Alessandro Didonna University of California, San Francisco
35 protocols

Ivan Zanoni Harvard Medical School
78 protocols

Nicole Salazar San Francisco State University
2 protocols

Talita Melo Hanchuk University of Campinas
2 protocols

Dana Manuela Savulescu
  • Research scientist, National Institute for Communicable Diseases
Research focus
  • Immunology
  • Reproductive immunology; Immune tolerance; Cell biology; Human pregnancy; Molecular biology


PhD, Technion - Israel Institute of Technology, 2013

Lab information

Dr. Melinda Suchard's lab; Centre for Vaccines and Immunology



M Suchard, C Adu-Gyamfi, BM Cumming, D. Savulescu. Evolutionary views of Tuberculosis: indoleamine 2,3-dioxygenase catalysed nicotinamide synthesis reflects shifts in macrophage metabolism. Apr 17, 2020. BioEssays 2020: 42, 1900220.
• CG Adu-Gyamfi, D Savulescu, JA George, M Suchard. Indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan catabolism: leading star or supporting act in TB and HIV pas-de-deux? Oct 29, 2019. Frontiers in Cellular and Infection Microbiology. 2019.
• R. Nagler, D. Savulescu, M. Gavish. Cigarette Smoke-induced reduction in binding of the salivary translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4. Summary featured on World Biomedical Frontiers ISSN: 2328-0116, June 2016 Cancer Issue (
• R. Nagler, D. Savulescu, M. Gavish. Cigarette Smoke-induced reduction in binding of the salivary Translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4.
• E. Shahar, U. Attias, D. Savulescu, J. Genizin, M. Gavish, R. Nagler. Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis. Epilepsy Research. 2014:108(1):117-24.
• D. Savulescu, J. Feng, Y.S. Ping, O. Mai, U. Boehm, B. He, B.W. O’Malley, P. Melamed. Goandotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Molecular Endocrinology. 2013:27(11):1856-70.
• P. Melamed, D. Savulescu, S. Lim, A. Wijeweera, L. Zhuojuan, L. Min, L. Pnueli. Gonadotropin releasing hormone (GnRH)-signaling downstream of calmodulin. Journal of Neuroendocrinology. 2012:24(12):1463-75.
• Y. Ullmann, Y. Klein, D. Savulescu, I. Borovoi, D. Egozi, M. Gavish, R. Nagler. Salivary monitoring related to major surgery. European Journal of Clinical Investigation. 2010:40(12):1074-80.
• R. Nagler, S. Cohen, D. Savulescu, S. Leschiner, I. Otradnov, M. Gavish. Penicilamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer. Oncology. 2010:78(1):12-9.
• R. Kremer, L.A. Best, D. Savulescu, M. Gavish, R.M. Nagler. Pleural fluid analysis of lung cancer vs. benign inflammatory disease patients. British Journal of Cancer. 2010:102(7):1180-4.
• R. Nagler, O. Ben-Izhak, D. Savulescu, E. Krayzler, S. Akrish, S. Leschiner, I. Otradnov, S. Zeno, L. Veenman, M. Gavish. Oral cancer, cigarette smoke and mitochondrial 18 kDa translocator protein (TSPO) – in vitro, in vivo, salivary analysis. Biochimica et Biophysica Acta – Molecular Basis of Disease. 2010:1802(5):545-61.
• R. Brik, I. Rosen, D. Savulescu, I. Borovoi, M. Gavish, R. Nagler. Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis. Molecular Medicine. 2010:16(3-4):122-8).
• R. Nagler*, D. Savulescu*, E. Krayzler, S. Leschiner, L. Veenman, M. Gavish (*equal contribution). Cigarette smoke decreases salivary 18 kDa translocator protein binding affinity – in association with oxidative stress. Current Medicinal Chemistry. 2010: 17(23):2539-46.
• T. Shpitzer, Y. Hamzany, G. Bahar, R. Feinmesser, D. Savulescu, I. Borovoi. M. Gavish, R.M. Nagler. Salivary analysis of oral cancer biomarkers. British Journal of cancer. 2009:101(7):1194-8.
3 Protocols reviewed
A Quantitative Single-cell Flow Cytometry Assay for Retrograde Membrane Trafficking Using Engineered Cholera Toxin
Authors:  Mariska Simpson, Wayne I. Lencer and Phi Luong, date: 08/05/2020, view: 693, Q&A: 0
The organization and distribution of proteins, lipids, and nucleic acids in eukaryotic cells is an essential process for cell function. Retrograde trafficking from the plasma membrane to the Golgi and endoplasmic reticulum can greatly modify cell ...
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Isolation and High Throughput Flow Cytometric Apoptosis Assay of Human Neutrophils to Enable Compound Library Screening
Authors:  K. D. Herman, A. Rahman and L. R. Prince, date: 06/05/2020, view: 887, Q&A: 0
The study of human neutrophils in vitro is challenging due to their short half-life and propensity for activation. However, with careful handling and manipulation in the laboratory, they can be a powerful tool to investigate immune ...
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