Susanna Rosi Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol

Timothy Jopson Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol

Karen Krukowski Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol
Adler Dillman Nematology, UC Riverside, USA
13 protocols

Akira Karasawa Molecular Medicine, Cornell University, USA
2 protocols

Amey Redkar Department of Genetics, University of Cordoba
16 protocols

Beatriz Castro Purdue University
3 protocols

Editor
Xi Feng
  • Research scientist, University of California, San Francisco
Research focus
  • Neuroscience
  • Cognitive Neuroscience, Brain Tumor Mircroenvironment
  • 1 Author merit

Education

PhD, Chinese Academy of Sciences

Lab information

Rosi Lab at USCF

Publications

1. Feng, X., Liu, S., Chen, D., Rosi, S. and Gupta, N. (2018) Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model. eLife
2. *Krukowski, K., *Feng, X., Paladini, MS., Chou, A., Sacramento, K., Gure, K., Riparip, LK., Jones, T., Campbell-Beachler, M., Nelson, G. and Rosi, S. (2018) Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci. Rep. * co-first authors
3. Feng, X., Krukowski, K., Jopson, T. and Rosi S. (2017) Delayed-matching-to-place task in a dry maze to measure spatial working memory in mice. Bio Protoc.
4. Feng, X. and Rosi, S. (2017) Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation. Neural Regen Res.
5. Feng, X., Jopson, T., Paladini, M.S., Liu, S., West, B., Gupta, N. and Rosi, S. (2016) CSF-1R blockade prevents fractionated cranial irradiation induced memory loss. Journal of Neuroinflammation.
6. Feng, X., Szulzewsky, F., Yerevanian A., Chen Z., Heinzmann D., Rasmussen, D.R, Alvarez-Garcia, V., Kim, Y., Wang, B., Tamagno, I., Zhou, H., Li, X., Kettenmann, H., Ransohoff, R.M. and Hambardzumyan, D. (2015) Loss of CX3CR1 increases accumulation of inflammatory monocytes and promote gliomagenesis. Oncotarget.
7. Feng, X., Liu, X., Zhang, W., and Xiao, W. (2011) P53 Directly Suppresses BNIP3 Expression to Protect Against Hypoxia-induced Cell Death. EMBO Journal.
8. Krukowski, K., Chou, A., Feng, X., Tiret, B., Paladini, M.S., Riparip, L.K., Chaumeil, M.M., Lemere, C and Rosi, S. (2018) Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int. J. Mol. Sci.
9. Guglielmetti, C., Chou, A., Krukowski, K., Najac, C., Feng, X.,Riparip, L.R., Rosi, S., Chaumeil M.M., (2017) In vivo metabolic imaging of Traumatic Brain Injury. Scientific Reports.
10. Chen, Z., Feng, X., Herting, C.J., Alvares Garcia, V., Nie, K., Pong, W.W., Rasmussen, R., Dwivedi, B., Seby, S., Wolf, S.A., Gutmann, D., and Hambardzumyan, D. (2017) Identity and gene profile of tumor-associated macrophages in glioblastoma. Cancer Research
11. Szulzewsky, F., Pelz, A., Feng, X., Synowitz, M., Markovic, D., Langmann, T., Holtman, I.R., Wang, X., Eggen, B.J.L., Boddeke, H., Hambardzumyan, D., Wolf, S.A. and Ketternmann, H. (2015) Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and higly express GPNMB and SPP1. PLoS One.
12. Pitter, K.L.,Tamagno, I., Feng, X., Ghosal, K., Amankulor, N., Holland, E.C., and Hambardzumyan, D. (2014) The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions. Glia.
13. Hu, B., Zhang, W., Feng, X., Ji, W., Xie, X., and Xiao, W. (2014) Zebrafish eaf1 Suppresses Foxo3b Expression to Modulate Transcriptional Activity of Gata1 and Spi1 in Primitive Hematopoiesis. Developmental Biology.
14. Pong, W., Walker, J., Wylie, T., Magrini, V., Luo, J., Emnett, R., Choi, J., Cooper, M., Griffith, M.,Griffith, O., Rubin, J., Fuller, G., Piwnica-Worms, D., Feng, X., Hanbardzumyan, D., DiPersio, J., Mardis, J.,and Gutmann, D. (2013) F11R is a Novel Monocyte Prognostic Biomarker for Malignant Glioma. PLOS ONE.
15. Li, M., He, Y., Feng, X., and Huang, J. (2012) Genome-wide stidies of the transcriptional regulation by p53. Biochimica et Biophysica Acta.
16. Wan, X.,Hu, B., Liu, J.,Feng, X., and Xiao, W., (2011) The Essential Role of Mll in Zebrafish Hematopoiesis. Journal of Biological Chemistry.
17. Zhou, J., Feng, X., Ban, B., Liu, J., Wang, Z., and Xiao, W. (2009) The Elongation Factor Ell (Eleven-nineteen Lysine-Rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation. Journal of Biological Chemistry.
1 Protocol published
Delayed-matching-to-place Task in a Dry Maze to Measure Spatial Working Memory in Mice
Authors:  Xi Feng, Karen Krukowski, Timothy Jopson and Susanna Rosi, date: 07/05/2017, view: 4811, Q&A: 0
The delayed-matching-to-place (DMP) dry maze test is a variant of DMP water maze (Steele and Morris, 1999; Faizi et al., 2012) which measures spatial working/episodic-like learning and memory that depends on both hippocampal and cortical ...
10 Protocols reviewed
Assessing Prepulse Inhibition of Startle in Mice
Authors:  Christina Ioannidou, Giovanni Marsicano and Arnau Busquets-Garcia, date: 04/05/2018, view: 5440, Q&A: 0
Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia. Despite ...
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In vivo Leukemogenesis Model Using Retrovirus Transduction
Authors:  Hiroshi Okuda and Akihiko Yokoyama, date: 12/05/2017, view: 4058, Q&A: 0
Various genetic alterations such as chromosomal translocation cause leukemia. For examples, gene rearrangements of the mixed-lineage leukemia (MLL) gene generate MLL fusion genes, whose products are potent oncogenic drivers in ...
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23 Protocols edited
A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery
Authors:  Matthew J. Stopford, Scott P. Allen and Laura Ferraiuolo, date: 09/05/2019, view: 804, Q&A: 0
Amyotrophic lateral sclerosis (ALS) is an adult onset neurological disorder characterized by loss of motor neurons leading to progressive muscle wasting and eventually death. Astrocytes play a key role in disease pathogenesis. However, the ability ...
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Time-lapse Whole-field Fluorescence Imaging of Microglia Processes Motility in Acute Mouse Hippocampal Slices and Analysis
Microglia are the resident immune cells of the central nervous system (CNS). In the last year, the improvements in the transgenic mouse technologies and imaging techniques have shed light on microglia functions under physiological conditions. ...
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