Mouse treatments

Title Ketogenic diet uncovers differential metabolic plasticity of brain cells

Author information

Tim Düking,¹† Lena Spieth,¹† Stefan A. Berghoff,¹†‡ Lars Piepkorn,^2,3 Annika M. Schmidke,¹ Miso Mitkovski,⁴ Nirmal Kannaiyan,⁵ Leon Hosang,⁶ Patricia Scholz,⁷ Ali H. Shaib,^8,9 Lennart V. Schneider,¹§ Dörte Hesse,^1,2 Torben Ruhwedel,^1,10 Ting Sun,¹ Lisa Linhoff,^11,12 Andrea Trevisiol,¹|| Susanne Köhler,¹⁵ Adrian Marti Pastor,¹⁶ Thomas Misgeld,¹⁶ Michael Sereda,^11,12 Imam Hassouna,¹ Moritz J. Rossner,⁵ Francesca Odoardi,⁶ Till Ischebeck,^7,13 Livia de Hoz,^1,14 Johannes Hirrlinger,^1,15 Olaf Jahn,^2,3 and Gesine Saher¹*

¹ Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen

² Neuroproteomics Group, Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen

³ Translational Neuroproteomics Group, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany

⁴ City Campus Light Microscopy Facility, Max Planck Institute for Multidisciplinary Sciences, Göttingen ⁵ Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany

⁶ Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, Göttingen, Germany

⁷ Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences and Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany

⁸ Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen

⁹ Institute for Neuro- and Sensory Physiology, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany

¹⁰ Electron Microscopy Core Unit, Max Planck Institute for Multidisciplinary Sciences, Göttingen

¹¹ Department of Neurology, University Medical Center Göttingen, Göttingen, Germany

¹² Translational Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen

¹³ University of Münster, Institute of Plant Biology and Biotechnology (IBBP), Green Biotechnology, Münster, Germany

¹⁴ Neurowissenschafliches Forschungszentrum, Charité - Universitätsmedizin Berlin, Germany

¹⁵ Carl-Ludwig-Institute for Physiology, Medical Faculty, University of Leipzig, Leipzig, Germany

¹⁶ Institute of Neuronal Cell Biology, Technische Universität München, Munich Cluster for Systems Neurology (SyNergy), German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

Materials and reagents

Please find attached the formulation of the ketogenic diet that we used in Düking et al. "Ketogenic diet uncovers differential metabolic plasticity of brain cells" via Science Advances 8, eabo7639 (2022).