Po-Lin Chiu
  • Faculty, Arizona State University
Research focus
  • Biophysics
  • Cryo-EM of membrane protein and lipid-protein interaction


Ph.D., University of California, Davis, 2009

Lab information

Po-Lin Chiu Lab


Aryal, R.P.*, Kwak, P.B.*, Tamayo, A.G., Chiu, P.-L., Walz, T., and Weitz, C.J. 2017. Macromolecular assemblies of the mammalian circadian clock. Mol Cell 67:770-782. (*equal contributions)
Kalbermatter, D.*, Chiu, P.-L.*, Jeckelmann, J.-M., Ucurum, Z., Walz, T., and Fotiadis, D. 2017. Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change. J Struct Biol 199:39-45. (*equal contributions)
Leksa, N.C., Chiu, P.-L., Bou-Assaf, G.M., Quan, C., Liu, Z., Goodman, A.B., Chambers, M.G., Tsutakawa, S.E., Hammel, M., Peters, R.T., Walz, T., and Kulman, J.D. 2017. The structural basis for the functional comparability of factor VIII and the long-acting variant rFVIIIFc. J Thromb Haemost 15:1167-1179.
Klara, S.S., Saboe, P.O., Sines, I.T., Babaei, M., Chiu, P.-L., DeZorzi, R., Dayal, K., Walz, T., Kumar, M., and Mauter, M.S. 2016. Magnetically directed two-dimensional crystallization of OmpF membrane proteins in block copolymers. J Am Chem Soc 138:28-31.
Chiu, P.-L.*, Li, X.*, Li, Z., Beckett, B., Brilot, A.F., Grigorieff, N., Agard, D.A., Cheng, Y., and Walz, T. 2015. Evaluation of super-resolution performance of the K2 electron counting camera using 2D crystals of aquaporin-0. J Struct Biol 192:163-173. (*equal contributions)
Kalbermatter, D., Jeckelmann, J.-M., Chiu, P.-L., Ucurum, Z., Walz, T., and Fotiadis, D. 2015. 2D and 3D crystallization of the wild-type IIC domain of the glucose PTS transporter from Escherichia coli. J Struct Biol 191:376-380.
Chiu, P.-L.*, Bou-Assaf, G.*, Chhabra, E.S., Chambers, M.G., Liu, L., Peters, R., Kulman, J.D., and Walz, T. 2015. Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry. Blood 126:935-938. (*equal contributions)
Commentary in Blood: Krishnaswamy, S. 2015. FVIII-VWF dos-à-dos. Blood 126:923-924.
Hite, R.K.*, Chiu, P.-L.*, Schuller, J., and Walz, T. 2015. Effect of lipid head groups on double-layered two-dimensional crystals formed by aquaporin-0. PLoS ONE 10:e0117371. (*equal contributions)
Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P.-L., Rangl, M., Scheuring, S., Nimigean, C.M., and Stahlberg, H. 2014. Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nat Commun 5:3106-3115.
Hopkins, L.E., Patchin, E.S., Chiu, P.-L., Brandenberger, C., Smiley-Jewell, S., and Pinkerton, K.E. 2014. Nose-to-brain transport of aerosolized quantum dots following acute exposure. Nanotoxicol 8:885-893.
Evans, J.E., Jungjohann, K.L., Wong, P.C.K., Chiu, P.-L., Dutrow, G.H., Arslan, I., and Browning, N.D. 2013. Visualizing macromolecular complexes with in situ liquid scanning transmission electron microscopy. Micron 43:1085-1090.
Chiu, P.-L., Kelly, D.F., and Walz, T. 2011. The use of trehalose in the preparation of specimens for electron microscopy. Micron 42:762-772.
Paoli, E.-E., Kruse, D.E., Seo, J.W., Zhang, H., Kheirolomoom, A., Watson, K.D., Chiu, P.-L., Stahlberg, H., and Ferrara, K.W. 2010. An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: importance of formulation. J Control Release 143:13-22.
Chiu, P.-L., Pagel, M.D., Evans, J.E., Chou, H.-T., Zeng, X., Gipson, B., Stahlberg, H., and Nimigean, C.M. 2007. The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 Å resolution. Structure 15:1053-1064.
Feature in Structure: Taraska, J.W. and Zagotta, W. 2007. Cyclic nucleotide-regulated ion channel: Spotlight on symmetry. Structure 15:1023-1024.
Renault, L., Chou, H.-T., Chiu, P.-L., Hill, R.M., Zeng, X., Gipson, B., Zhang, Z.Y., Cheng, A., Unger, V., and Stahlberg, H. 2006. Milestones in electron crystallography. J Comput Aided Mol Des 20:519-527.
Chiu, P.-L., Wu, C.-Y., Taso, J.-H., and Chang, F.-H. 2001. Drug delivery through liposome by ultrasonic cavitation. Biomed Eng-App, Basis, & Comm 13:47-52.