Célia Maria Soares Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Brazil
1 protocol

Mirelle Silva-Bailão Universidade Federal de Goiás, Unidade Acadêmica Especial Ciências da Saúde, Brazil
1 protocol

Elisa Flávia Bailão Universidade Estadual de Goiás, Câmpus Henrique Santillo, Brazil
1 protocol

Daniel J. Kosman
  • Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Research focus
  • Microbiology
  • 1 Author merit


Ph.D. in Physical Organic Chemistry, University of Chicago, 1968

Current position

SUNY Distinguished Professor, Biochemistry, Jacobs School of Medicine and Biomedical Sciences

Publications (since 2011)

  1. Bailao, E. F., Lima Pde, S., Silva-Bailao, M. G., Bailao, A. M., Fernandes Gda, R., Kosman, D. J. and Soares, C. M. (2015). Paracoccidioides spp. ferrous and ferric iron assimilation pathways. Front Microbiol 6: 821.

  2. Ji, C. and Kosman, D. J. (2015). Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J Neurochem 133(5): 668-683.

  3. McCarthy, R. C. and Kosman, D. J. (2015). Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front Mol Neurosci 8: 31.

  4. McCarthy, R. C. and Kosman, D. J. (2015). Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy. Cell Mol Life Sci 72(4): 709-727.

  5. McCarthy, R. C., Park, Y. H. and Kosman, D. J. (2014). sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 15(7): 809-815.

  6. McCarthy, R. C. and Kosman, D. J. (2014). Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system. Cell Commun Signal 12: 65.

  7. McCarthy, R. C. and Kosman, D. J. (2014). Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS One 9(2): e89003.

  8. Kjaergaard, C. H., Qayyum, M. F., Augustine, A. J., Ziegler, L., Kosman, D. J., Hodgson, K. O., Hedman, B. and Solomon, E. I. (2013). Modified reactivity toward O2 in first shell variants of Fet3p: geometric and electronic structure requirements for a functioning trinuclear copper cluster. Biochemistry 52(21): 3702-3711.

  9. McCarthy, R. C. and Kosman, D. J. (2013). Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux. J Biol Chem 288(24): 17932-17940.

  10. Kosman, D. J. (2013). Iron metabolism in aerobes: managing ferric iron hydrolysis and ferrous iron autoxidation. Coord Chem Rev 257(1): 210-217.

  11. McCarthy, R. C. and Kosman, D. J. (2012). Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals 25(4): 665-675.

  12. Kosman, D. J. (2011). Transport: Plutonium's Trojan horse. Nat Chem Biol 7(8): 498-499.

  13. Ziegler, L., Terzulli, A., Gaur, R., McCarthy, R. and Kosman, D. J. (2011). Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans. Mol Microbiol 81(2): 473-485.

1 Protocol published
59Fe Uptake Assays in Paracoccidioides Species
Iron is an essential micronutrient required for virtually all organisms. This fact is related to the ability of the transition metal to exist in two oxidation states, the reduced ferrous (Fe2+) and the oxidized ferric (Fe3+). ...
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