Education

PhD in Biology, University of Murcia, Spain

Current position

Professor, Department of Genetics and Microbiology, University of Murcia, Spain

Publications

1. Silas, S., Lucas-Elio, P., Jackson, S. A., Aroca-Crevillen, A., Hansen, L. L., Fineran, P. C., Fire, A. Z. and Sanchez-Amat, A. (2017). Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems. Elife 6.
2. Williamson, H. R., Sehanobish, E., Shiller, A. M., Sanchez-Amat, A. and Davidson, V. L. (2017). Roles of Copper and a Conserved Aspartic Acid in the Autocatalytic Hydroxylation of a Specific Tryptophan Residue during Cysteine Tryptophylquinone Biogenesis. Biochemistry 56(7): 997-1004.
3. Silas, S., Mohr, G., Sidote, D. J., Markham, L. M., Sanchez-Amat, A., Bhaya, D., Lambowitz, A. M. and Fire, A. Z. (2016). Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase-Cas1 fusion protein. Science 351(6276): aad4234.
4. Sehanobish, E., Campillo-Brocal, J. C., Williamson, H. R., Sanchez-Amat, A. and Davidson, V. L. (2016). Interaction of GoxA with Its Modifying Enzyme and Its Subunit Assembly Are Dependent on the Extent of Cysteine Tryptophylquinone Biosynthesis. Biochemistry 55(16): 2305-2308.
5. Tonin, F., Melis, R., Cordes, A., Sanchez-Amat, A., Pollegioni, L. and Rosini, E. (2016). Comparison of different microbial laccases as tools for industrial uses. N Biotechnol 33(3): 387-398.
6. Tonin, F., Rosini, E., Piubelli, L., Sanchez-Amat, A. and Pollegioni, L. (2016). Different recombinant forms of polyphenol oxidase A, a laccase from Marinomonas mediterranea. Protein Expr Purif 123: 60-69.
7. Campillo-Brocal, J. C., Chacon-Verdu, M. D., Lucas-Elio, P. and Sanchez-Amat, A. (2015). Distribution in microbial genomes of genes similar to lodA and goxA which encode a novel family of quinoproteins with amino acid oxidase activity. BMC Genomics 16: 231.
8. Campillo-Brocal, J. C., Lucas-Elio, P. and Sanchez-Amat, A. (2015). Distribution in Different Organisms of Amino Acid Oxidases with FAD or a Quinone As Cofactor and Their Role as Antimicrobial Proteins in Marine Bacteria. Mar Drugs 13(12): 7403-7418.
9. Chacon-Verdu, M. D., Campillo-Brocal, J. C., Lucas-Elio, P., Davidson, V. L. and Sanchez-Amat, A. (2015). Characterization of recombinant biosynthetic precursors of the cysteine tryptophylquinone cofactors of l-lysine-epsilon-oxidase and glycine oxidase from Marinomonas mediterranea. Biochim Biophys Acta 1854(9): 1123-1131.
10. Sehanobish, E., Chacon-Verdu, M. D., Sanchez-Amat, A. and Davidson, V. L. (2015). Roles of active site residues in LodA, a cysteine tryptophylquinone dependent epsilon-lysine oxidase. Arch Biochem Biophys 579: 26-32.
11. Sehanobish, E., Shin, S., Sanchez-Amat, A. and Davidson, V. L. (2014). Steady-state kinetic mechanism of LodA, a novel cysteine tryptophylquinone-dependent oxidase. FEBS Lett 588(5): 752-756.
12. Chacon-Verdu, M. D., Gomez, D., Solano, F., Lucas-Elio, P. and Sanchez-Amat, A. (2014). LodB is required for the recombinant synthesis of the quinoprotein L-lysine-epsilon-oxidase from Marinomonas mediterranea. Appl Microbiol Biotechnol 98(7): 2981-2989.
13. Campillo-Brocal, J. C., Lucas-Elio, P. and Sanchez-Amat, A. (2013). Identification in Marinomonas mediterranea of a novel quinoprotein with glycine oxidase activity. Microbiologyopen 2(4): 684-694.
14. Bengtsson, M. M., Buhler, A., Brauer, A., Dahlke, S., Schubert, H. and Blindow, I. (2017). Eelgrass Leaf Surface Microbiomes Are Locally Variable and Highly Correlated with Epibiotic Eukaryotes. Front Microbiol 8: 1312.
15. Lucas-Elio, P., Goodwin, L., Woyke, T., Pitluck, S., Nolan, M., Kyrpides, N. C., Detter, J. C., Copeland, A., Lu, M., Bruce, D., Detter, C., Tapia, R., Han, S., Land, M. L., Ivanova, N., Mikhailova, N., Johnston, A. W. and Sanchez-Amat, A. (2012). Complete genome sequence of Marinomonas posidonica type strain (IVIA-Po-181(T)). Stand Genomic Sci 7(1): 31-43.
16. Lucas-Elio, P., Goodwin, L., Woyke, T., Pitluck, S., Nolan, M., Kyrpides, N. C., Detter, J. C., Copeland, A., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Land, M. L., Ivanova, N., Mikhailova, N., Johnston, A. W. and Sanchez-Amat, A. (2012). Complete genome sequence of the melanogenic marine bacterium Marinomonas mediterranea type strain (MMB-1(T)). Stand Genomic Sci 6(1): 63-73.
17. Lucas-Elio, P., Marco-Noales, E., Espinosa, E., Ordax, M., Lopez, M. M., Garcias-Bonet, N., Marba, N., Duarte, C. M. and Sanchez-Amat, A. (2011). Marinomonas alcarazii sp. nov., M. rhizomae sp. nov., M. foliarum sp. nov., M. posidonica sp. nov. and M. aquiplantarum sp. nov., isolated from the microbiota of the seagrass Posidonia oceanica. Int J Syst Evol Microbiol 61(Pt 9): 2191-2196.
18. Galai, S., Lucas-Elio, P., Marzouki, M. N. and Sanchez-Amat, A. (2011). Molecular cloning of a copper-dependent laccase from the dye-decolorizing strain Stenotrophomonas maltophilia AAP56. J Appl Microbiol 111(6): 1394-1405.
19. Espinosa, E., Marco-Noales, E., Gomez, D., Lucas-Elio, P., Ordax, M., Garcias-Bonet, N., Duarte, C. M. and Sanchez-Amat, A. (2010). Taxonomic study of Marinomonas strains isolated from the seagrass Posidonia oceanica, with descriptions of Marinomonas balearica sp. nov. and Marinomonas pollencensis sp. nov. Int J Syst Evol Microbiol 60(Pt 1): 93-98.
20. Gomez, D., Lucas-Elio, P., Solano, F. and Sanchez-Amat, A. (2010). Both genes in the Marinomonas mediterranea lodAB operon are required for the expression of the antimicrobial protein lysine oxidase. Mol Microbiol 75(2): 462-473.
21. Molina-Quintero, L. R., Lucas-Elio, P. and Sanchez-Amat, A. (2010). Regulation of the Marinomonas mediterranea antimicrobial protein lysine oxidase by L-lysine and the sensor histidine kinase PpoS. Appl Environ Microbiol 76(18): 6141-6149.
22. Sanchez-Amat, A., Solano, F. and Lucas-Elio, P. (2010). Finding new enzymes from bacterial physiology: a successful approach illustrated by the detection of novel oxidases in Marinomonas mediterranea. Mar Drugs 8(3): 519-541.
23. Gomez, D., Espinosa, E., Bertazzo, M., Lucas-Elio, P., Solano, F. and Sanchez-Amat, A. (2008). The macromolecule with antimicrobial activity synthesized by Pseudoalteromonas luteoviolacea strains is an L-amino acid oxidase. Appl Microbiol Biotechnol 79(6): 925-930.
24. Mai-Prochnow, A., Lucas-Elio, P., Egan, S., Thomas, T., Webb, J. S., Sanchez-Amat, A. and Kjelleberg, S. (2008). Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria. J Bacteriol 190(15): 5493-5501.
25. Lopez-Serrano, D., Solano, F. and Sanchez-Amat, A. (2007). Involvement of a novel copper chaperone in tyrosinase activity and melanin synthesis in Marinomonas mediterranea. Microbiology 153(Pt 7): 2241-2249.