Education
Ph.D. in Developmental Biology, Hiroshima University, 1999
Current position
Assistant Professor, the Southern California Research Center for ALPD & Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California
Publication (since 2008)
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Li, Y., Wang, J. and Asahina, K. (2013). Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A 110(6): 2324-2329.
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Yin, C., Evason, K. J., Asahina, K. and Stainier, D. Y. (2013). Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest 123(5): 1902-1910.
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Asahina, K. (2012). Hepatic stellate cell progenitor cells. J Gastroenterol Hepatol 27 Suppl 2: 80-84.
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Yang, M. D., Chiang, Y. M., Higashiyama, R., Asahina, K., Mann, D. A., Mann, J., Wang, C. C. and Tsukamoto, H. (2012). Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor gamma in hepatic stellate cells for their antifibrotic effect. Hepatology 55(4): 1271-1281.
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Zhu, N. L., Asahina, K., Wang, J., Ueno, A., Lazaro, R., Miyaoka, Y., Miyajima, A. and Tsukamoto, H. (2012). Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem 287(13): 10355-10367.
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Asahina, K., Zhou, B., Pu, W. T. and Tsukamoto, H. (2011). Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53(3): 983-995.
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Asahina, K., Tsai, S. Y., Li, P., Ishii, M., Maxson, R. E., Jr., Sucov, H. M. and Tsukamoto, H. (2009). Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology 49(3): 998-1011.
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Gaucher, G., Asahina, K., Wang, J. and Leroux, J. C. (2009). Effect of poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules 10(2): 408-416.
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Machida, K., Tsukamoto, H., Mkrtchyan, H., Duan, L., Dynnyk, A., Liu, H. M., Asahina, K., Govindarajan, S., Ray, R., Ou, J. H., Seki, E., Deshaies, R., Miyake, K. and Lai, M. M. (2009). Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A 106(5): 1548-1553.
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Shikanai, M., Asahina, K., Iseki, S., Teramoto, K., Nishida, T., Shimizu-Saito, K., Ota, M., Eto, K. and Teraoka, H. (2009). A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem Biophys Res Commun 381(2): 276-282.
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Cheng, J. H., She, H., Han, Y. P., Wang, J., Xiong, S., Asahina, K. and Tsukamoto, H. (2008). Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 294(1): G39-49.
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Fujimori, H., Asahina, K., Shimizu-Saito, K., Ikeda, R., Tanaka, Y., Teramoto, K., Morita, I. and Teraoka, H. (2008). Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J Hepatol 48(6): 962-973.