Ivan Zanoni Harvard Medical School
78 protocols

Nicole Salazar San Francisco State University
2 protocols

Talita Melo Hanchuk University of Campinas
2 protocols

Yang Fu Harvard Medical School
11 protocols

Dana Manuela Savulescu
  • Research scientist, National Institute for Communicable Diseases
Research focus
  • Immunology
  • Reproductive immunology; Immune tolerance; Cell biology; Human pregnancy; Molecular biology


PhD, Technion - Israel Institute of Technology, 2013

Lab information

Dr. Melinda Suchard's lab; Centre for Vaccines and Immunology



M Suchard, C Adu-Gyamfi, BM Cumming, D. Savulescu. Evolutionary views of Tuberculosis: indoleamine 2,3-dioxygenase catalysed nicotinamide synthesis reflects shifts in macrophage metabolism. Apr 17, 2020. BioEssays 2020: 42, 1900220.
• CG Adu-Gyamfi, D Savulescu, JA George, M Suchard. Indoleamine 2,3-dioxygenase (IDO)-mediated tryptophan catabolism: leading star or supporting act in TB and HIV pas-de-deux? Oct 29, 2019. Frontiers in Cellular and Infection Microbiology. 2019. https://doi.org/10.338.
• R. Nagler, D. Savulescu, M. Gavish. Cigarette Smoke-induced reduction in binding of the salivary translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4. Summary featured on World Biomedical Frontiers ISSN: 2328-0116, June 2016 Cancer Issue (http://biomedfrontiers.org/category/cancer/).
• R. Nagler, D. Savulescu, M. Gavish. Cigarette Smoke-induced reduction in binding of the salivary Translocator protein is not mediated by free radicals. Biochimie. 2016:121:1-4.
• E. Shahar, U. Attias, D. Savulescu, J. Genizin, M. Gavish, R. Nagler. Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis. Epilepsy Research. 2014:108(1):117-24.
• D. Savulescu, J. Feng, Y.S. Ping, O. Mai, U. Boehm, B. He, B.W. O’Malley, P. Melamed. Goandotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Molecular Endocrinology. 2013:27(11):1856-70.
• P. Melamed, D. Savulescu, S. Lim, A. Wijeweera, L. Zhuojuan, L. Min, L. Pnueli. Gonadotropin releasing hormone (GnRH)-signaling downstream of calmodulin. Journal of Neuroendocrinology. 2012:24(12):1463-75.
• Y. Ullmann, Y. Klein, D. Savulescu, I. Borovoi, D. Egozi, M. Gavish, R. Nagler. Salivary monitoring related to major surgery. European Journal of Clinical Investigation. 2010:40(12):1074-80.
• R. Nagler, S. Cohen, D. Savulescu, S. Leschiner, I. Otradnov, M. Gavish. Penicilamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer. Oncology. 2010:78(1):12-9.
• R. Kremer, L.A. Best, D. Savulescu, M. Gavish, R.M. Nagler. Pleural fluid analysis of lung cancer vs. benign inflammatory disease patients. British Journal of Cancer. 2010:102(7):1180-4.
• R. Nagler, O. Ben-Izhak, D. Savulescu, E. Krayzler, S. Akrish, S. Leschiner, I. Otradnov, S. Zeno, L. Veenman, M. Gavish. Oral cancer, cigarette smoke and mitochondrial 18 kDa translocator protein (TSPO) – in vitro, in vivo, salivary analysis. Biochimica et Biophysica Acta – Molecular Basis of Disease. 2010:1802(5):545-61.
• R. Brik, I. Rosen, D. Savulescu, I. Borovoi, M. Gavish, R. Nagler. Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis. Molecular Medicine. 2010:16(3-4):122-8).
• R. Nagler*, D. Savulescu*, E. Krayzler, S. Leschiner, L. Veenman, M. Gavish (*equal contribution). Cigarette smoke decreases salivary 18 kDa translocator protein binding affinity – in association with oxidative stress. Current Medicinal Chemistry. 2010: 17(23):2539-46.
• T. Shpitzer, Y. Hamzany, G. Bahar, R. Feinmesser, D. Savulescu, I. Borovoi. M. Gavish, R.M. Nagler. Salivary analysis of oral cancer biomarkers. British Journal of cancer. 2009:101(7):1194-8.
2 Protocols reviewed
Isolation and High Throughput Flow Cytometric Apoptosis Assay of Human Neutrophils to Enable Compound Library Screening
Authors:  K. D. Herman, A. Rahman and L. R. Prince, date: 06/05/2020, view: 548, Q&A: 0
The study of human neutrophils in vitro is challenging due to their short half-life and propensity for activation. However, with careful handling and manipulation in the laboratory, they can be a powerful tool to investigate immune ...
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DNA Immunization Using in vivo Electroporation for Generating Monoclonal Antibodies Against Mouse IL-9R
Membrane proteins such as cytokine receptors and G protein-coupled receptors can be drug targets. Recently, we have generated specific monoclonal antibodies (mAbs) against the mouse IL-9 receptor (IL-9R) and found that IL-9R on memory B cells have ...
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