Search
Coauthors
Angel Nebreda Institute for Research in Biomedicine (IRB Barcelona), Spain
2 protocols
Coreviewers
Andrea Introini Karolinska Institutet
8 protocols

Antoine de Morree Stanford university
32 protocols

Cody Kime Center of Developmental Biology, RIKEN
2 protocols

Lee-Hwa Tai Universite de Sherbrooke
20 protocols

Reviewer
Jalaj Gupta
  • Georg Speyer Haus
Research focus
  • Cancer biology
  • Animal models, Cancer biology, Colorectal cancer, intestinal stem cells, cell plasticity
  • 2 Author merit

Education

PhD

Publications

1. van Wijk, S. J. L., Fricke, F., Herhaus, L., Gupta, J., Hotte, K., Pampaloni, F., Grumati, P., Kaulich, M., Sou, Y. S., Komatsu, M., et al. (2017). Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. Nat Microbiol 2, 17066.
2. Diamanti, M. A.*, Gupta, J.*, Bennecke, M., De Oliveira, T., Ramakrishnan, M., Braczynski, A. K., Richter, B., Beli, P., Hu, Y., Saleh, M., et al. (2017). IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 214, 423-437.
*equal contribution
3. Igea, A., Gupta, J., and Nebreda, A. R. (2015). Targeting of non-oncogene addiction. Aging (Albany NY) 7(8):525-6.
4. Gupta, J., and Nebreda, A.R. (2015). Roles of p38 MAPK in mouse models of inflammatory diseases and cancer. FEBS J 282(10):1841-1857.
5. Gupta, J*., Igea, A*, Papaioannou, M., Lopez-Casas, P.P., Llonch, E., Hidalgo, M., Gorgoulis, V.G., and Nebreda, A.R. (2015). Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget 6(11):8539-8551.
*equal contribution
6. Gupta, J., del Barco Barrantes, I., Igea, A., Sakellariou, S., Gorgoulis, V. G., and Nebreda, A. R. (2014). Dual function of p38 MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 25, 484-500.
7. Llopis, A., Salvador, N., Ercilla, A., Guaita-Esteruelas, S., Barrantes Idel, B., Gupta, J., Gaestel, M., Davis, R. J., Nebreda, A. R., and Agell, N. (2012). The stress-activated protein kinases p38alpha/beta and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Cell Cycle 11, 3627-3637.
7. Nagarajan, M., Kumar, N., Nishanth, G., Haribaskar, R., Paranthaman, K., Gupta, J., Mishra, M., Vaidhegi, R., Kumar, S., and Ranjan, A. K. (2009). Microsatellite markers of water buffalo, Bubalus bubalis--development, characterisation and linkage disequilibrium studies. BMC Genetics 10, 68.
8. Ramirez, J. L., Salazar, M. F., Gupta, J., Sanchez, J. M., Taron, M., Sanchez-Ronco, M., Alberola, V., and De las Penas, R. (2006). Methylation patterns and chemosensitivity in NSCLC. Advances in Experimental Medicine and Biology 587, 195-209.
9. Kumar, S., Gupta, J., Kumar, N., Dikshit, K., Navani, N., Jain, P., and Nagarajan, M. (2006). Genetic variation and relationships among eight Indian riverine buffalo breeds. Molecular Ecology 15, 593-600.
10. Thangaraj, K., Sridhar, V., Kivisild, T., Reddy, A. G., Chaubey, G., Singh, V. K., Kaur, S., Agarawal, P., Rai, A., Gupta, J., et al. (2005). Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations. Human Genetics 116, 507-517.
2 Protocols published
Induction of Colitis and Colitis-associated Colorectal Cancer (CAC)
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 8253, Q&A: 0
Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis are characterized by chronic, progressive and relapsing inflammatory disorders. Existing evidence indicate that IBD is associated with a higher risk of developing CAC, ...
Analysis of Intestinal Permeability in Mice
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 22715, Q&A: 7
The intestinal epithelial layer serves as a barrier against pathogens and ingested toxins, which are present in the lumen of the intestine. The importance of the intestinal epithelial barrier is emphasized by the alterations in paracellular ...
9 Protocols reviewed
In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells
Authors:  Xueqian Zhuang and Guohong Hu, date: 06/05/2018, view: 702, Q&A: 1
Osteoclasts are a group of bone-absorbing cells to degenerate bone matrix and play pivotal roles in bone growth and homeostasis. The unbalanced induction of osteoclast differentiation (osteoclastogenesis) in pathological conditions, such as ...
More >
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas
Authors:  Roberto Würth, Alessandra Pattarozzi, Federica Barbieri and Tullio Florio, date: 04/05/2018, view: 960, Q&A: 0
Pituitary adenomas are among the more frequent intracranial tumors usually treated with both surgical and pharmacological–based on somatostatin and dopamine agonists–approaches. Although mostly benign tumors, the occurrence of invasive behaviors is ...
More >