Did LR-ExM will be helpful in analyzing aptamer tagged gene based drug effect in biological systems and it's proteomics changes?

1) In a study for Gene based drug action in cells or rodents, can we check changes occurring at the molecular level through LR-EXm?

2) whether it is compulsory to have drug fluorescent leveled or not for detection?

3) Can we do kinetics study using LR-EXm?