Mammalia

Categories

    Protocols in Current Issue
    Non-separate Mouse Sclerochoroid/RPE/Retina Staining and Whole Mount for the Integral Observation of Subretinal Layer
    Authors:  Sung-Jin Lee and Soo-Young Kim, date: 01/05/2021, view: 1676, Q&A: 0
    [Abstract]

    The subretinal layer between retinal pigment epithelium (RPE) and photoreceptors is a region involved in inflammation and angiogenesis during the procession of diseases such as age-related macular degeneration. The current protocols of whole mounts (retina and RPE) are unable to address the intact view of the subretinal layer because the

    ...
    Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration
    [Abstract] In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive or regenerate their optic nerve axons underlies partial and, in some cases, complete vision loss. Optic nerve crush (ONC) serves as a useful model not only of traumatic optic neuropathy but also of glaucomatous injury, as it similarly induces RGC cell death ...
    Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System
    Authors:  Carole A Bartlett and Melinda Fitzgerald, date: 12/20/2018, view: 3352, Q&A: 0
    [Abstract] Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal ...
    Embryonic Intravitreous Injection in Mouse
    Authors:  Liyuan Cui, Yupu Diao and Jiayi Zhang, date: 07/20/2018, view: 4067, Q&A: 0
    [Abstract] Axons of retinal ganglion cells (RGCs) relay visual information from the retina to lateral geniculate nucleus (LGN) and superior colliculus (SC), which are two major image-forming visual nuclei. Wiring of these retinal projections completes before vision begins. However, there are few studies on retinal axons at embryonic stage due to technical ...



    We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.