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Study design, inclusion and exclusion criteria.

RP Riccardo Pofi
EG Elisa Giannetta
DG Daniele Gianfrilli
AI Andrea M. Isidori

Last updated date: Jun 29, 2022 Views: 544 Forks: 0

original An abbreviated version of this protocol was published in Science Translational Medicine in Jun, 2022
Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial
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Please find attached the detailed protocol with all the informations needed.
As clearly mentioned in the manuscript, Diabetic Cardiomyopathy is diagnosed with Cardiac magnetic resonance (CMR) characteristics: thickened interventricular septum, increased cardiac torsion (normal value between 10° and 15°) and reduced cardiac strain (normal value ≤14%).

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pdf Study-Protocol_RECOGITO_v1.2.pdf download
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How to cite：
Readers should cite both the Bio-protocol preprint and the original research article where this protocol was used:
  1. Pofi, R, Giannetta, E, Gianfrilli, D and Isidori, A(2022). Study design, inclusion and exclusion criteria.. Bio-protocol Preprint. bio-protocol.org/prep1756.
  2. Pofi, R., Giannetta, E., Feola, T., Galea, N., Barbagallo, F., Campolo, F., Badagliacca, R., Barbano, B., Ciolina, F., Defeudis, G., Filardi, T., Sesti, F., Minnetti, M., Vizza, C. D., Pasqualetti, P., Caboni, P., Carbone, I., Francone, M., Catalano, C., Pozzilli, P., Lenzi, A., Venneri, M. A., Gianfrilli, D. and Isidori, A. M.(2022). Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial. Science Translational Medicine 14(649). DOI: 10.1126/scitranslmed.abl8503

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