Education

Ph.D. in Molecular Biology

Current Position

Senior  Principal  Investigator,  Growth-Development-Metabolism  Program  at the Singapore Institute for Clinical Sciences (SICS)

Publications

1. Tan, P. Y., Chang, C. W., Duan, K., Poidinger, M., Ng, K. L., Chong, Y. S., Gluckman, P. D. and Stunkel, W. (2016). E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants. PLoS One 11(9): e0163035.
2. Leow, S. C., Poschmann, J., Too, P. G., Yin, J., Joseph, R., McFarlane, C., Dogra, S., Shabbir, A., Ingham, P. W., Prabhakar, S., Leow, M. K., Lee, Y. S., Ng, K. L., Chong, Y. S., Gluckman, P. D. and Stunkel, W. (2016). The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Development 143(6): 950-961.
3. Joseph, R., Poschmann, J., Sukarieh, R., Too, P. G., Julien, S. G., Xu, F., Teh, A. L., Holbrook, J. D., Ng, K. L., Chong, Y. S., Gluckman, P. D., Prabhakar, S. and Stunkel, W. (2015). ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content. Mol Endocrinol 29(6): 909-920.
4. Sukarieh, R., Joseph, R., Leow, S. C., Li, Y., Loffler, M., Aris, I. M., Tan, J. H., Teh, A. L., Chen, L., Holbrook, J. D., Ng, K. L., Lee, Y. S., Chong, Y. S., Summers, S. A., Gluckman, P. D. and Stunkel, W. (2014). Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells. Hum Reprod 29(10): 2287-2301.
5. Cheong, C. Y., Chng, K., Lim, M. K., Amrithraj, A. I., Joseph, R., Sukarieh, R., Chee Tan, Y., Chan, L., Tan, J. H., Chen, L., Pan, H., Holbrook, J. D., Meaney, M. J., Seng Chong, Y., Gluckman, P. D. and Stunkel, W. (2014). Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes. J Hum Genet 59(9): 504-511.
6. Ong, M. L., Tan, P. Y., MacIsaac, J. L., Mah, S. M., Buschdorf, J. P., Cheong, C. Y., Stunkel, W., Chan, L., Gluckman, P. D., Chng, K., Kobor, M. S., Meaney, M. J. and Holbrook, J. D. (2014). Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis). G3 (Bethesda) 4(7): 1227-1234.
7. Teh, A. L., Pan, H., Chen, L., Ong, M. L., Dogra, S., Wong, J., MacIsaac, J. L., Mah, S. M., McEwen, L. M., Saw, S. M., Godfrey, K. M., Chong, Y. S., Kwek, K., Kwoh, C. K., Soh, S. E., Chong, M. F., Barton, S., Karnani, N., Cheong, C. Y., Buschdorf, J. P., Stünkel, W., Kobor, M. S., Meaney, M. J., Gluckman, P. D. and Holbrook, J. D. (2014). The  effect  of  genotype  and  in  utero  environment  on  interindividual  variation  in neonate  DNA  methylomes. Genome  Res 24(7):1064-­1074.
8. Soh, S. E., Tint, M. T., Gluckman, P. D., Godfrey, K. M., Rifkin-Graboi, A., Chan, Y. H., Stunkel, W., Holbrook, J. D., Kwek, K., Chong, Y. S., Saw, S. M. and Group, G. S. (2014). Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. Int J Epidemiol 43(5): 1401-1409.
9. Pan, H., Chen, L., Dogra, S., Teh, A. L., Tan, J. H., Lim, Y. I., Lim, Y. C., Jin, S., Lee, Y. K., Ng, P. Y., Ong, M. L., Barton, S., Chong, Y. S., Meaney, M. J., Gluckman, P. D., Stunkel, W., Ding, C. and Holbrook, J. D. (2012). Measuring the methylome in clinical samples: improved processing of the Infinium Human Methylation450 BeadChip Array. Epigenetics 7(10): 1173-1187.
10. Stunkel, W., Pan, H., Chew, S. B., Tng, E., Tan, J. H., Chen, L., Joseph, R., Cheong, C. Y., Ong, M. L., Lee, Y. S., Chong, Y. S., Saw, S. M., Meaney, M. J., Kwek, K., Sheppard, A. M., Gluckman, P. D., Group, G. S. and Holbrook, J. D. (2012). Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. PLoS One 7(7): e39744.
11. Stunkel, W. and Campbell, R. M. (2011). Sirtuin 1 (SIRT1): the misunderstood HDAC. J Biomol Screen 16(10): 1153-1169.
12. Wang, H., Yu, N., Song, H., Chen, D., Zou, Y., Deng, W., Lye, P. L., Chang, J., Ng, M., Sun, E. T., Sangthongpitag, K., Wang, X., Wu, X., Khng, H. H., Fang, L., Goh, S. K., Ong, W. C., Bonday, Z., Stünkel, W., Poulsen, A. and Entzeroth, M. (2009). N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity. Bioorg Med Chem Lett 19(5):1403-1408.
13. Stunkel, W., Peh, B. K., Tan, Y. C., Nayagam, V. M., Wang, X., Salto-Tellez, M., Ni, B., Entzeroth, M. and Wood, J. (2007). Function of the SIRT1 protein deacetylase in cancer. Biotechnol J 2(11): 1360-1368.
14. Nayagam, V. M., Wang, X., Tan, Y. C., Poulsen, A., Goh, K. C., Ng, T., Wang, H., Song, H. Y., Ni, B., Entzeroth, M. and Stunkel, W. (2006). SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8): 959-967.
15. Goh, K. C., Wang, H.,Yu, N., Zhou, Y.,Zheng, Y., Lim, Z. Y., Sangthongpitag, K., Fang, L., Du, M., Wang, X., Jefferson,  A. B., Rose, J., Shamoon, B., Reinhard, C., Carte, B., Entzeroth, M., Ni, B., Taylor, M. L. and Stünkel, W. (2004). PLK1 as a potential drug target in cancer therapy. Drug Dev Res 62(4): 349-362.
16. Tan, S. H., Baker, C. C., Stunkel, W. and Bernard, H. U. (2003). A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16. Virology 305(2): 486-501.
17. Stünkel, W., Ait-Si-Ali,S., Jones, P. L. and Wolffe, A. P. (2001). Programming the transcriptional state of replicating methylated DNA. J  Biol Chem 276(23): 20743-­20749.
18. Stunkel, W., Huang, Z., Tan, S. H., O'Connor, M. J. and Bernard, H. U. (2000). Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA. J Virol 74(6): 2489-2501.
19. O'Connor, M. J., Stunkel, W., Koh, C. H., Zimmermann, H. and Bernard, H. U. (2000). The differentiation-specific factor CDP/Cut represses transcription and replication of human papillomaviruses through a conserved silencing element. J Virol 74(1): 401-410.
20. Stunkel, W. and Bernard, H. U. (1999). The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression. J Virol 73(3): 1918-1930.
21. O'Connor, M. J., Stunkel, W., Zimmermann, H., Koh, C. H. and Bernard, H. U. (1998). A novel YY1-independent silencer represses the activity of the human papillomavirus type 16 enhancer. J Virol 72(12): 10083-10092.
22. Spangenberg, C., Eisfeld, K., Stunkel, W., Luger, K., Flaus, A., Richmond, T. J., Truss, M. and Beato, M. (1998). The mouse mammary tumour virus promoter positioned on a tetramer of histones H3 and H4 binds nuclear factor 1 and OTF1. J Mol Biol 278(4): 725-739.
23. Stunkel, W., Kober, I. and Seifart, K. H. (1997). A nucleosome positioned in the distal promoter region activates transcription of the human U6 gene. Mol Cell Biol 17(8): 4397-4405.
24. Stunkel, W., Kober, I., Kauer, M., Taimor, G. and Seifart, K. H. (1995). Human TFIIIA alone is sufficient to prevent nucleosomal repression of a homologous 5S gene. Nucleic Acids Res 23(1): 109-116.
25. Ziegler, K. and Stunkel, W. (1992). Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter. Biochim Biophys Acta 1139(3): 203-209.