel, A., Beyer, C., Krönke, G., Zwerina, J., Reiter, R., Alenina, N., Maroteaux, L., Gay, S., Schett, G., Distler, O. and Distler, J. H. (2011). Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med 208(5): 961-972.
  9. Krönke, G., Uderhardt, S., Kim, K. A., Stock, M., Scholtysek, C., Zaiss, M. M., Surmann-Schmitt, C., Luther, J., Katzenbeisser, J., David, J. P., Abdollahi-Roodsaz, S., Tran, K., Bright, J. M., Binnerts, M. E., Akhmetshina, A., Bohm, C., Distler, J. H., Joosten, L. A., Schett, G. and Abo, A. (2010). R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum 62(8): 2303-2312.
  10. Uderhardt, S., Diarra, D., Katzenbeisser, J., David, J. P., Zwerina, J., Richards, W., Krönke, G. and Schett, G. (2010). Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis 69(3): 592-597.
  11. Stach, C. M., Bauerle, M., Englbrecht, M., Krönke, G., Engelke, K., Manger, B. and Schett, G. (2010). Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum 62(2): 330-339.
  12. Bohm, C., Hayer, S., Kilian, A., Zaiss, M. M., Finger, S., Hess, A., Engelke, K., Kollias, G., Krönke, G., Zwerina, J., Schett, G. and David, J. P. (2009). The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol 183(9): 5938-5947.
  13. Zarbock, A., Distasi, M. R., Smith, E., Sanders, J. M., Krönke, G., Harry, B. L., von Vietinghoff, S., Buscher, K., Nadler, J. L. and Ley, K. (2009). Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol 183(7): 4715-4722.
  14. , G., Stolina, M., Dwyer, D., Zack, D., Uderhardt, S., Krönke, G., Kostenuik, P. and Feige, U. (2009). Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis. Arthritis Rheum 60(9): 2644-2654.
  15. Axmann, R., Bohm, C., Krönke, G., Zwerina, J., Smolen, J. and Schett, G. (2009). Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. Arthritis Rheum 60(9): 2747-2756.
  16. Krönke, G., Katzenbeisser, J., Uderhardt, S., Zaiss, M. M., Scholtysek, C., Schabbauer, G., Zarbock, A., Koenders, M. I., Axmann, R., Zwerina, J., Baenckler, H. W., van den Berg, W., Voll, R. E., Kuhn, H., Joosten, L. A. and Schett, G. (2009). 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol 183(5): 3383-3389.
  17. Krönke, G., Uderhardt, S., Katzenbeisser, J. and Schett, G. (2009). The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity 42(4): 383-385.
  18. Herman, S., Muller, R. B., Krönke, G., Zwerina, J., Redlich, K., Hueber, A. J., Gelse, H., Neumann, E., Muller-Ladner, U. and Schett, G. (2008). Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. Arthritis Rheum 58(10): 3041-3050.
  19. Polzer, K., Soleiman, A., Baum, W., Axmann, R., Distler, J., Redlich, K., Kilian, A., Krönke, G., Schett, G. and Zwerina, J. (2008). Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha. Ann Rheum Dis 67(5): 602-608.
  20. Zwerina, J., Redlich, K., Polzer, K., Joosten, L., Krönke, G., Distler, J., Hess, A., Pundt, N., Pap, T., Hoffmann, O., Gasser, J., Scheinecker, C., Smolen, J. S., van den Berg, W. and Schett, G. (2007). TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci U S A 104(28): 11742-11747.
  21. Gruber, F., Oskolkova, O., Leitner, A., Mildner, M., Mlitz, V., Lengauer, B., Kadl, A., Mrass, P., Krönke, G., Binder, B. R., Bochkov, V. N., Leitinger, N. and Tschachler, E. (2007). Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells. J Biol Chem 282(23): 16934-16941.
  22. Krönke, G., Kadl, A., Ikonomu, E., Bluml, S., Furnkranz, A., Sarembock, I. J., Bochkov, V. N., Exner, M., Binder, B. R. and Leitinger, N. (2007). Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol 27(6): 1276-1282.
  23. Holzer, G., Esterbauer, H., Krönke, G., Exner, M., Kopp, C. W., Leitinger, N., Wagner, O., Gmeiner, B. M. and Kapiotis, S. (2007). The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC. Thromb Res 120(1): 71-79.
  24. Isakson, B. E., Krönke, G., Kadl, A., Leitinger, N. and Duling, B. R. (2006). Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication. Arterioscler Thromb Vasc Biol 26(10): 2216-2221.
  25. Bluml, S., Kirchberger, S., Bochkov, V. N., Krönke, G., Stuhlmeier, K., Majdic, O., Zlabinger, G. J., Knapp, W., Binder, B. R., Stockl, J. and Leitinger, N. (2005). Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40. J Immunol 175(1): 501-508.
  26. Furnkranz, A., Schober, A., Bochkov, V. N., Bashtrykov, P., Krönke, G., Kadl, A., Binder, B. R., Weber, C. and Leitinger, N. (2005). Oxidized phospholipids trigger atherogenic inflammation in murine arteries. Arterioscler Thromb Vasc Biol 25(3): 633-638.
  27. Krönke, G., Bochkov, V. N., Huber, J., Gruber, F., Bluml, S., Furnkranz, A., Kadl, A., Binder, B. R. and Leitinger, N. (2003). Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J Biol Chem 278(51): 51006-51014.
  28. Uhrin, P., Dewerchin, M., Hilpert, M., Chrenek, P., Schofer, C., Zechmeister-Machhart, M., Krönke, G., Vales, A., Carmeliet, P., Binder, B. R. and Geiger, M. (2000). Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106(12): 1531-1539.

Review articles

  1. Uderhardt, S. and Krönke, G. (2012). 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J Mol Med (Berl) 90(11): 1247-1256.
  2. Scholtysek, C., Krönke, G. and Schett, G. (2012). Inflammation-associated changes in bone homeostasis. Inflamm Allergy Drug Targets 11(3): 188-195.
  3. Herman, S., Krönke, G. and Schett, G. (2008). Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends Mol Med 14(6): 245-253.
  4. Krönke, G. and Leitinger, N. (2006). Oxidized phospholipids at the interface of innate and adaptive immunity. Future Lipidology 1(5): 623-630.
1 Protocol published
Bone Resorption Assay
Authors:  Carina Scholtysek, Gerhard Krönke and Georg Schett, date: 07/20/2014, view: 15287, Q&A: 0
The Bone resorption assay provides an easy to use protocol for quantitatively measuring in vitro osteoclast-mediated bone resorption. Osteoclasts can be seeded onto the bone slices and formation of resorption pits can be quantified via ...
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