Angel Nebreda Institute for Research in Biomedicine (IRB Barcelona), Spain
2 protocols
Andrea Introini Karolinska Institutet
10 protocols

Antoine de Morree Stanford university
36 protocols

Cody Kime Center of Developmental Biology, RIKEN
2 protocols

Irit Adini Harvard Medical School
6 protocols

Jalaj Gupta
  • Faculty, Stem Cell Research Center (SCRC), Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow
Research focus
  • Cancer biology
  • Animal models, Cancer biology, Colorectal cancer, intestinal stem cells, cell plasticity
  • 2 Author merit




1. Gandhi, S., Gupta, J., and Tripathi, P. P. (2019). The Curious Case of Human Hippocampal Neurogenesis. ACS Chem Neurosci 10, 1131-1132.
2. Tripathi P.P., Arami H., Banga I., Gupta J., and Gandhi S. (2018). Cell Penetrating Peptides in Preclinical and Clinical Cancer Diagnosis and Therapy. Oncotarget 9(98):37252-37267.
3. Canli, Ö., Nicolas A.M.*, Gupta, J. *, Finkelmeier, F.*, Goncharova, O., Pesic, M., Neumann, T., Horst, D., Löwer, M., Sahin, U., and Greten, F.R. (2017). Myeloid cell-derived reactive oxygen species induce epithelial mutagenesis. Cancer Cell. 32, 869-883.
* These authors contributed equally
(Cover article for December, 2017 issue of Cancer Cell, preview of this article was published in Cancer Cell. 2017 32(6):727-729)
4. van Wijk, S. J. L., Fricke, F., Herhaus, L., Gupta, J., Hotte, K., Pampaloni, F., Grumati, P., Kaulich, M., Sou, Y. S., Komatsu, M., et al. (2017). Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. Nat Microbiol 2, 17066.
5. Diamanti, M. A.*, Gupta, J.*, Bennecke, M., De Oliveira, T., Ramakrishnan, M., Braczynski, A. K., Richter, B., Beli, P., Hu, Y., Saleh, M., et al. (2017). IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 214, 423-437.
*equal contribution
6. Igea, A., Gupta, J., and Nebreda, A. R. (2015). Targeting of non-oncogene addiction. Aging (Albany NY) 7(8):525-6.
7. Gupta, J., and Nebreda, A.R. (2015). Roles of p38 MAPK in mouse models of inflammatory diseases and cancer. FEBS J 282(10):1841-1857.
8. Gupta, J*., Igea, A*, Papaioannou, M., Lopez-Casas, P.P., Llonch, E., Hidalgo, M., Gorgoulis, V.G., and Nebreda, A.R. (2015). Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget 6(11):8539-8551.
*equal contribution
9. Gupta, J., del Barco Barrantes, I., Igea, A., Sakellariou, S., Gorgoulis, V. G., and Nebreda, A. R. (2014). Dual function of p38 MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 25, 484-500.
10. Llopis, A., Salvador, N., Ercilla, A., Guaita-Esteruelas, S., Barrantes Idel, B., Gupta, J., Gaestel, M., Davis, R. J., Nebreda, A. R., and Agell, N. (2012). The stress-activated protein kinases p38alpha/beta and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Cell Cycle 11, 3627-3637.
11. Nagarajan, M., Kumar, N., Nishanth, G., Haribaskar, R., Paranthaman, K., Gupta, J., Mishra, M., Vaidhegi, R., Kumar, S., and Ranjan, A. K. (2009). Microsatellite markers of water buffalo, Bubalus bubalis--development, characterisation and linkage disequilibrium studies. BMC Genetics 10, 68.
12. Ramirez, J. L., Salazar, M. F., Gupta, J., Sanchez, J. M., Taron, M., Sanchez-Ronco, M., Alberola, V., and De las Penas, R. (2006). Methylation patterns and chemosensitivity in NSCLC. Advances in Experimental Medicine and Biology 587, 195-209.
13. Kumar, S., Gupta, J., Kumar, N., Dikshit, K., Navani, N., Jain, P., and Nagarajan, M. (2006). Genetic variation and relationships among eight Indian riverine buffalo breeds. Molecular Ecology 15, 593-600.
14. Thangaraj, K., Sridhar, V., Kivisild, T., Reddy, A. G., Chaubey, G., Singh, V. K., Kaur, S., Agarawal, P., Rai, A., Gupta, J., et al. (2005). Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations. Human Genetics 116, 507-517.
2 Protocols published
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 13295, Q&A: 0
Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis are characterized by chronic, progressive and relapsing inflammatory disorders. Existing evidence indicate that IBD is associated with a higher risk of developing CAC, ...
Authors:  Jalaj Gupta and Angel R. Nebreda, date: 11/20/2014, view: 40947, Q&A: 7
The intestinal epithelial layer serves as a barrier against pathogens and ingested toxins, which are present in the lumen of the intestine. The importance of the intestinal epithelial barrier is emphasized by the alterations in paracellular ...
10 Protocols reviewed
Dissecting the Rat Mammary Gland: Isolation, Characterization, and Culture of Purified Mammary Epithelial Cells and Fibroblasts

With the advent of CRISPR-Cas and the ability to easily modify the genome of diverse organisms, rat models are being increasingly developed to interrogate the genetic events underlying mammary development and tumorigenesis. Protocols for the

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In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells
Authors:  Xueqian Zhuang and Guohong Hu, date: 06/05/2018, view: 8136, Q&A: 1
Osteoclasts are a group of bone-absorbing cells to degenerate bone matrix and play pivotal roles in bone growth and homeostasis. The unbalanced induction of osteoclast differentiation (osteoclastogenesis) in pathological conditions, such as ...
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