Education

PhD, National University of Cordoba, 2008

Lab information

Guillermo Gomez's lab

Research interest: Physical forces are a key determinant of tissue architecture controlling also cellular behaviours that range from the differentiation of stem cells to cell transformation and cancer invasion. We have made significant progress in understanding the mechanisms involved in capacity of the cells to generate forces and the regulation of epithelial organization. We now are using this knowledge to understand how dysregulation of tissue mechanics contributes to the loss of tissue architecture and organ function.
https://ccb.unisa.edu.au/research/laboratories/Tissue_Architecture_and_Organ_Function_Laboratory/

Publications

Selected publications
1. Priya R, Liang X, Teo JL, Duszyc K., Yap AS and Gomez GA*. 2017. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA mediated contractility at the epithelial zonula adherens. Molecular Biology of the Cell 2017. 28(1):12-20. *Corresponding Author
2. Acharya BR, Wu SK, Lieu ZZ, Parton RG, Grill SW, Bershadsky AD, Gomez GA, Yap AS. 2017. Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility. Cell Reports. 18 (12), 2854-2867
3. Priya R*, Gomez GA*, Budnar S, Acharya BR, Czirok A, Yap AS, Neufeld Z. 2017. Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. PLoS Computational Biology 13 (3), e1005411 *Co-first authors
4. Coburn L, Lopez H, Caldwell BJ, Moussa E, Yap C, Priya R, Noppe A, Roberts AP, Lobaskin V, Yap AS, Neufeld Z, Gomez GA*. 2016. Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates. Molecular Biology of the Cell 27(22):3436-3448 *Corresponding author
5. Michael M, Meiring JC, Acharya BR, Matthews DR, Verma S, Han SP, Hill MM, Parton RG, Gomez GA, Yap AS. 2016. Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions. Developmental Cell. Apr 4;37(1):58-71.
6. Priya R, Gomez GA*, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS*. 2015. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nature Cell Biology 17(10):1282-93. *Corresponding authors
7. Gomez GA*, McLachlan RW, Wu SK, Caldwell BJ, Moussa E, Verma S, Bastiani M, Priya R, Parton RG, Gaus K, Sap J, Yap AS*. 2015. An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Molecular Biology of the Cell. 26(7):1249-62.* Corresponding authors.
8. Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS* and Gomez GA*. 2014. Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens. Cytoskeleton 71:663. *Corresponding Authors.
9. Wu SK, Gomez GA*, Michael M, Verma S, Cox HL, Lefevre JG, Parton RG, Hamilton NA, Neufeld Z, Yap AS*. 2014. Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia. Nature Cell Biology. 16(2):167-78. *Corresponding Authors.
10. Ratheesh A.*, Gomez GA*, Priya R, Verma S, Kovacs EM, Jiang K, Brown NH, Akhmanova A, Stehbens SJ, Yap AS. 2012. Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nature Cell Biology 14(8):818-28.* co-first author.