Sebastián Tanco Medical Biotechnology Center, VIB, Belgium
1 protocol

Walter Obregon Centro de Investigación de Proteínas Vegetales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
1 protocol

Francesc Avilés Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Campus Universitari, Bellaterra, Cerdanyola del Vallès, Spain
1 protocol

Laura Bakas Centro de Investigación de Proteínas Vegetales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
1 protocol

Julia Lorenzo
  • Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Campus Universitari, Bellaterra, Cerdanyola del Vallès, Spain
Research focus
  • Plant science
  • 1 Author merit


Ph.D in Biology (Biochemistry), Institut de Biotecnologia i de Biomedicina. Universitat Autònoma de Barcelona, 2001

Current Position

Associate Professor in Biochemistry, Molecular Biology, Biomedicine and Nanotechnology. Universitat Autònoma de Barcelona, Barcelona. Spain

Publications (since 2012)

  1. Lorenzo, J. and Montana, A. M. (2016). The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity. J Mol Graph Model 69: 39-60.
  2. Arinez-Soriano, J., Albalad, J., Carne-Sanchez, A., Bonnet, C. S., Busque, F., Lorenzo, J., Juanhuix, J., Terban, M. W., Imaz, I., Toth, E. and Maspoch, D. (2016). pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate. Chemistry 22(37): 13162-13170.
  3. Contreras Rodríguez, A. R., Saiz-Poseu, J., García-Pardo, J., García, B., Lorenzo, J., Ojea-Jiménez, I., Komilis, D., Sedó, J., Busqué, F., Sánchez, A., Ruiz-Molina, D. and Font, X. (2016). Biocompatible polydopamine-like particles for the removal of heavy metals at extremely low concentrations. RSC Adv 6: 40058-40066.
  4. Lufrano, D., Cotabarren, J., Garcia-Pardo, J., Fernandez-Alvarez, R., Tort, O., Tanco, S., Aviles, F. X., Lorenzo, J. and Obregon, W. D. (2015). Biochemical characterization of a novel carboxypeptidase inhibitor from a variety of Andean potatoes. Phytochemistry 120: 36-45.
  5. Borges, M., Yu, S., Laromaine, A., Roig, A., Suárez-García, S., Lorenzo, J., Ruiz-Molina, D. and Novio, F. (2015). Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles. RSC Adv 5: 86779–86783.
  6. Miserachs, H. G., Cipriani, M., Grau, J., Vilaseca, M., Lorenzo, J., Medeiros, A., Comini, M. A., Gambino, D., Otero, L. and Moreno, V. (2015). Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands. J Inorg Biochem 150: 38-47.
  7. Fait, M. E., Garrote, G. L., Clapes, P., Tanco, S., Lorenzo, J. and Morcelle, S. R. (2015). Biocatalytic synthesis, antimicrobial properties and toxicity studies of arginine derivative surfactants. Amino Acids 47(7): 1465-1477.
  8. Correia, I., Roy, S., Matos, C. P., Borovic, S., Butenko, N., Cavaco, I., Marques, F., Lorenzo, J., Rodriguez, A., Moreno, V. and Pessoa, J. C. (2015). Vanadium(IV) and copper(II) complexes of salicylaldimines and aromatic heterocycles: Cytotoxicity, DNA binding and DNA cleavage properties. J Inorg Biochem 147: 134-146.
  9. Ruyra, A., Yazdi, A., Espin, J., Carne-Sanchez, A., Roher, N., Lorenzo, J., Imaz, I. and Maspoch, D. (2015). Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal-organic framework nanoparticles. Chemistry 21(6): 2508-2518.
  10. Tanco, S., Tort, O., Demol, H., Aviles, F. X., Gevaert, K., Van Damme, P. and Lorenzo, J. (2015). C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics 14(1): 177-190.
  11. Garcia-Pardo, J., Grana-Montes, R., Fernandez-Mendez, M., Ruyra, A., Roher, N., Aviles, F. X., Lorenzo, J. and Ventura, S. (2014). Amyloid formation by human carboxypeptidase D transthyretin-like domain under physiological conditions. J Biol Chem 289(49): 33783-33796.
  12. Novio, F., Lorenzo, J., Nador, F., Wnuk, K. and Ruiz-Molina, D. (2014). Group (-CO2H) functionalized coordination polymer nanoparticles as efficient platforms for drug delivery. Chemistry A 20(47): 15443-15450.
  13. Tort, O., Tanco, S., Rocha, C., Bieche, I., Seixas, C., Bosc, C., Andrieux, A., Moutin, M. J., Aviles, F. X., Lorenzo, J. and Janke, C. (2014). The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Mol Biol Cell 25(19): 3017-3027.
  14. Lorenzo, J., Delgado, A., Montana, A. M., Mesas, J. M., Alegre, M. T., Rodriguez Mdel, C. and Aviles, F. X. (2014). Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes. Eur J Med Chem 83: 374-388.
  15. Nunez, C., Oliveira, E., Garcia-Pardo, J., Diniz, M., Lorenzo, J., Capelo, J. L. and Lodeiro, C. (2014). A novel quinoline molecular probe and the derived functionalized gold nanoparticles: sensing properties and cytotoxicity studies in MCF-7 human breast cancer cells. J Inorg Biochem 137: 115-122.
  16. Duran, M., Salas, E., Cano, L. M., Moneriz, C. E., Mendez, D. M., Lorenzo, J., Piermattey, J., Montalvo, J., Bautista Jose, M. and Gaitan, R. (2014). Quinoid Compounds Cause Inhibition of Falcipain 2, and Arrest Plasmodium falciparum Growth in Vitro. Lat Am J Pharm 33(4): 666-674.
  17. Saez, R., Lorenzo, J., Prieto, M. J., Font-Bardia, M., Calvet, T., Omenaca, N., Vilaseca, M. and Moreno, V. (2014). Influence of PPh(3) moiety in the anticancer activity of new organometallic ruthenium complexes. J Inorg Biochem 136: 1-12.
  18. Valente, A., Santos, A. M., Côrte-Real, L., Robalo, M. P., Moreno, V., Font-Bardia, M., Calvet, T., Lorenzo, J., Garcia, M. H. (2014). New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells. J Organomet Chem 756: 52-60.
  19. Oliveira, E., Santos, H. M., Garcia-Pardo, J., Diniz, M., Lorenzo, J., Rodriguez-Gonzalez, B., Capelo, J. L. and Lodeiro, C. (2013). Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells. Front Chem 1: 29.
  20. Carne-Sanchez, A., Bonnet, C. S., Imaz, I., Lorenzo, J., Toth, E. and Maspoch, D. (2013). Relaxometry studies of a highly stable nanoscale metal-organic framework made of Cu(II), Gd(III), and the macrocyclic DOTP. J Am Chem Soc 135(47): 17711-17714.
  21. Tanco, S., Lorenzo, J., Garcia-Pardo, J., Degroeve, S., Martens, L., Aviles, F. X., Gevaert, K. and Van Damme, P. (2013). Proteome-derived peptide libraries to study the substrate specificity profiles of carboxypeptidases. Mol Cell Proteomics 12(8): 2096-2110.
  22. Demoro, B., de Almeida, R. F., Marques, F., Matos, C. P., Otero, L., Costa Pessoa, J., Santos, I., Rodriguez, A., Moreno, V., Lorenzo, J., Gambino, D. and Tomaz, A. I. (2013). Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism. Dalton Trans 42(19): 7131-7146.
  23. Escribano, E., Font-Bardia, M., Calvet, T., Lorenzo, J., Gamez, P. and Moreno, V. (2013). DNA Binding Studies of a Series of cis-[Pt(Am)2X2] Complexes (Am = inert amine, X = labile carboxylato ligand). Inorg Chim Acta 394: 65-77.
  24. Rodriguez de la Vega Otazo, M., Lorenzo, J., Tort, O., Aviles, F. X. and Bautista, J. M. (2013). Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). FASEB J 27(2): 424-431.
  25. Aznar, R., Grabulosa, A., Mannu, A., Muller, G., Sainz, D., Moreno, V., Font-Bardia, M., Calvet, T. and Lorenzo, J. (2012). [RuCl2(η6‑p‑cymene)(P*)] and [RuCl2(κ-P*‑η6‑arene)] Complexes Containing P-Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA. Organometallics 32(8): 2344-2362.
  26. Lin, V. S. and Chang, C. J. (2012). Fluorescent probes for sensing and imaging biological hydrogen sulfide. Curr Opin Chem Biol 16(5-6): 595-601.
  27. Ojea-Jiménez, I., Lorenzo, J., Rebled, J., Sendra, J., Arbiol, J. and Puntes, V. (2012). Synthesis of Co-organosilane-Au nanocomposites via a controlled interphasic reduction. Chemistry of Materials 24(21): 4019-4027.
  28. Ojea-Jimenez, I., Tort, O., Lorenzo, J. and Puntes, V. F. (2012). Engineered nonviral nanocarriers for intracellular gene delivery applications. Biomed Mater 7(5): 054106.
  29. Ojea-Jimenez, I., Garcia-Fernandez, L., Lorenzo, J. and Puntes, V. F. (2012). Facile preparation of cationic gold nanoparticle-bioconjugates for cell penetration and nuclear targeting. ACS Nano 6(9): 7692-7702.
  30. Otero, A., Rodriguez de la Vega, M., Tanco, S., Lorenzo, J., Aviles, F. X. and Reverter, D. (2012). The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs. FASEB J 26(9): 3754-3764.
1 Protocol published
Microplate Assay to Study Carboxypeptidase A Inhibition in Andean Potatoes
Metallocarboxypeptidases (MCP) are zinc-dependent exopeptidases that catalyze the hydrolysis of C-terminal amide bonds in proteins and peptides. They are involved in a wide range of physiological processes and have recently emerged as relevant drug ...
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