Angel Nebreda Institute for Research in Biomedicine (IRB Barcelona), Spain
2 protocols
Andrea Introini Karolinska Institutet
8 protocols

Antoine de Morree Stanford university
28 protocols

Lee-Hwa Tai Universite de Sherbrooke
20 protocols

Ralph Boettcher Max Planck Institute for Biochemistry
25 protocols

Jalaj Gupta
  • Georg Speyer Haus
Research focus
  • Cancer biology
  • Animal models, Cancer biology, Colorectal cancer, intestinal stem cells, cell plasticity
  • 2 Author merit




1. van Wijk, S. J. L., Fricke, F., Herhaus, L., Gupta, J., Hotte, K., Pampaloni, F., Grumati, P., Kaulich, M., Sou, Y. S., Komatsu, M., et al. (2017). Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. Nat Microbiol 2, 17066.
2. Diamanti, M. A.*, Gupta, J.*, Bennecke, M., De Oliveira, T., Ramakrishnan, M., Braczynski, A. K., Richter, B., Beli, P., Hu, Y., Saleh, M., et al. (2017). IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 214, 423-437.
*equal contribution
3. Igea, A., Gupta, J., and Nebreda, A. R. (2015). Targeting of non-oncogene addiction. Aging (Albany NY) 7(8):525-6.
4. Gupta, J., and Nebreda, A.R. (2015). Roles of p38 MAPK in mouse models of inflammatory diseases and cancer. FEBS J 282(10):1841-1857.
5. Gupta, J*., Igea, A*, Papaioannou, M., Lopez-Casas, P.P., Llonch, E., Hidalgo, M., Gorgoulis, V.G., and Nebreda, A.R. (2015). Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget 6(11):8539-8551.
*equal contribution
6. Gupta, J., del Barco Barrantes, I., Igea, A., Sakellariou, S., Gorgoulis, V. G., and Nebreda, A. R. (2014). Dual function of p38 MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 25, 484-500.
7. Llopis, A., Salvador, N., Ercilla, A., Guaita-Esteruelas, S., Barrantes Idel, B., Gupta, J., Gaestel, M., Davis, R. J., Nebreda, A. R., and Agell, N. (2012). The stress-activated protein kinases p38alpha/beta and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Cell Cycle 11, 3627-3637.
7. Nagarajan, M., Kumar, N., Nishanth, G., Haribaskar, R., Paranthaman, K., Gupta, J., Mishra, M., Vaidhegi, R., Kumar, S., and Ranjan, A. K. (2009). Microsatellite markers of water buffalo, Bubalus bubalis--development, characterisation and linkage disequilibrium studies. BMC Genetics 10, 68.
8. Ramirez, J. L., Salazar, M. F., Gupta, J., Sanchez, J. M., Taron, M., Sanchez-Ronco, M., Alberola, V., and De las Penas, R. (2006). Methylation patterns and chemosensitivity in NSCLC. Advances in Experimental Medicine and Biology 587, 195-209.
9. Kumar, S., Gupta, J., Kumar, N., Dikshit, K., Navani, N., Jain, P., and Nagarajan, M. (2006). Genetic variation and relationships among eight Indian riverine buffalo breeds. Molecular Ecology 15, 593-600.
10. Thangaraj, K., Sridhar, V., Kivisild, T., Reddy, A. G., Chaubey, G., Singh, V. K., Kaur, S., Agarawal, P., Rai, A., Gupta, J., et al. (2005). Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations. Human Genetics 116, 507-517.

2 Protocols published
Induction of Colitis and Colitis-associated Colorectal Cancer (CAC)
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 6790, Q&A: 0
Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis are characterized by chronic, progressive and relapsing inflammatory disorders. Existing evidence indicate that IBD is associated with a higher risk of developing CAC, ...
Analysis of Intestinal Permeability in Mice
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 17429, Q&A: 3
The intestinal epithelial layer serves as a barrier against pathogens and ingested toxins, which are present in the lumen of the intestine. The importance of the intestinal epithelial barrier is emphasized by the alterations in paracellular ...
7 Protocols reviewed
Muscle Histology Characterization Using H&E Staining and Muscle Fiber Type Classification Using Immunofluorescence Staining
Authors:  Chao Wang, Feng Yue and Shihuan Kuang, date: 05/20/2017, view: 2926, Q&A: 0
Muscle function is determined by its structure and fiber type composition. Here we describe a protocol to examine muscle histology and myofiber types using hematoxylin and eosin (H&E) and immunofluorescence staining, respectively. H&E stain nucleus ...
More >
Isolation of Mononuclear Cell Populations from Ovarian Carcinoma Ascites
Ovarian cancer is one of the most fatal tumors in women. Due to a lack of symptoms and adequate screening methods, patients are diagnosed at advanced stages with extensive tumor burden (Jelovac and Armstrong, 2011). Interestingly, ovarian cancer ...
More >