Education

Ph.D., University of Cincinnati College of Medicine, United States

Current position

Associate Member (Associate Professor), Cell and Molecular Biology, St. Jude Children's Research Hospital, United States

Publications

1. Stewart, D. P., Marada, S., Bodeen, W. J., Truong, A., Sakurada, S. M., Pandit, T., Pruett-Miller, S. M. and Ogden, S. K. (2018). Cleavage activates dispatched for Sonic Hedgehog ligand release. Elife 7.
2. Bodeen, W. J., Marada, S., Truong, A. and Ogden, S. K. (2017). A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport. Development 144(19): 3612-3624.
   
3. Arensdorf, A. M., Dillard, M. E., Menke, J. M., Frank, M. W., Rock, C. O. and Ogden, S. K. (2017). Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation. Cell Rep 19(10): 2074-2087.
   
4. Marzahn, M. R., Marada, S., Lee, J., Nourse, A., Kenrick, S., Zhao, H., Ben-Nissan, G., Kolaitis, R. M., Peters, J. L., Pounds, S., Errington, W. J., Prive, G. G., Taylor, J. P., Sharon, M., Schuck, P., Ogden, S. K. and Mittag, T. (2016). Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. EMBO J 35(12): 1254-1275.
   
5. Marada, S., Truong, A. and Ogden, S. K. (2016). Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog. Data Brief 7: 485-489.
   
6. Marada, S., Truong, A. and Ogden, S. K. (2016). The small GTPase Rap1 is a modulator of Hedgehog signaling. Dev Biol 409(1): 84-94.
   
7. Marada, S., Navarro, G., Truong, A., Stewart, D. P., Arensdorf, A. M., Nachtergaele, S., Angelats, E., Opferman, J. T., Rohatgi, R., McCormick, P. J. and Ogden, S. K. (2015). Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLoS Genet 11(8): e1005473.
   
8. Rana, R., Carroll, C. E., Lee, H. J., Bao, J., Marada, S., Grace, C. R., Guibao, C. D., Ogden, S. K. and Zheng, J. J. (2013). Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. Nat Commun 4: 2965.
   
9. Marada, S., Stewart, D. P., Bodeen, W. J., Han, Y. G. and Ogden, S. K. (2013). The unfolded protein response selectively targets active smoothened mutants. Mol Cell Biol 33(12): 2375-2387.
   
10. Gruber, T. A., Larson Gedman, A., Zhang, J., Koss, C. S., Marada, S., Ta, H. Q., Chen, S. C., Su, X., Ogden, S. K., Dang, J., Wu, G., Gupta, V., Andersson, A. K., Pounds, S., Shi, L., Easton, J., Barbato, M. I., Mulder, H. L., Manne, J., Wang, J., Rusch, M., Ranade, S., Ganti, R., Parker, M., Ma, J., Radtke, I., Ding, L., Cazzaniga, G., Biondi, A., Kornblau, S. M., Ravandi, F., Kantarjian, H., Nimer, S. D., Dohner, K., Dohner, H., Ley, T. J., Ballerini, P., Shurtleff, S., Tomizawa, D., Adachi, S., Hayashi, Y., Tawa, A., Shih, L. Y., Liang, D. C., Rubnitz, J. E., Pui, C. H., Mardis, E. R., Wilson, R. K. and Downing, J. R. (2012). An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell 22(5): 683-697.
    
11. Carroll, C. E., Marada, S., Stewart, D. P., Ouyang, J. X. and Ogden, S. K.  (2012). The extracellular loops of Smoothened play regulatory roles in control of Hedgehog signal transduction. Development 139, 612-621
    
12. Farzan, S. F., Ogden, S. K. and Robbins D. J. (2010). Quantitative insight into models of Hedgehog signal transduction. Fly 4, (2), 141-144.
    
13. Farzan, S. F., Stegman, M. A., Ogden, S. K., Ascano, M., Jr., Black, K. E., Tacchelly, O. and Robbins, D. J. (2009). A quantification of pathway components supports a novel model of Hedgehog signal transduction. J Biol Chem 284(42): 28874-28884.
    
14. Ogden, S. K., Fei, D. L., Schilling, N. S., Ahmed, Y. F., Hwa, J. and Robbins, D. J. (2008). G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature 456(7224): 967-970.
    
15. Farzan, S. F., Ascano, M., Jr., Ogden, S. K., Sanial, M., Brigui, A., Plessis, A. and Robbins, D. J. (2008). Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr Biol 18(16): 1215-1220.
    
16. Casso, D. J., Liu, S., Iwaki, D. D., Ogden, S. K. and Kornberg, T. B. (2008). A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics 178(3): 1399-1413.
    
17. Yuan, Z., Goetz, J. A., Singh, S., Ogden, S. K., Petty, W. J., Black, C. C., Memoli, V. A., Dmitrovsky, E. and Robbins, D. J. (2007). Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene 26(7): 1046-1055.
    
18. Ogden, S. K., Casso, D. J., Ascano, M., Jr., Yore, M. M., Kornberg, T. B. and Robbins, D. J. (2006). Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem 281(11): 7237-7243.
    
19. Wilkinson, D. S., Ogden, S. K., Stratton, S. A., Piechan, J. L., Nguyen, T. T., Smulian, G. A. and Barton, M. C. (2005). A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25(3): 1200-1212.
    
20. Stegman, M. A., Goetz, J. A., Ascano, M., Jr., Ogden, S. K., Nybakken, K. E. and Robbins, D. J. (2004). The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. J Biol Chem 279(8): 7064-7071.
    
21. Ogden, S. K., Ascano, M., Jr., Stegman, M. A., Suber, L. M., Hooper, J. E. and Robbins, D. J. (2003). Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol 13(22): 1998-2003.
    
22. Ogden, S. K., Lee, K. C., Wernke-Dollries, K., Stratton, S. A., Aronow, B. and Barton, M. C. (2001). p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression. J Biol Chem 276(45): 42057-42062.
    
23. Ogden, S. K., Lee, K. C. and Barton, M. C. (2000). Hepatitis B viral transactivator HBx alleviates p53-mediated repression of alpha-fetoprotein gene expression. J Biol Chem 275(36): 27806-27814.