Andreas Fischer Vascular Signaling and Cancer German Cancer Research Center
2 protocols

Lena Wiedmann Vascular Signaling and Cancer German Cancer Research Center (DKFZ)
1 protocol

Max Hubert Vascular Signaling and Cancer German Cancer Research Center
1 protocol

Juan Rodríguez Vita
  • Group leader, CIPF
Research focus
  • 1 Author merit


Ph.D. In Life Sciences (Discipline: Molecular Medicine), Universidad Autónoma de Madrid, 2007

Lab information


Publications (since 2005)

1. Alsina-Sanchis E, Mulfarth R, Moll I, Mogler C, Rodriguez-Vita J*, Fischer A*. Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 2020 Nov 2:molcanres.0650.2020. doi: 10.1158/1541-7786.MCR-20-0650.

2. Klose R., Prinz A., Tetzlaff F., Weis E., Moll I., Rodriguez-Vita J., Oka C., Korff T., Fischer A. Loss of the Serine Protease HTRA1 Impairs Smooth Muscle Cells Maturation. Sci Rep, 9 (1), 18224 2019.

3. Goossens P*, Rodriguez-Vita J*, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL, Lawrence T. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metab. 2019 Mar 21. pii: S1550-4131(19)30128-7. *Co-first authors. (Research article)

4. Ribera J*, Rodríguez-Vita J*, Cordoba B, Portolés I, Casals G, Casals E, Jiménez W, Puntes V, Morales-Ruiz M. Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats. PLoS One. 2019 Jun 24;14(6):e0218716. *Co-first authors. (Research article)

5. Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A. MPDZ promotes DLL4-induced Notch signaling during angiogenesis. Elife. 2018 Apr 5;7. pii: e32860. (Research article)

6. Rodriguez-Vita J, Tetzlaff F, Fischer A. Notch controls endothelial cells. Oncoscience. 2017 Jun 25;4(5-6):45-46. (Comment)

7. Rodriguez-Vita J, Fischer A. Notch Signaling facilitase crossing of endothelial barriers by tumor cells. Mol Cell Oncol. 2017 Apr 3;4(3):e1311828. (Comment)

8. Rodriguez-Vita J, Fischer A. Notch1 induces endothelial senescence and promotes tumor progression. Cell Cycle. 2017 May 19;16(10):911-912. (Comment)

9. Wieland E*, Rodriguez-Vita J*, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. 2017 Mar 13;31(3):355-367. *Co-first authors. (Research article)

10. Morales-Ruiz M., Rodriguez-Vita J., Ribera J., Jimenez W. Pathophysiology of Portal Hypertension. Jan 2015. PanVascular Medicine. ISBN: 978-3-642-37077-9 (Print) 978-3-642-37078-6 (On-line) Pages 3631-3665 (Book chapter)

11. Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12865-70. (Research article)

12. Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodríguez-Vita J, Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jiménez W, Morales-Ruiz M. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. Liver Int. 2014 Feb 19. (Research article)

13. Rodriguez-Vita J, Morales-Ruiz M. Down the liver sinusoidal endothelial cell (LSEC) hole. Is there a role for lipid rafts in LSEC fenestration? Hepatology. 2013 Mar;57(3):1272-4. (Comment)

14. Rodrigues Díez R, Rodrigues-Díez R, Lavoz C, Rayego-Mateos S, Civantos E, Rodríguez-Vita J, Mezzano S, Ortiz A, Egido J, Ruiz-Ortega M. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. PLoS One. 2010 Nov 30;5(11):e14145. (Research article)

15. Rodriguez-Vita J, Lawrence T. The resolution of inflammation and cancer. Cytokine Growth Factor Rev. 2010 Feb;21(1):61-5. (Review article)

16. Sánchez-López E, Rayego S, Rodrigues-Díez R, Rodriguez JS, Rodrigues-Díez R, Rodríguez-Vita J, Carvajal G, Aroeira LS, Selgas R, Mezzano SA, Ortiz A, Egido J, Ruiz-Ortega M. CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. J Am Soc Nephrol. 2009 Jul;20(7):1513-26. (Research article)

17. Rodríguez-Vita J, Sánchez-Galán E, Santamaría B, Sánchez-López E, Rodrigues-Díez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M. Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation. PLoS One. 2008;3(12):e3959. (Research article)

18. Rodrigues-Díez R, Carvajal-González G, Sánchez-López E, Rodríguez-Vita J, Rodrigues Díez R, Selgas R, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M. Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. Pharm Res. 2008 Oct;25(10):2447-61. (Research article)

19. Carvajal G, Rodríguez-Vita J, Rodrigues-Díez R, Sánchez-López E, Rupérez M, Cartier C, Esteban V, Ortiz A, Egido J, Mezzano SA, Ruiz-Ortega M. Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. Kidney Int. 2008 Sep;74(5):585-95. (Research article)

20. Sanchez-Lopez E, Rodriguez-Vita J, Cartier C, Ruperez M, Esteban V, Carvajal G, Rodrigues-Diez R, Plaza JJ, Egido J, Ruiz-Ortega M. Inhibitory effect of interleukin-1- on Angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Jan;294(1):F149-60. (Research article)

21. Rupérez M, Rodrigues-Díez R, Blanco-Colio LM, Sánchez-López E, Rodríguez-Vita J, Esteban V, Carvajal G, Plaza JJ, Egido J, Ruiz-Ortega M. HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways. Hypertension. 2007 Aug;50(2):377-83. (Research article)

22. Marta Ruiz-Ortega, Juan Rodríguez-Vita, Elsa Sanchez-Lopez, Gisselle Carvajal and Jesús Egido. TGF β signaling in vascular fibrosis. Cardiovasc Res. 2007 May 1;74(2):196-206. (Review article)

23. Ruiz-Ortega M, Esteban V, Ruperez M, Sanchez-Lopez E, Rodriguez-Vita J, Carvajal G, Egido J. Renal and vascular hypertension-induced inflammation: role of angiotensin II. Curr Opin Nephrol Hypertens. 2006 Mar;15(2):159-66. (Review article)

24. M. Ruiz-Ortega, M Ruperez, V Esteban, J Rodriguez-Vita, E Sanchez-Lopez, G Carvajal, J Egido. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transplant. 2006 Nov 9 Jan;21(1):16-20. (Review article)

25. Rodriguez-Vita J, Ruiz-Ortega M, Rupérez M, Esteban V, Sanchez-López E, Plaza JJ, Egido J. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res. 2005 Jul 22;97(2):125-34. (Research article)

26. Rodríguez-Vita J, Sánchez-López E, Esteban V, Rupérez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005;111:2509-2517. (Research article)

27. V. Esteban, M. Ruperez BsC, E. Sánchez-López, J. Rodríguez-vita, O. Lorenzo, H Demaegdt, P. Vanderheyden, J. Egido, M. Ruiz-Ortega. Angiotensin IV activates the nuclear transcription factor-kappa B (NF-κB) and related genes in vascular smooth muscle cells. Circ Res.2005 May;13:965-973. (Research article)
1 Protocol published
Isolation of Murine Primary Aortic Smooth Muscle Cells
Authors:  Max Ole Hubert, Juan Rodriguez-Vita, Lena Wiedmann and Andreas Fischer, date: 02/05/2021, view: 2804, Q&A: 1

Vascular smooth muscle cells (VSMCs) have been cultured for decades to study the role of these cells in cardiovascular disorders. The most common source of VSMCs is the rat aorta. Here we show the adaptation of this method to isolate and culture

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