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Lentiviral Knockdown of Transcription Factor STAT1 in
Peromyscus leucopus
to Assess Its Role in the Restriction of Tick-borne Flaviviruses
Authors:
Adaeze O. Izuogu
and
R. Travis Taylor
,
date:
12/05/2017,
view:
8556,
Q&A:
0
[Abstract] Cellular infection with tick-borne flaviviruses (TBFVs) results in activation of the interferon (IFN) signaling pathway and subsequent upregulation of numerous genes termed IFN stimulated genes (ISGs) (Schoggins
et al.
, 2011). Many ISGs function to prevent virus pathogenesis by acting in a broad or specific manner through protein-protein ...
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