Education
PhD, University of Crete, Greece, 2006
Current position
Group Leader, Diabetes Research Institute, San Raffaele Scientific Institute, Italy
Publications
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Sebastiani, G., Ventriglia, G., Stabilini, A., Socci, C., Morsiani, C., Laurenzi, A., Nigi, L., Formichi, C., Mfarrej, B., Petrelli, A., Fousteri, G., Brusko, T. M., Dotta, F. and Battaglia, M. (2017). Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression. Sci Rep 7(1): 6897.
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Jofra, T., Galvani, G., Kuka, M., Di Fonte, R., Mfarrej, B. G., Iannacone, M., Salek-Ardakani, S., Battaglia, M. and Fousteri, G. (2017). Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. Front Immunol 8: 811.
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Jofra, T., Di Fonte, R., Hutchinson, T. E., Dastmalchi, F., Galvani, G., Battaglia, M., Salek-Ardakani, S. and Fousteri, G. (2017). Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses. Immunol Cell Biol 95(2): 121-128.
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Gerosa, J., Lougaris, V., Baronio, M., Plebani, A., Cicalese, M. P. and Fousteri, G. (2017). Beta2 integrins are required for follicular helper T cell differentiation in humans. Clin Immunol 180: 60-62.
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Galvani, G. and Fousteri, G. (2017). PTPN22 and islet-specific autoimmunity: What have the mouse models taught us? World J Diabetes 8(7): 330-336.
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Fousteri, G., Ippolito, E., Ahmed, R. and Hamad, A. R. A. (2017). Beta-cell Specific Autoantibodies: Are they Just an Indicator of Type 1 Diabetes? Curr Diabetes Rev 13(3): 322-329.
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Cantarelli, E., Citro, A., Pellegrini, S., Mercalli, A., Melzi, R., Dugnani, E., Jofra, T., Fousteri, G., Mondino, A. and Piemonti, L. (2017). Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow Versus Liver. Transplantation 101(5): 1046-1055.
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Hamad, A. R., Ahmed, R., Donner, T. and Fousteri, G. (2016). B cell-targeted immunotherapy for type 1 diabetes: What can make it work? Discov Med 21(115): 213-219.
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Di Fonte, R., Baronio, M., Plebani, A., Lougaris, V. and Fousteri, G. (2016). Reduced germinal center follicular helper T cells but normal follicular regulatory T cells in the tonsils of a patient with a mutation in the PI3KR1 gene. Clin Immunol 164: 43-44.
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Fousteri, G., Jofra, T., Di Fonte, R., Kuka, M., Iannacone, M. and Battaglia, M. (2015). PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Clin Immunol 156(2): 98-108.
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Fousteri, G., Jofra, T., Di Fonte, R., Gagliani, N., Morsiani, C., Stabilini, A. and Battaglia, M. (2015). Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice. Diabetologia 58(6): 1319-1328.
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Fousteri, G., Jofra, T., Di Fonte, R. and Battaglia, M. (2015). Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice. PLoS One 10(6): e0127631.
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Sarikonda, G., Fousteri, G., Sachithanantham, S., Miller, J. F., Dave, A., Juntti, T., Coppieters, K. T. and von Herrath, M. (2014). BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells. PLoS One 9(11): e112242.
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Jones, C. B., Pagni, P. P., Fousteri, G., Sachithanantham, S., Dave, A., Rodriguez-Calvo, T., Miller, J. and von Herrath, M. (2014). Regulatory T cells control diabetes without compromising acute anti-viral defense. Clin Immunol 153(2): 298-307.
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Fousteri, G., Jofra, T., Debernardis, I., Stanford, S. M., Laurenzi, A., Bottini, N. and Battaglia, M. (2014). The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clin Exp Immunol 178(1): 178-189.
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Passerini, L., Rossi Mel, E., Sartirana, C., Fousteri, G., Bondanza, A., Naldini, L., Roncarolo, M. G. and Bacchetta, R. (2013). CD4(+) T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer. Sci Transl Med 5(215): 215ra174.
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Fousteri, G., Liossis, S. N. and Battaglia, M. (2013). Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity. Clin Immunol 149(3): 556-565.
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Fousteri, G., Jasinski, J., Dave, A., Nakayama, M., Pagni, P., Lambolez, F., Juntti, T., Sarikonda, G., Cheng, Y., Croft, M., Cheroutre, H., Eisenbarth, G. and von Herrath, M. (2012). Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes 61(5): 1169-1179.
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Andolfi, G., Fousteri, G., Rossetti, M., Magnani, C. F., Jofra, T., Locafaro, G., Bondanza, A., Gregori, S. and Roncarolo, M. G. (2012). Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells. Mol Ther 20(9): 1778-1790.
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Fousteri, G., Dave, A., Morin, B., Omid, S., Croft, M. and von Herrath, M. G. (2011). Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. J Autoimmun 36(3-4): 210-220.
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Fousteri, G., Dave, A., Juedes, A., Juntti, T., Morin, B., Togher, L., Farber, D. L. and von Herrath, M. (2011). Increased memory conversion of naive CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure. PLoS One 6(1): e14502.
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Bresson, D., Fousteri, G., Manenkova, Y., Croft, M. and von Herrath, M. (2011). Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37(4): 342-351.
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Fousteri, G., Dave, A., Juntti, T., Morin, B., McClure, M. and Von Herrath, M. (2010). Minimal effect of CD103 expression on the control of a chronic antiviral immune response. Viral Immunol 23(3): 285-294.
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Fousteri, G., Dave, A., Bot, A., Juntti, T., Omid, S. and von Herrath, M. (2010). Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia 53(9): 1958-1970.
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Fousteri, G., Chan, J. R., Zheng, Y., Whiting, C., Dave, A., Bresson, D., Croft, M. and von Herrath, M. (2010). Virtual optimization of nasal insulin therapy predicts immunization frequency to be crucial for diabetes protection. Diabetes 59(12): 3148-3158.
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Fousteri, G., Dave, A., Juntti, T. and von Herrath, M. (2009). CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes. J Autoimmun 32(1): 70-77.
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Fousteri, M. and Mullenders, L. H. (2008). Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res 18(1): 73-84.
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Fousteri, G. and von Herrath, M. (2008). First-trimester human fetal pancreas transplantation for type 1 diabetes treatment: an alternative approach for achieving long-term graft survival? Diabetes 57(3): 525-526.
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Fousteri, G., von Herrath, M. and Bresson, D. (2007). Mucosal exposure to antigen: cause or cure of type 1 diabetes? Curr Diab Rep 7(2): 91-98.
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Fousteri, G., Hayek, A. and von Herrath, M. (2007). Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation. Regen Med 2(5): 845-851.
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Fousteri, G., Bresson, D. and von Herrath, M. (2007). Rational development of antigen-specific therapies for type 1 diabetes. Adv Exp Med Biol 601: 313-319.
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Chatzidakis, I., Fousteri, G., Tsoukatou, D., Kollias, G. and Mamalaki, C. (2007). An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells. J Immunol 178(11): 6735-6745.