Alessandro Didonna University of California, San Francisco
47 protocols

Ivan Zanoni Harvard Medical School
78 protocols

Nicole Salazar San Francisco State University
2 protocols

Olga Kopach Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, UK
2 protocols

Dana Manuela Savulescu
  • Research scientist, National Institute for Communicable Diseases
Research focus
  • Immunology
  • Reproductive immunology; Immune tolerance; Cell biology; Human pregnancy; Molecular biology


PhD, Technion - Israel Institute of Technology, 2013

Lab information

Dr. Melinda Suchard's lab; Centre for Vaccines and Immunology



• W Howard, D Savulescu, L Berrie, AJ Puren. Description of non-polio enteroviruses identified in two national surveillance programmes in South Africa. Southern African Journal of Infectious Diseases 2021: Vol 35, No 1, a196.
• M Suchard, C Adu-Gyamfi, BM Cumming, D. Savulescu. Evolutionary views of Tuberculosis: indoleamine 2,3-dioxygenase catalysed nicotinamide synthesis reflects shifts in macrophage metabolism. BioEssays 2020: 42, 1900220.
• D Savulescu, V Duxbury, K Scheuemaier, S Malfeld, A Koen, S Jones, M Groome, S Madhi, C Cutland, M Suchard. The prevalence of HLA antibodies during pregnancy and in new-born babies. American Journal of Reproductive Immunology 2020: 84:e13264.
• CG Adu-Gyamfi, T Snyman, L Makhathini, F Darboe, A Penn-Nicholson, M Fisher, D Savulescu, CJ Hoffman, RE Chaisson, NA Martinsson, TJ Scriba, JA George, MS Suchard. Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme immunosorbent assay, for pulmonary Tuberculosis. International Journal of Infectious Diseases 2020: 99:441-8.
• CG Adu-Gyamfi, D Savulescu, JA George, M Suchard. Indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan catabolism: leading star or supporting act in TB and HIV pas-de-deux? Frontiers in Cellular and Infection Microbiology. 2019: 9:372.
• R Nagler, D Savulescu, M Gavish. Cigarette Smoke-induced reduction in binding of the salivary translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4. Summary featured on World Biomedical Frontiers ISSN: 2328-0116, Cancer Issue (
• R Nagler, D Savulescu, M Gavish. Cigarette Smoke-induced reduction in binding of the salivary Translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4.
• E Shahar, U Attias, D Savulescu, J Genizin, M Gavish, R Nagler. Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis. Epilepsy Research. 2014:108(1):117-24.
• D Savulescu, J Feng, YS Ping, O Mai, U Boehm, B He, B. O’Malley, P Melamed. Goandotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Molecular Endocrinology. 2013:27(11):1856-70.
• P Melamed, D Savulescu, S Lim, A Wijeweera, L Zhuojuan, L Min, L Pnueli. Gonadotropin releasing hormone (GnRH)-signaling downstream of calmodulin. Journal of Neuroendocrinology. 2012:24(12):1463-75.
• Y Ullmann, Y Klein, D Savulescu, I Borovoi, D Egozi, M Gavish, R Nagler. Salivary monitoring related to major surgery. European Journal of Clinical Investigation. 2010:40(12):1074-80.
• R Nagler, S Cohen, D Savulescu, S Leschiner, I Otradnov, M Gavish. Penicilamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer. Oncology. 2010:78(1):12-9.
• R Kremer, LA Best, D Savulescu, M Gavish, RM Nagler. Pleural fluid analysis of lung cancer vs. benign inflammatory disease patients. British Journal of Cancer. 2010:102(7):1180-4.
• R Nagler, O Ben-Izhak, D Savulescu, E Krayzler, S Akrish, S Leschiner, I Otradnov, S Zeno, L Veenman, M Gavish. Oral cancer, cigarette smoke and mitochondrial 18 kDa translocator protein (TSPO) – in vitro, in vivo, salivary analysis. Biochimica et Biophysica Acta – Molecular Basis of Disease. 2010:1802(5):545-61.
• R Brik, I Rosen, D Savulescu, I Borovoi, M Gavish, R Nagler. Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis. Molecular Medicine. 2010:16(3-4):122-8.
• R Nagler*, D Savulescu*, E Krayzler, S Leschiner, L Veenman, M Gavish (*equal contribution). Cigarette smoke decreases salivary 18 kDa translocator protein binding affinity – in association with oxidative stress. Current Medicinal Chemistry. 2010: 17(23):2539-46.
• T Shpitzer, Y Hamzany, G Bahar, R Feinmesser, D Savulescu, I Borovoi, M Gavish, RM Nagler. Salivary analysis of oral cancer biomarkers. British Journal of Cancer. 2009:101(7):1194-8.
4 Protocols reviewed
Fluorescence-based Single-cell Analysis of Whole-mount-stained and Cleared Microtissues and Organoids for High Throughput Screening
Authors:  Henrik Renner, Mandy Otto, Martha Grabos, Hans R. Schöler and Jan M. Bruder, date: 06/20/2021, view: 63, Q&A: 0

Three-dimensional (3D) cell culture, especially in the form of organ-like microtissues (“organoids”), has emerged as a novel tool potentially mimicking human tissue biology more closely than standard two-dimensional culture. Typically,

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A Quantitative Single-cell Flow Cytometry Assay for Retrograde Membrane Trafficking Using Engineered Cholera Toxin
Authors:  Mariska S. Simpson, Wayne I. Lencer and Phi Luong, date: 08/05/2020, view: 1741, Q&A: 0
The organization and distribution of proteins, lipids, and nucleic acids in eukaryotic cells is an essential process for cell function. Retrograde trafficking from the plasma membrane to the Golgi and endoplasmic reticulum can greatly modify cell ...
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