Zena Werb Department of Anatomy, University of California, USA
2 protocols
Lifeng Liu DOE Joint Genome Institute
4 protocols

Matilda F. Chan
  • University of California
Research focus
  • Molecular biology
  • 2 Author merit


M.D./Ph.D. in Biochemistry, Keck/University of Southern California, 2002

Current position

Assistant Professor, Ophthalmology, School of Medicine, University of California, San Francisco, USA


  1. Chan, M. F., Li, J., Bertrand, A., Casbon, A. J., Lin, J. H., Maltseva, I. and Werb, Z. (2013). Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci 126(Pt 17): 3948-3960.
  2. Maltseva, I., Chan, M., Kalus, I., Dierks, T. and Rosen, S. D. (2013). The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One 8(8): e69642.
  3. Dalmon, C., Porco, T. C., Lietman, T. M., Prajna, N. V., Prajna, L., Das, M. R., Kumar, J. A., Mascarenhas, J., Margolis, T. P., Whitcher, J. P., Jeng, B. H., Keenan, J. D., Chan, M. F., McLeod, S. D. and Acharya, N. R. (2012). The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci 53(4): 1787-1791.
  4. Oldenburg, C. E., Keenan, J. D., Cevallos, V., Chan, M. F., Acharya, N. R., Gaynor, B. D., McLeod, S. D., Esterberg, E. J., Porco, T. C. and Lietman, T. M. (2011). Microbiological cure times in acanthamoeba keratitis. Eye (Lond) 25(9): 1155-1160.
  5. Chan, M. F., Sack, R., Quigley, D. A., Sathe, S., Vijmasi, T., Li, S., Holsclaw, D., Strauss, E. C. and McNamara, N. A. (2011). Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci 88(8): 1005-1009.
  6. Hu, A. Y., Strauss, E. C., Holland, G. N., Chan, M. F., Yu, F. and Margolis, T. P. (2010). Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol 149(2): 214-220 e213.
  7. Rutar, T., Chan, M. F., Acharya, N. R. and Naseri, A. (2007). Cicatrising conjunctivitis due to paraneoplastic pemphigoid. Br J Ophthalmol 91(11): 1562-1563.
  8. Sappington, R. M., Chan, M. and Calkins, D. J. (2006). Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci 47(7): 2932-2942.
  9. Liang, G.*, Chan, M. F.*, Tomigahara, Y., Tsai, Y. C., Gonzales, F. A., Li, E., Laird, P. W. and Jones, P. A. (2002). Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 22(2): 480-491. (*Both authors contributed equally to this work)
  10. Chan, M. F., van Amerongen, R., Nijjar, T., Cuppen, E., Jones, P. A. and Laird, P. W. (2001). Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol 21(22): 7587-7600.
  11. Simoneau, A. R., Spruck, C. H., 3rd, Gonzalez-Zulueta, M., Gonzalgo, M. L., Chan, M. F., Tsai, Y. C., Dean, M., Steven, K., Horn, T. and Jones, P. A. (1996). Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res 56(21): 5039-5043.

Review articles

  1. Chan, M. F., Liang, G. and Jones, P. A. (2000). Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol 249: 75-86.

Books and chapters

  1. Chan, M. F. and Ching, S. T. (2007). Infectious mononucleosis (Epstein-Barr Virus). In: Roy, F. H., Fraunfelder, F. T. and Fraunfelder, F. W. (eds). Current ocular therapy, 6 th Edition. London: Elsevier Limited.
2 Protocols published
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 10076, Q&A: 0
The accessibility and transparency of the cornea makes it a good tissue model for monitoring immunological responses using in vivo real time imaging analysis (Lee et al., 2010; Tan et al., 2013). These corneal qualities ...
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 8509, Q&A: 0
The cornea is an excellent model system to use for the analysis of wound repair because of its accessibility, lack of vascularization, and simple anatomy. Corneal injuries may involve only the superficial epithelial layer or may penetrate deeper to ...
1 Protocol reviewed
Identification of Intrinsic RNA Binding Specificity of Purified Proteins by in vitro RNA Immunoprecipitation (vitRIP)
Authors:  Marisa Müller, Tamas Schauer and Peter B. Becker, date: 03/05/2021, view: 1557, Q&A: 0

RNA-protein interactions are often mediated by dedicated canonical RNA binding domains. However, interactions through non-canonical domains with unknown specificity are increasingly observed, raising the question how RNA targets are recognized.

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