Cancer Biology

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    Protocols in Current Issue
    Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines
    Authors:  Elza C. de Bruin, Ming Jiang, Michael Howell and Julian Downward, date: 05/20/2015, view: 11523, Q&A: 0
    [Abstract] The expression of genes is frequently manipulated in cell lines to study their cellular functions. The use of exogenous small Interfering RNAs (siRNAs) is a very efficient technique to temporarily downregulate the expression of genes of interest [reviewed by Hannon and Rossi (2004)]. A genome-wide siRNA library allows the user to study both the ...



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