Gustavo Benaim
  • Professor, Instituto de Estudios Avanzados (IDEA)., Instituto de Estudios Avanzados (IDEA), Venezuela, 2002-2020; Head of Laboratoy of Biophysics, Instituto de Biologia Experimental. Faculty of Science, Universidad Central de Venezuela, Venezuela, 1992-2020; Head of Laboratory of Cell Signaling and Biochemistry of Parasites. , Instituto de Estudios Avanzados (IDEA). , Instituto de Estudios Avanzados (IDEA). , Venezuela, 2000-2020; Professor, Instituto de Estudios Avanzados (IDEA). , Instituto de Estudios Avanzados (IDEA). , Venezuela, 2000-2000
Research fields
  • Cell biology
Personal information

Education

PhD, "Doctor in Science" - Area: Cell Biology. Faculty of Science. Universidad Central de Venezuela and Instituto de Ciencias Biomedicas. Universidade Federal de Rio de aneiro. Brazil, 1988

Publications

Since 2015
• Stateva, S.R., Salas, V., Benaim, G., Menéndez, M., Solís, D. & Villalobo, A. (2015) Characterization of phospho-(tyrosine)-mimetic calmodulin mutants. PLoS One Apr 1;10(4):e0120798. doi: 10.1371/journal.pone.0120798. eCollection 2015.
• Paniz-Mondolfi, A., Rajesh S., Jour, G., Mahmoodi, M., Diwan, A.H., Barkoh, B.A., Cason, R., Huttenbach, Y., Benaim, G., Galbiacea, J. & Luthra, R. (2015) Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the question. (2015) Virchows Archiv. Eur. J. Pathol. 466: 359-60.
• Veiga-Santos, P., Li, K., Lameira, L., de Carvalho, T.M., Huang, G., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R.T., Urbina, J.A., Docampo, R., de Souza, W. & Oldfield, E. (2015) SQ109: A New Drug Lead for Chagas Disease. Antimicrob. Agents Chemother. 59: 50-61
• Stateva, S.R., Salas, V., Anguita, E., Benaim, G. & Villalobo, A. (2015) Ca2+/Camodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src. PLoS One June, 9 ;10 (6):e0128783. doi: 10.1371/journal.pone.0128783. eCollection 2015. PMID: 26058065
• Stateva, S.R., Salas, V., Benguría, A., Cossío, I., Anguita, E., Martín-Nieto, J., Benaim, G. & Villalobo, A. (2015).The Activating Role of Phospho-(Tyr)-Calmodulin on the Epidermal Growth Factor Receptor. Biochem. J. 472: 195-204
• Figarella, K., Marsiccobetre, S., Arocha, I., Colina, W., Hasegawa, M., Rodriguez, M., Duszenko, M., Benaim, G. & Uzcategui, N. L. (2016) Synthesis of Ergosterone-coupled Triazol and characterization of their biological activity on Leishmania mexicana promastigotes: Induction of mitochondrial dysfunction, oxidative stress, and acidocalcisomes Ca2+ release. Microbial Cell. 3: 14-28
• Sbaraglini, M.L., Vanrell, M.C., Bellera, C.L., Benaim, G., Carrillo, C., Talevi, A. & Romano, P.S. (2016). Drug repositioning for neglected tropical protozoan diseases. Curr. Top. Med. Chem. 16: 2201-2222
• Benaim, G., Pimentel, A.A., Felibertt, P., Mayora, A., Colman, L., Sojo, F., Rojas, H., & De Sanctis, J.B. (2016). Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity. Biochem. Biophys. Res. Commun. 473: 572-577
• García-García, V., Oldfield, E. & Benaim, G, (2016) Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109. Antimicrob. Agents Chemother. 60: 6386-6389
• Pérez-Gordones, M.C., Ramírez-Iglesias, J.R., Cervino, V., Uzcanga, G.L., Benaim, G., & Mendoza, M. (2017) Evidence of the presence of a calmodulin-sensitive plasma membrane Ca2+-ATPase in Trypanosoma equiperdum. Mol. Biochem. Parasitol. 213:1-11.
• De Gouveia Y., Hernández-Rodríguez V., Rodríguez-Durán J., Suárez A., & Benaim, G., (2017) Efecto de un metilen-dioxiflavonoide aislado de Iresine diffusa sobre la viabilidad celular de Leishmania mexicana y la homeostasis intracelular del Ca2+. Invest. Clín. 58: 334-351.
• Pinto-Martinez, A., Rodriguez-Durán, J., Serrano-Martin, X., Hernandez-Rodriguez, V. & Benaim, G. (2018) Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca2+ Channel. Antimicrob Agents Chemother. 62: 1-10
• Valdivieso, E., Torrealba, C., Mejias, F., Sojo, F., Rojas-Ruiz, F., Arvelo, F., Benaim, G., Kouznetsov, V & Dagger, V. (2018) In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption. Acta Tropíca 186: 36-42.
• Pinto-Martinez, A., Hernandez-Rodriguez, V.,Rodriguez-Duran, J. Hejchman, E. & Benaim, G. (2018) Anti-Trypanosoma cruzi action of a new benzofuran derivative based structure. Exp. Parasitol. 189: 8-15
• Ramírez-Iglesias, J.R., Pérez-Gordones, M.C. del Castillo, J.R. Mijares, A. Benaim, G. & Mendoza, M. (2018) Identification and characterization of a calmodulin binding domain in the plasma membrane Ca2+-ATPase from Trypanosoma equiperdum. Mol. Biochem. Parasitol. 222: 51-60
• Rodríguez, S., Silva, M., Benaím, G. & Bubis, J. (2018) Phosphorylation-Induced Conformational Changes of Photoactivated Rhodopsin Probed by Fluorescent Labeling at Cys140 and Cys316 Biochemie 150: 57-69
• Moghaddam, P.A., Singh, R., Mahmoodi, M., Mehrotra, M., Benaim, G., Luthra, R. & Paniz-Mondolfi, A. (2018) Poorly differentiated osteoclast-like giant cell variant of cutaneous squamous cell carcinoma: uncovering its mutational landscape through massive parallel sequencing. Pathol. Res. Pract. 214 : 1898-1903
• Grillet, M.E., Hernández, J.V., Llewellyn, M., Paniz-Mondolfi, A., Tami, A.,Vincenti, F., Marquez, M., Mogollon-Mendoza, A. Hernandez-Pereira, C., Plaza-Morr, J., Blohm, G., Grijalva, M., Costales, J.A., Fergusson, H., Schwabl, P., Castro, L.H., Lamberton, P., Streiker, D., Haydon, D., Miles, M.A., Segovia, M., Acosta-Serrano, A., Acquattelam H., Basáñez, M.G., Benaim, G., Conn, J.E., Freilij, H., Hotez, P., Kato, H., Lednicky, J., Mas-Coma, S., Morris, J.E., Navarro, J.C., Urbina, J.A., Villegas, L., Martinez, C.E., Rodríguez, M., Carrasco, H., Crainey, L., Luz, S., Moreno, J., Noya. O., Ramírez, J.D., Alarcón-de Noya, B. (2019) Venezuela’s humanitarian crisis, resurgence of vector-borne diseases and implications for spillover in the region: a call for action. Lancet Infect. Dis. 3099: 30757-30756.
• Martinez-Sotillo, N., Pinto-Martinez, A., Hejchman, E. & Benaim, G. (2019) Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis. Parasitol. Int. 70: 112-117
• Rodriguez-Duran, J., Pinto-Martinez, A., Castillo, C. & Benaim, G. (2019) Identification and Electrophysiological Properties of a Sphingosine-dependent Plasma Membrane Ca2+ Channel in Trypanosoma cruzi. FEBS J. 286: 3909-3925. doi: 10.1111/febs.14947
• Madigan, R., Majoy, S., Ritter, K., Concepción, J. L., Márquez, M. E., Silva, S. C., Zao, C. L., Pérez-Alvarez, A., Rodriguez-Morales, A., Mogollón-Mendoza, A. C.,Scot Estep, J., Benaím, G., & Paniz-Mondolfi, A.E. (2019) Successful treatment of canine Chagas’ Disease using combination treatment of Amiodarone and Itraconazole. J. Am. Vet. Med. Assoc. 255: 317-329
• Gil, Z., Martinez-Sotillo, N., Pinto-Martinez, A., Mejias, F., Martinez, J.C., Galindo-Castro, I., Oldfield, E. & Benaim, G. (2020) SQ109 inhibits proliferation of Leishmania donovani disruption of the intracellular Ca2+ homeostasis collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes. Parasitol. Res. 119: 649-65782
• Benaim, G., Paniz-Mondolfi, Sordillo, E.M. & Martinez-Sotillo, N. (2020) Disruption of intracellular calcium homeostasis as a therapeutic target against Trypanosoma cruzi. Review. Frontiers Cell. Infect. Microbiol.10: 46. doi: 10.3389/fcimb.2020.00046
• Benaim, G., Alberto Paniz-Mondolfi y Emilia Mia Sordillo (2020) Rationale for Use of Amiodarone and its Derivatives for Treatment of Chagas´ Disease and Leishmaniasis. Review. Curr. Pharmac. Design (in press)
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.