Shaarika Sarasija
  • Post-Doc, McGill University
Research focus
  • Cell biology
  • C. elegans, Presenilin, Calcium, Mitochondria, Neurodegeneration, Alzheimer's Disease, Aging


PhD, Albany Medical College, 2017

1. Sarasija S, Norman KR. Measurement of oxygen consumption rates in intact Caenorhabditis elegans. J. Vis. Exp. 2019 (144), e59277

2. Sarasija S, Norman KR. Role of presenilin in mitochondrial oxidative stress and neurodegeneration in Caenorhabditis elegans. Antioxidants 2018 7(9), 111

3. Sarasija S, Norman KR. Mutations in presenilin cause defects in mitochondrial calcium homeostasis and metabolic activity resulting in neurodegeneration. eLIFE 2018 7: e33052.
Research Highlight: Clark N. Alternative model for alternative hypothesis. Lab Animal 2018 47(231)

4. Sarasija S, Norman KR. H2DCFDA fluorescence measurement of ROS in Caenorhabditis elegans. Bio-Protocol 2018 8(7)

5. Sarasija S, Norman KR. Mitochondrial morphology analysis in in Caenorhabditis elegans. Bio-Protocol 2018 8(7)

6. Sarasija S, Norman KR. A γ-secretase independent role for presenilin in calcium homeostasis impacts mitochondrial function and morphology in Caenorhabditis elegans. Genetics. 2015; 201(4):1453-66.
2 Protocols reviewed
Optical Stimulation and Electrophysiological Analysis of Regenerating Peripheral Axons
Authors:  Patricia J. Ward and Arthur W. English, date: 06/20/2019, view: 135, Q&A: 0
Although axons in the peripheral nervous system can regenerate, functional recovery after nerve injuries is poor. Activity-based therapies, such as exercise and electrical stimulation, enhance the regeneration of cut peripheral axons. Despite their ...
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Optical Clearing and Index Matching of Tissue Samples for High-resolution Fluorescence Imaging Using SeeDB2
Authors:  Meng-Tsen Ke and Takeshi Imai, date: 10/20/2018, view: 2630, Q&A: 1
Tissue clearing techniques are useful for large-scale three-dimensional fluorescence imaging of thick tissues. However, high-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical ...
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