Contusion Spinal Cord Injury Rat Model
Authors: Chuan-Wen Chiu,
Henrich Cheng and
Shie-Liang Hsieh,
date: 06/20/2017,
view: 10091,
Q&A: 0
[Abstract] Spinal cord injury (SCI) can lead to severe disability, paralysis, neurological deficits and even death. In humans, most spinal cord injuries are caused by transient compression or contusion of the spinal cord associated with motor vehicle accidents. Animal models of contusion mimic the typical SCI’s found in humans and these models are key to the ...
Peripheral Nerve Injury: a Mouse Model of Neuropathic Pain
[Abstract] Neuropathic pain is one of the highly debilitating chronic pain conditions, for which, currently, there is no therapeutic treatment. In order to reveal the underlying mechanism for neuropathic pain, various animal models have been established (Burma et al., 2016). This protocol describes how to prepare spinal nerve injury model (Kim and ...
In vitro Brainstem-spinal Cord Preparation from Newborn Rat
[Abstract] The brainstem-spinal cord preparation of newborn rat contains neural networks able to produce motor output in absence of sensory feedback. These neural structures, commonly called central pattern generators (CPGs), are involved in many vital functions such as respiration (Morin and Viala, 2002; Giraudin et al., 2008) or locomotion (Juvin ...
Mitochondrial Isolation and Purification from Mouse Spinal Cord
[Abstract] Mitochondria are eukaryotic organelles that play a crucial role in several cellular processes, including energy production, β-oxidation of fatty acids and regulation of calcium homeostasis. In the last 20 years there has been a hightened interest in the study of mitochondria following the discoveries that mitochondria are central to the process of ...
Rat Model of Chronic Midthoracic Lateral Hemisection
Author: Victor Arvanian,
date: 09/20/2013,
view: 9960,
Q&A: 0
[Abstract] Although most spinal cord injuries (SCI) are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions. To address why surviving fibers cannot mediate more complete recovery, it is important to evaluate the physiological and anatomical status of spared fibers. These experiments require use ...
Generation of Mouse Spinal Cord Injury
[Abstract] Spinal cord injury (SCI) is a debilitating injury with significant morbidity and mortalitiy. Understanding the pathogensis of and developing treatments for SCI requires robust animal models. Here we describe a method for generating an efficient and reproducible contusion model of SCI in adult mice.