Education

Ph.D., École polytechnique fédérale de Lausanne, 2010

Lab information

Adolfo A Ferrando, Columbia University, New York, NY, USA

Research focus

The Ferrando Laboratory is endeavoring to understand the molecular mechanisms that promote and sustain the malignant proliferation and survival of leukemic cells.

Publications

http://ferrandolab.org/publications.html

• Belver, L., Yang, A. Y., Albero, R., Herranz, D., Brundu, F. G., Quinn, S. A., Perez-Duran, P., Alvarez, S., Gianni, F., Rashkovan, M., Gurung, D., Rocha, P. P., Raviram, R., Reglero, C., Cortes, J. R., Cooke, A. J., Wendorff, A. A., Cordo, V., Meijerink, J. P., Rabadan, R. and Ferrando, A. A. (2019). GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. Cancer Discov 9(12): 1774-1791.
• Wendorff, A. A., Quinn, S. A., Rashkovan, M., Madubata, C. J., Ambesi-Impiombato, A., Litzow, M. R., Tallman, M. S., Paietta, E., Paganin, M., Basso, G., Gastier-Foster, J. M., Loh, M. L., Rabadan, R., Van Vlierberghe, P. and Ferrando, A. A. (2019). Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. Cancer Discov 9(3): 436-451.
• Herranz, D., Ambesi-Impiombato, A., Sudderth, J., Sanchez-Martin, M., Belver, L., Tosello, V., Xu, L., Wendorff, A. A., Castillo, M., Haydu, J. E., Marquez, J., Mates, J. M., Kung, A. L., Rayport, S., Cordon-Cardo, C., DeBerardinis, R. J. and Ferrando, A. A. (2015). Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med 21(10): 1182-1189.
• Herranz, D., Ambesi-Impiombato, A., Palomero, T., Schnell, S. A., Belver, L., Wendorff, A. A., Xu, L., Castillo-Martin, M., Llobet-Navas, D., Cordon-Cardo, C., Clappier, E., Soulier, J. and Ferrando, A. A. (2014). A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med 20(10): 1130-1137.
• Wendorff, A. A., Koch, U., Wunderlich, F. T., Wirth, S., Dubey, C., Bruning, J. C., MacDonald, H. R. and Radtke, F. (2010). Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33(5): 671-684.