Alexandros Alexandratos National and Kapodistrian University of Athens
66 protocols

Gal Haimovich Weizmann Institute of Science Rehovot
132 protocols

21 protocols

Jia Li SRI International
51 protocols

Abhijit Kale
  • Product application scientist, LevitasBio
Research focus
  • senescence, Immune system , aging


Ph.D., Albert Einstein college of medicine, 2012

Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. PubMed PMID: 33199924; PubMed Central PMCID: PMC7908681.

Kale A, Sharma A, Stolzing A, Desprez PY, Campisi J. Role of immune cells in the removal of deleterious senescent cells. Immun Ageing. 2020;17:16. doi: 10.1186/s12979-020-00187-9. eCollection 2020. Review. PubMed PMID: 32518575; PubMed Central PMCID: PMC7271494.

Basisty N, Kale A, Patel S, Campisi J, Schilling B. The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications. Expert Rev Proteomics. 2020 Apr;17(4):297-308. doi: 10.1080/14789450.2020.1766976. Epub 2020 May 19. Review. PubMed PMID: 32425074; PubMed Central PMCID: PMC7416420.

Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 2020 Jan;18(1):e3000599. doi: 10.1371/journal.pbio.3000599. eCollection 2020 Jan. PubMed PMID: 31945054; PubMed Central PMCID: PMC6964821.

Kale A, Baker NE. Tumor evolution: Multiple induction mechanisms for cell competition. Mol Cell Oncol. 2018;5(5):e1481812. doi: 10.1080/23723556.2018.1481812. eCollection 2018. PubMed PMID: 30263943; PubMed Central PMCID: PMC6154854.

Kale A, Ji Z, Kiparaki M, Blanco J, Rimesso G, Flibotte S, Baker NE. Ribosomal Protein S12e Has a Distinct Function in Cell Competition. Dev Cell. 2018 Jan 8;44(1):42-55.e4. doi: 10.1016/j.devcel.2017.12.007. Epub 2018 Jan 8. PubMed PMID: 29316439; PubMed Central PMCID: PMC5784854.

Kale A, Rimesso G, Baker NE. Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals. PLoS One. 2016;11(12):e0167637. doi: 10.1371/journal.pone.0167637. eCollection 2016. PubMed PMID: 28030539; PubMed Central PMCID: PMC5193341.

Baker NE, Kale A. Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer. Mol Cell Oncol. 2016 Jan;3(1):e1029065. doi: 10.1080/23723556.2015.1029065. eCollection 2016 Jan. PubMed PMID: 27308545; PubMed Central PMCID: PMC4845181.

Kale A, Li W, Lee CH, Baker NE. Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica. Cell Death Differ. 2015 Aug;22(8):1300-12. doi: 10.1038/cdd.2014.218. Epub 2015 Jan 23. PubMed PMID: 25613379; PubMed Central PMCID: PMC4495355.

Ruggiero R, Kale A, Thomas B, Baker NE. Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons. PLoS Genet. 2012;8(11):e1003049. doi: 10.1371/journal.pgen.1003049. Epub 2012 Nov 29. PubMed PMID: 23209426; PubMed Central PMCID: PMC3510051.

Li W, Kale A, Baker NE. Oriented cell division as a response to cell death and cell competition. Curr Biol. 2009 Nov 17;19(21):1821-6. doi: 10.1016/j.cub.2009.09.023. Epub 2009 Oct 22. PubMed PMID: 19853449; PubMed Central PMCID: PMC2807641.

Fullard JF, Kale A, Baker NE. Clearance of apoptotic corpses. Apoptosis. 2009 Aug;14(8):1029-37. doi: 10.1007/s10495-009-0335-9. Review. PubMed PMID: 19291407.

Watve M, Thakar J, Kale A, Puntambekar S, Shaikh I, Vaze K, Jog M, Paranjape S. Bee-eaters ( Merops orientalis) respond to what a predator can see. Anim Cogn. 2002 Dec;5(4):253-9. doi: 10.1007/s10071-002-0155-6. Epub 2002 Nov 16. PubMed PMID: 12461603.
10 Protocols reviewed
Cleavable Affinity Purification (Cl-AP): A One-step Procedure to Affinity Purify Protein Complexes
Authors:  Ammarah Tariq, Lucy Green, Christian Soeller and James G. Wakefield, date: 11/20/2020, view: 3149, Q&A: 0

Cleavable Affinity Purification (Cl-AP) uses a tripartite system of Protein-A-Streptavidin beads and nanobodies, coupled with a biotinylated, thiol-cleavable linker, providing one-step affinity purification from lysates of tissues expressing tagged

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Fluorescence Measurement and Calibration of Intracellular pH in Starfish Oocytes
Authors:  Enako Hosoda and Kazuyoshi Chiba, date: 10/05/2020, view: 2959, Q&A: 0
Oocyte maturation is a process wherein an oocyte arrested at prophase of meiosis I resumes meiosis to become a fertilizable egg. In starfish ovaries, a hormone released from follicle cells activates the oocytes, resulting in an increase in their ...
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