Education

PhD in Immunology, University of Toulouse, France, 1992

Current position

Senior researcher at CNRS, Team of JP Girard, Institute of Pharmacology and Structural Biology (IPBS-CNRS), University of Toulouse, France

Publications

1. Cayrol, C. and Girard, J. P. (2018). Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev 281(1): 154-168. 

2. Cayrol, C., Duval, A., Schmitt, P., Roga, S., Camus, M., Stella, A., Burlet-Schiltz, O., Gonzalez-de-Peredo, A. and Girard, J.-P. (2018). Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nature Immunology 19(4): 375-385. 

3. Gautier, V., Cayrol, C., Farache, D., Roga, S., Monsarrat, B., Burlet-Schiltz, O., Gonzalez de Peredo, A. and Girard, J. P. (2016). Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells. Sci Rep 6: 34255. 

4. Lefrancais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C. and Girard, J. P. (2014). Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A 111(43): 15502-15507. 

5. Cayrol, C. and Girard, J. P. (2014). IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol 31: 31-37. 

6. Lefrancais, E., Roga, S., Gautier, V., Gonzalez-de-Peredo, A., Monsarrat, B., Girard, J. P. and Cayrol, C. (2012). IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A 109(5): 1673-1678. 

7. Cayrol, C. and Girard, J. P. (2009). The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106(22): 9021-9026. 

8. Roussel, L., Erard, M., Cayrol, C. and Girard, J. P. (2008). Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep 9(10): 1006-1012.