Zheng Hou
  • Associate professor, Department of Pharmacology, Fourth Military Medical University, Xi'an, 2014-
Research focus
  • -
  • 1 Author merit


PhD, Fourth Military Medical University, Xi'an, China, 2009


• Wang, M., Fang, C., Ma, B., Luo, X. and Hou, Z. (2020). Regulation of cytokinesis: FtsZ and its accessory proteins. Curr Genet 66(1): 43-49.
• Ma, B., Fang, C., Lu, L., Wang, M., Xue, X., Zhou, Y., Li, M., Hu, Y., Luo, X. and Hou, Z. (2019). The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-beta-lactamase. Nat Commun 10(1): 3517
• Zhou, Y., Niu, C., Ma, B., Xue, X., Li, Z., Chen, Z., Li, F., Zhou, S., Luo, X. and Hou, Z. (2018). Inhibiting PSMalpha-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system. Cell Death Dis 9(3): 362.
• Li, Z., Zheng, Q., Xue, X., Shi, X., Zhou, Y., Da, F., Qu, D., Hou, Z. and Luo, X. (2016). Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC. Sci Rep 6: 37447.
• Ma, B., Niu, C., Zhou, Y., Xue, X., Meng, J., Luo, X. and Hou, Z. (2016). The Disulfide Bond of the Peptide Thanatin Is Dispensible for Its Antimicrobial Activity In Vivo and In Vitro. Antimicrob Agents Chemother 60(7): 4283-4289.
• Zhou, Y., Zhao, R., Ma, B., Gao, H., Xue, X., Qu, D., Li, M., Meng, J., Luo, X. and Hou, Z. (2016). Oligomerization of RNAIII-Inhibiting Peptide Inhibits Adherence and Biofilm Formation of Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo. Microb Drug Resist 22(3): 193-201.
• Hou, Z., Zhou, Y., Li, J., Zhang, X., Shi, X., Xue, X., Li, Z., Ma, B., Wang, Y., Li, M. and Luo, X. (2015). Selective in vivo and in vitro activities of 3,3'-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III. Sci Rep 5: 13637.
• Yin, S., Rao, G., Wang, J., Luo, L., He, G., Wang, C., Ma, C., Luo, X., Hou, Z. and Xu, G. (2015). Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus. PLoS One 10(11): e0143863.
• Ma, B., Zhou, Y., Li, M., Yu, Q., Xue, X., Li, Z., Da, F., Hou, Z. and Luo, X. (2015). RIP-V improves murine survival in a sepsis model by down-regulating RNAIII expression and alpha-hemolysin release of methicillin-resistant Staphylococcus aureus. Pharmazie 70(2): 81-87.
• Li, M., Li, J., Zhou, Y., Xue, X.-Y., Shi, X., Tu, Z.-y., Hou, Z. and Luo, X.-X. (2013). Synthesis, photoluminescent behaviors, and antibacterial activities of 3-acetylcoumarins. Res Chem Intermed 41(5):3289-3296.
• Li, J., Hou, Z., Chen, G. H., Li, F., Zhou, Y., Xue, X. Y., Li, Z. P., Jia, M., Zhang, Z. D., Li, M. K. and Luo, X. X. (2014). Synthesis, antibacterial activities, and theoretical studies of dicoumarols. Org Biomol Chem 12(29): 5528-5535.
• Lu, L., Hou, Z., Li, L., Yang, Y., Wang, X., Zhang, B., Ren, M., Zhao, D., Miao, Z., Yu, L. and Yao, Y. (2014). Methylation pattern of H19 exon 1 is closely related to preeclampsia and trophoblast abnormalities. Int J Mol Med 34(3): 765-771.
• Li, J., Hou, Z., Li, F., Zhang, Z., Zhou, Y., Luo, X.-X. and Li, M. (2014). Synthesis, photoluminescent, antibacterial activities and theoretical studies of 4-hydroxycoumarin derivatives. J Mol Stuct 1075: 509-514.
• Hou, Z., Da, F., Liu, B., Xue, X.-Y., Xu, X., Zhou, Y., Li, M., Li, Z., Ma, X., Meng, J., Jia, M., Wang, Y. and Luo, X.-X. (2013). R-thanatin inhibits the growth and biofilm formation of methicillin-resistant Staphylococcus epidermidis in vivo and in vitro. Antimicrob Agents Chemothe 57.
• Zhou, Y., Hou, Z., Fang, C., Xue, X., Da, F., Wang, Y., Bai, H. and Luo, X. (2013). Comparison of microplate and macrodilution methods in time-kill study of new antimicrobial drugs. Folia Microbiol (Praha) 58(1): 9-16.
• Li, M. K., Li, J., Liu, B. H., Zhou, Y., Li, X., Xue, X. Y., Hou, Z. and Luo, X. X. (2013). Synthesis, crystal structures, and anti-drug-resistant Staphylococcus aureus activities of novel 4-hydroxycoumarin derivatives. Eur J Pharmacol 721(1-3): 151-157.
• Hou, Z., Lu, J., Fang, C., Zhou, Y., Bai, H., Zhang, X., Xue, X., Chen, Y. and Luo, X. (2011). Underlying mechanism of in vivo and in vitro activity of C-terminal-amidated thanatin against clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli. J Infect Dis 203(2): 273-282.
• Hou, Z., Zhou, Y., Wang, H., Bai, H., Meng, J., Xue, X.-Y. and Luo, X.-X. (2011). Co-blockade of mecR1/blaR1 signal pathway to restore antibiotic susceptibility in clinical isolates of methicillin-resistant Staphylococcus aureus. Archives of medical science : AMS 7: 414-422.
• Hou, Z., Meng, J. Niu, C., Wang, H., Liu, J., Hu, B., Jia, M. and Luo, X. (2007). Restoration of antibiotic susceptibility in methicillin-resistant Staphylococcus aureus by targeting mecR1 with a phosphorothioate deoxyribozyme. Clin Exp Pharmacol Physiol 34: 1160-1164.
• Hou, Z., Meng, J. Zhao, J., Hu, B., Liu, J., Yan, X., Jia, M., and Luo, X. (2007).. Inhibition of β-lactamase-mediated oxacillin resistance in Staphylococcus aureus by a deoxyribozyme. Acta Pharmacol Sin 2007; 28: 1775-1782.
1 Protocol published
Contemporaneous Measurement of Outer and Inner Membrane Permeability in Gram-negative Bacteria
Authors:  Bo Ma, Chao Fang, Jing Zhang, Mingzhi Wang, Xiaoxing Luo and Zheng Hou, date: 03/05/2020, view: 656, Q&A: 0
The emergence and rapid spread of multidrug resistance in bacteria have led to the urgent need for novel antibacterial agents. Membrane permeabilization is the mechanism for many antibacterial molecules that are being developed against gram-negative ...
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