BERTA CASAR Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria (UC), Spain
1 protocol
Ching Yao Yang New York University
5 protocols

Piero Crespo
  • Consejo Superior de Investigaciones Científicas
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D in Biological Sciences , Department of Molecular Biology, University of Cantabria (SPAIN), 1991

Current position

Professor and Director of Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC) , Consejo Superior de Investigaciones Científicas (CSIC)

Publications (since 2005)

  1. Herrero, A. and Crespo, P. (2016). Tumors topple when ERKs uncouple. Mol Cell Oncol 3(2): e1091875.

  2. Casar, B. and Crespo, P. (2016). ERK Signals: Scaffolding Scaffolds? Front Cell Dev Biol 4: 49.

  3. Herrero, A., Casar, B., Colon-Bolea, P., Agudo-Ibanez, L. and Crespo, P. (2016). Defined spatiotemporal features of RAS-ERK signals dictate cell fate in MCF-7 mammary epithelial cells. Mol Biol Cell 27(12): 1958-1968.

  4. Munoz-Felix, J. M., Fuentes-Calvo, I., Cuesta, C., Eleno, N., Crespo, P., Lopez-Novoa, J. M. and Martinez-Salgado, C. (2016). Absence of K-Ras Reduces Proliferation and Migration But Increases Extracellular Matrix Synthesis in Fibroblasts. J Cell Physiol 231(10): 2224-2235.

  5. Herrero, A., Pinto, A., Colon-Bolea, P., Casar, B., Jones, M., Agudo-Ibanez, L., Vidal, R., Tenbaum, S. P., Nuciforo, P., Valdizan, E. M., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H. G., Hurlstone, A. and Crespo, P. (2015). Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 28(2): 170-182.

  6. Agudo-Ibanez, L., Herrero, A., Barbacid, M. and Crespo, P. (2015). H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Mol Cell Biol 35(11): 1898-1914.

  7. Colon-Bolea, P. and Crespo, P. (2014). Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway. Bioessays 36(12): 1162-1169.

  8. Baschieri, F., Confalonieri, S., Bertalot, G., Di Fiore, P. P., Dietmaier, W., Leist, M., Crespo, P., Macara, I. G. and Farhan, H. (2014). Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun 5: 4839.

  9. Fuentes-Calvo, I., Crespo, P., Santos, E., Lopez-Novoa, J. M. and Martinez-Salgado, C. (2013). The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts. Biochim Biophys Acta 1833(12): 2734-2744.

  10. Casar, B., Rodriguez, J., Gibor, G., Seger, R. and Crespo, P. (2012). Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases. Biochem J 441(2): 571-578.

  11. Matallanas, D., Romano, D., Al-Mulla, F., O'Neill, E., Al-Ali, W., Crespo, P., Doyle, B., Nixon, C., Sansom, O., Drosten, M., Barbacid, M. and Kolch, W. (2011). Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell 44(6): 893-906.

  12. Crespo, P., Calvo, F. and Sanz-Moreno, V. (2011). Ras and Rho GTPases on the move: The RasGRF connection. Bioarchitecture 1(4): 200-204.

  13. Rodriguez, J. and Crespo, P. (2011). Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci Signal 4(196): re3.

  14. Arozarena, I., Calvo, F. and Crespo, P. (2011). Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer 2(3): 182-194.

  15. Calvo, F., Sanz-Moreno, V., Agudo-Ibanez, L., Wallberg, F., Sahai, E., Marshall, C. J. and Crespo, P. (2011). RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol 13(7): 819-826.

  16. Matallanas, D. and Crespo, P. (2010). New druggable targets in the Ras pathway? Curr Opin Mol Ther 12(6): 674-683.

  17. Rodriguez, J., Calvo, F., Gonzalez, J. M., Casar, B., Andres, V. and Crespo, P. (2010). ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol 191(5): 967-979.

  18. Pinto, A. and Crespo, P. (2010). Analysis of ERKs' dimerization by electrophoresis. Methods Mol Biol 661: 335-342.

  19. Chiariello, M., Vaque, J. P., Crespo, P. and Gutkind, J. S. (2010). Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. Methods Mol Biol 661: 137-150.

  20. Calvo, F., Agudo-Ibanez, L. and Crespo, P. (2010). The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies. Bioessays 32(5): 412-421.

  21. Calvo, F. and Crespo, P. (2009). Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Mol Biol Cell 20(20): 4289-4302.

  22. Casar, B., Pinto, A. and Crespo, P. (2009). ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task. Cell Cycle 8(7): 1007-1013.

  23. Casar, B., Arozarena, I., Sanz-Moreno, V., Pinto, A., Agudo-Ibanez, L., Marais, R., Lewis, R. E., Berciano, M. T. and Crespo, P. (2009). Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol 29(5): 1338-1353.

  24. Gonzalez, J. M., Navarro-Puche, A., Casar, B., Crespo, P. and Andres, V. (2008). Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol 183(4): 653-666.

  25. Casar, B., Pinto, A. and Crespo, P. (2008). Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes. Mol Cell 31(5): 708-721.

  26. Vaque, J. P., Fernandez-Garcia, B., Garcia-Sanz, P., Ferrandiz, N., Bretones, G., Calvo, F., Crespo, P., Marin, M. C. and Leon, J. (2008). c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation. Mol Cancer Res 6(2): 325-339.

  27. Agudo-Ibanez, L., Nunez, F., Calvo, F., Berenjeno, I. M., Bustelo, X. R. and Crespo, P. (2007). Transcriptomal profiling of site-specific Ras signals. Cell Signal 19(11): 2264-2276.

  28. Martinez, S. E., Lazaro-Dieguez, F., Selva, J., Calvo, F., Piqueras, J. R., Crespo, P., Claro, E. and Egea, G. (2007). Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. J Neurochem 102(4): 1044-1052.

  29. Casar, B., Sanz-Moreno, V., Yazicioglu, M. N., Rodriguez, J., Berciano, M. T., Lafarga, M., Cobb, M. H. and Crespo, P. (2007). Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J 26(3): 635-646.

  30. Peregrin, S., Jurado-Pueyo, M., Campos, P. M., Sanz-Moreno, V., Ruiz-Gomez, A., Crespo, P., Mayor, F., Jr. and Murga, C. (2006). Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 16(20): 2042-2047.

  31. Bernal, J. and Crespo, P. (2006). Analysis of Rhes activation state and effector function. Methods Enzymol 407: 535-542.

  32. Matallanas, D., Sanz-Moreno, V., Arozarena, I., Calvo, F., Agudo-Ibanez, L., Santos, E., Berciano, M. T. and Crespo, P. (2006). Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol 26(1): 100-116.

  33. Vaque, J. P., Navascues, J., Shiio, Y., Laiho, M., Ajenjo, N., Mauleon, I., Matallanas, D., Crespo, P. and Leon, J. (2005). Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway. J Biol Chem 280(2): 1112-1122.

1 Protocol published
The Chick Embryo Chorioallantoic Membrane as an in vivo Model to Study Metastasis
Authors:  Piero Crespo and Berta Casar, date: 10/20/2016, view: 17584, Q&A: 0
Metastasis is a complex process that includes several steps: neoplastic progression, angiogenesis, cell migration and invasion, intravasation into nearby blood vessels, survival in the circulatory system, extravasation followed by homing into ...
1 Protocol reviewed
A mant-GDP Dissociation Assay to Compare the Guanine Nucleotide Binding Preference of Small GTPases
Authors:  Yuping Tan and Qingxiang Sun, date: 01/20/2021, view: 1989, Q&A: 0

Small GTPases are cellular switches that are switched on when bound to GTP and switched off when bound to GDP. Different small GTPase proteins or those with mutations may bind to GTP or GDP with different relative affinities. However, small GTPases

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