Mary Morada Haskins Laboratories, Pace University, USA, USA,
1 protocol

Nigel Yarlett
  • Chemistry and Physical Sciences, and Haskins Laboratories, Pace University, USA, USA,
Research focus
  • Microbiology
  • 1 Author merit


PhD, Cardiff University, UK, 1982

Current position

Distinguished Professor, Haskins Laboratories, Pace University, USA


  1. Bartulos, R. C., Rogers, M., Williams, T., Brinkmann, H., Cerff, R., Liaud, M. F., Hehl, A., Yarlett, N., Gruber, A., Kroth, P. and Giezen, M. (2018) Mitochondrial targeting of glycolysis in a major lineage of eukaryotes. Gen Biol Evol (in press).
  2. Morada, M., Lee, S., Gunther-Cummins, L., Weiss, L. M., Widmer, G., Tzipori, S. and Yarlett, N. (2016). Continuous culture of Cryptosporidium parvum using hollow fiber technology. Int J Parasitol 46(1): 21-29.
  3. Wring, S., Gaukel, E., Nare, B., Jacobs, R., Beaudet, B., Bowling, T., Mercer, L., Bacchi, C., Yarlett, N., Randolph, R., Parham, R., Rewerts, C., Platner, J. and Don, R. (2014). Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis. Parasitology 141(1): 104-118.
  4. Morada, M., Pendyala, L., Wu, G., Merali, S. and Yarlett, N. (2013). Cryptosporidium parvum induces an endoplasmic stress response in the intestinal adenocarcinoma HCT-8 cell line. J Biol Chem 288(42): 30356-30364.
  5. Yarlett, N. and Morada, M. (2012) Antiparasitic Drug Discovery for the Polyamine Pathway. In: Polyamine Drug Discovery. Patrick Woster & Robert Casero Jr. (eds). SC Drug Discovery Series No. 17. Royal Society of Chemistry pub.
  6. Jacobs, R. T., Plattner, J. J., Nare, B., Wring, S. A., Chen, D., Freund, Y., Gaukel, E. G., Orr, M. D., Perales, J. B., Jenks, M., Noe, R. A., Sligar, J. M., Zhang, Y. K., Bacchi, C. J., Yarlett, N. and Don, R. (2011). Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis. Future Med Chem 3(10): 1259-1278.
  7. Mercer, L., Bowling, T., Perales, J., Freeman, J., Nguyen, T., Bacchi, C., Yarlett, N., Don, R., Jacobs, R. and Nare, B. (2011). 2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. PLoS Negl Trop Dis 5(2): e956.
  8. Perales, J.B., Freeman, J., Bacchi, C. J., Bowling, T., Don, R., Gaukel, E., Mercer, L., Moore III, J.A., Nare, B., Nguyen, T. M., Noe, R. A., Randolph, R., Rewarts, C., Wring, S., Yarlett, N., Jacobs R. (2011) SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei. Bioorg Med Chem Letts. 21:2816-2819.
  9. Mayence, A., Vanden Eynde, J. J., Kaiser, M., Brun, R., Yarlett, N. and Huang, T. L. (2011). Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorg Med Chem 19(24): 7493-7500.
  10. Morada, M., Manzur, M., Lam, B., Tan, C., Tachezy, J., Rappelli, P., Dessi, D., Fiori, P. L. and Yarlett, N. (2010). Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis. Microbiology 156(Pt 12): 3734-3743.
  11. Nare, B., Wring, S., Bacchi, C., Beaudet, B., Bowling, T., Brun, R., Chen, D., Ding, C., Freund, Y., Gaukel, E., Hussain, A., Jarnagin, K., Jenks, M., Kaiser, M., Mercer, L., Mejia, E., Noe, A., Orr, M., Parham, R., Plattner, J., Randolph, R., Rattendi, D., Rewerts, C., Sligar, J., Yarlett, N., Don, R. and Jacobs, R. (2010). Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother 54(10): 4379-4388.
  12. Huang, T. L., Vanden Eynde, J. J., Mayence, A., Collins, M. S., Cushion, M. T., Rattendi, D., Londono, I., Mazumder, L., Bacchi, C. J. and Yarlett, N. (2009). Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorg Med Chem Lett 19(20): 5884-5886.
  13. Bacchi, C.J., Yarlett, N., Faciane, E., Bi, X., Rattendi, D., Weiss and Woster, P. (2009) Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimic Ag Chemother 53:2599-2604.
  14. Lantsmanm, Y., Tan, K. S. W., Morada, M. and Yarlett, N. (2008) Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7. Microbiology 154:2757-2766.
  15. Yarlett, N., Wu, G., Waters, W. R., Harp, J. A., Wannemuehler, M. J., Morada, M., Athanasopoulos, D., Martinez, M. P., Upton, S. J., Marton, L. J. and Frydman, B. J. (2007). Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. Mol Biochem Parasitol 152(2): 170-180.
  16. Cook, T., Roos, D., Morada, M., Zhu, G., Keithly, J. S., Feagin, J. E., Wu, G. and Yarlett, N. (2007). Divergent polyamine metabolism in the Apicomplexa. Microbiology 153(Pt 4): 1123-1130.
  17. Yarlett N, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Bellcastro J, Upton SJ, Marton, L. J. and Frydman, B. J. (2007) Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha deficient mouse model. Antimic. Ag. Chemother 51:1234-1239.
1 Protocol published
Long-term in vitro Culture of Cryptosporidium parvum
Authors:  Nigel Yarlett and Mary Morada, date: 08/05/2018, view: 6116, Q&A: 0
Continuous in vitro growth of Cryptosporidium parvum has proved difficult and conventional in vitro culture techniques result in short-term (2-5 days) growth of the parasite resulting in thin-walled oocysts that fail to ...
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