Cancer Biology

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    Protocols in Current Issue
    3D Co-culture System of Mouse Prostatic Wild-type Fibroblasts with Human Prostate Cancer Epithelial Cells
    Authors:  Veronica R. Placencio-Hickok, Manabu Kato and Neil A. Bhowmick, date: 05/05/2019, view: 427, Q&A: 0
    [Abstract] Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression. This was established using transgenic mouse models. Paracrine interactions between fibroblasts and epithelial cells were further interrogated using isolated 2D cell culture systems, but 3D culture systems currently being developed can better mimic ...
    Capturing the Driving Role of Tumor-host Crosstalk in a Dynamical Model of Tumor Growth
    Authors:  Sebastien Benzekry, Afshin Beheshti, Philip Hahnfeldt and Lynn Hlatky, date: 11/05/2015, view: 5036, Q&A: 0
    [Abstract] In 1999, Hahnfeldt et al. proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the idea that a tumor is supported by a dynamic, rather than a static, carrying capacity. In this original paper, the carrying capacity was equated with the variable ...
    In vitro Tumorsphere Formation Assays
    Authors:  Sara Johnson, Hexin Chen and Pang-Kuo Lo, date: 02/05/2013, view: 40051, Q&A: 3
    [Abstract] A tumorsphere is a solid, spherical formation developed from the proliferation of one cancer stem/progenitor cell. These tumorspheres (Figure 1a) are easily distinguishable from single or aggregated cells (Figure 1b) as the cells appear to become fused together and individual cells cannot be identified. Cells are grown in serum-free, non-adherent ...



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