Akira Karasawa New York Structural Biology Center
5 protocols

Alba Blesa Universidad Francisco de Vitoria
17 protocols

David Cisneros Umeå University
30 protocols

HongLok Lung University of Hong Kong
61 protocols

Editor
Tomas Aparicio
  • Research scientist, Columbia University
Research focus
  • Molecular biology
  • DNA replication, DNA repair, DNA damage signaling, chromatin

Education

PhD, 2010

Lab information

DR. JEAN GAUTIER LAB
http://asp.cumc.columbia.edu/facdb/profile_list.asp?DepAffil=Genetics&uni=jg130

Publications

http://orcid.org/0000-0001-5492-4733
Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME,
Gautier J. Nuclear ARP2/3 drives DNA break clustering for homology-directed
repair. Nature. 2018 Jul;559(7712):61-66. doi: 10.1038/s41586-018-0237-5. Epub
2018 Jun 20. PMID: 29925947; PMCID: PMC6145447.

Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice
and cancer. DNA Repair (Amst). 2014 Jul;19:169-75. doi:
10.1016/j.dnarep.2014.03.014. Epub 2014 Apr 18. PMID: 24746645; PMCID:
PMC4051845.

Aparicio T, Gautier J. BRCA1-CtIP interaction in the repair of DNA double-
strand breaks. Mol Cell Oncol. 2016 Mar 30;3(4):e1169343. doi:
10.1080/23723556.2016.1169343. PMID: 27652321; PMCID: PMC4972120.

Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate
repair of topoisomerase II-DNA adducts. J Cell Biol. 2016 Feb 15;212(4):399-408.
doi: 10.1083/jcb.201504005. PMID: 26880199; PMCID: PMC4754713.

Aparicio T, Gautier J. More tasks for Dna2 in S-phase. Cell Cycle. 2012 Dec
1;11(23):4299-300. doi: 10.4161/cc.22807. Epub 2012 Nov 16. PMID: 23159855;
PMCID: PMC3552907.

Aparicio T, Megías D, Méndez J. Visualization of the MCM DNA helicase at
replication factories before the onset of DNA synthesis. Chromosoma. 2012
Oct;121(5):499-507. doi: 10.1007/s00412-012-0381-x. Epub 2012 Aug 22. PMID:
22911457.

Aparicio T, Guillou E, Coloma J, Montoya G, Méndez J. The human GINS complex
associates with Cdc45 and MCM and is essential for DNA replication. Nucleic
Acids Res. 2009 Apr;37(7):2087-95. doi: 10.1093/nar/gkp065. Epub 2009 Feb 17.
PMID: 19223333; PMCID: PMC2673421.

Boskovic J, Coloma J, Aparicio T, Zhou M, Robinson CV, Méndez J, Montoya G.
Molecular architecture of the human GINS complex. EMBO Rep. 2007
Jul;8(7):678-84. doi: 10.1038/sj.embor.7401002. Epub 2007 Jun 8. PMID: 17557111;
PMCID: PMC1905900.

Aparicio T, Ibarra A, Méndez J. Cdc45-MCM-GINS, a new power player for DNA
replication. Cell Div. 2006 Aug 24;1:18. doi: 10.1186/1747-1028-1-18. PMID:
16930479; PMCID: PMC1564009.
7 Protocols reviewed
Cluster Analysis of Endogenous HER2 and HER3 Receptors in SKBR3 Cells
The Human Epidermal Growth Factor Receptor (HER) family of receptor tyrosine kinases consists of four, single pass, transmembrane receptor homologs (HER1-4) that act to regulate many critical processes in normal and tumor cells. HER2 is ...
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Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples
Authors:  Urszula Lucja McClurg, Stuart R McCracken, Lisa Butler, Karl T Riabowol and Olivier Binda, date: 11/05/2018, view: 2219, Q&A: 0
To assess oncogenic potential, classical transformation assays are based on cell line models. However, cell line based models do not reflect the complexity of human tissues. We thus developed an inducible expression system for gene expression in ex ...
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