Namyr Martínez Department of Physiology and Biophysics, Medical Sciences Campus, University of Puerto Rico, Puerto Rico
1 protocol

Magdiel Martínez Department of Physiology and Biophysics, Medical Sciences Campus, University of Puerto Rico, Puerto Rico
1 protocol

Walter I. Silva
  • Department of Physiology and Biophysics, Medical Sciences Campus, University of Puerto Rico, Puerto Rico
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D, Pharmacology, Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York, 1986

Current position

Professor, Department of Physiology and Biophysics, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

Publications (since 2005)

  1. Martinez, N. A., Ayala, A. M., Martinez, M., Martinez-Rivera, F. J., Miranda, J. D. and Silva, W. I. (2016). Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J Biol Chem 291(23): 12208-12222.
  2. Delgado-Velez, M., Baez-Pagan, C. A., Gerena, Y., Quesada, O., Santiago-Perez, L. I., Capo-Velez, C. M., Wojna, V., Melendez, L., Leon-Rivera, R., Silva, W. and Lasalde-Dominicci, J. A. (2015). The alpha7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology 4(12): e53.
  3. Santiago, J. M., Torrado, A. I., Arocho, L. C., Rosas, O. R., Rodriguez, A. E., Toro, F. K., Salgado, I. K., Torres, Y. A., Silva, W. I. and Miranda, J. D. (2013). Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury. J Mol Neurosci 49(2): 347-359.
  4. Salgado, I. K., Serrano, M., Garcia, J. O., Martinez, N. A., Maldonado, H. M., Baez-Pagan, C. A., Lasalde-Dominicci, J. A. and Silva, W. I. (2012). SorLA in glia: shared subcellular distribution patterns with caveolin-1. Cell Mol Neurobiol 32(3): 409-421.
  5. Carlos A., B., Martínez-Ortiz, Y., Otero-Cruz, J. D., Salgado-Villanueva, I. K., Velázquez, G., Ortiz, A., Quezada, O., Silva, W. I. and Lasalde-Dominicci, J. A. (2008). Regulation of the functional pool of acetylcholine receptors via the interaction with caveolin-1-positive membrane microdomains. Channels 2(3): 180-190.
  6. Sanabria, P., Ross, E., Ramirez, E., Colon, K., Hernandez, M., Maldonado, H. M., Silva, W. I., Jimenez-Rivera, C. A. and Gonzalez, F. A. (2008). P2Y2 receptor desensitization on single endothelial cells. Endothelium 15(1): 43-51.
  7. Nieves-Cintron, M., Caballero-Rivera, D., Silva, W. I., Navedo, M. F. and Lasalde-Dominicci, J. A. (2008). Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor. J Neurosci Res 86(13): 2884-2894.
  8. Silva, W. I., Maldonado, H. M., Velazquez, G., Garcia, J. O. and Gonzalez, F. A. (2007). Caveolins in glial cell model systems: from detection to significance. J Neurochem 103 Suppl 1: 101-112.
  9. Kao, W. H., Silva, W. I. and Sanchez, N. P. (2006). Caveolae in Human Disease- A dermatologic Perspective. Caribbean Journal of Dermatology and Therapeutics 3:13-18.
  10. Rubio-Dávila, M., Berríos, Maldonado, P. M., Feliciano, M., Ramos, I., Rassi, N., Silva, W. I., Jiménez-Rivera, C. A. and Ortiz, J. G. (2006). Changes In AMPA and NMDA Receptor Binding To Cortical Membrane Fractions Cocaine-Treated Rats. Annals NY Academy of Sciences 1074: 403-410.
  11. Silva, W. I., Maldonado, H. M., Velazquez, G., Rubio-Davila, M., Miranda, J. D., Aquino, E., Mayol, N., Cruz-Torres, A., Jardon, J. and Salgado-Villanueva, I. K. (2005). Caveolin isoform expression during differentiation of C6 glioma cells. Int J Dev Neurosci 23(7): 599-612.
1 Protocol published
Measurement of the Intracellular Calcium Concentration with Fura-2 AM Using a Fluorescence Plate Reader
Authors:  Magdiel Martínez, Namyr A. Martínez and Walter I. Silva, date: 07/20/2017, view: 29115, Q&A: 1
Intracellular calcium elevation triggers a wide range of cellular responses. Calcium responses can be affected or modulated by membrane receptors mutations, localization, exposure to agonists/antagonists, among others (Burgos et al., 2007; ...
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