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Hiroshi Okuda

Tsuruoka Metabolomics Laboratory, National Cancer Center, Japan, Japan

Personal information

Education

Ph.D, Kindai University, Japan, 2007

Current position

Researcher, Tsuruoka Metabolomics Laboratory, National Cancer Center, Japan

Publications

  1. Okuda, H., Stanojevic, B., Kanai, A., Kawamura, T., Takahashi, S., Matsui, H., Takaori-Kondo, A. and Yokoyama, A. (2017). Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. J Clin Invest 127(5): 1918-1931.
  2. MacLean, J. A., 2nd, King, M. L., Okuda, H. and Hayashi, K. (2016). WNT7A Regulation by miR-15b in Ovarian Cancer. PLoS One 11(5): e0156109.
  3. Okuda, H., Takahashi, S., Takaori-Kondo, A. and Yokoyama, A. (2016). TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription. Cell Cycle 15(20): 2712-2722.
  4. King, M. L., Lindberg, M. E., Stodden, G. R., Okuda, H., Ebers, S. D., Johnson, A., Montag, A., Lengyel, E., MacLean Ii, J. A. and Hayashi, K. (2015). WNT7A/beta-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene 34(26): 3452-3462.
  5. Okuda, H., Kanai, A., Ito, S., Matsui, H. and Yokoyama, A. (2015). AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription. Nat Commun 6: 8869.
  6. Okuda, H., Kawaguchi, M., Kanai, A., Matsui, H., Kawamura, T., Inaba, T., Kitabayashi, I. and Yokoyama, A. (2014). MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters. Nucleic Acids Res 42(7): 4241-4256.
  7. Okuda, H., Xing, F., Pandey, P. R., Sharma, S., Watabe, M., Pai, S. K., Mo, Y. Y., Iiizumi-Gairani, M., Hirota, S., Liu, Y., Wu, K., Pochampally, R. and Watabe, K. (2013). miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res 73(4): 1434-1444.
  8. Xing, F., Kobayashi, A., Okuda, H., Watabe, M., Pai, S. K., Pandey, P. R., Hirota, S., Wilber, A., Mo, Y. Y., Moore, B. E., Liu, W., Fukuda, K., Iiizumi, M., Sharma, S., Liu, Y., Wu, K., Peralta, E. and Watabe, K. (2013). Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med 5(3): 384-396.
  9. Okuda, H., Kobayashi, A., Xia, B., Watabe, M., Pai, S. K., Hirota, S., Xing, F., Liu, W., Pandey, P. R., Fukuda, K., Modur, V., Ghosh, A., Wilber, A. and Watabe, K. (2012). Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res 72(2): 537-547.
  10. Liu, W., Xing, F., Iiizumi-Gairani, M., Okuda, H., Watabe, M., Pai, S. K., Pandey, P. R., Hirota, S., Kobayashi, A., Mo, Y. Y., Fukuda, K., Li, Y. and Watabe, K. (2012). N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med 4(2): 93-108.
  11. Yoshioka, S., King, M. L., Ran, S., Okuda, H., MacLean, J. A., 2nd, McAsey, M. E., Sugino, N., Brard, L., Watabe, K. and Hayashi, K. (2012). WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway. Mol Cancer Res 10(3): 469-482.
  12. Liu, W., Iiizumi-Gairani, M., Okuda, H., Kobayashi, A., Watabe, M., Pai, S. K., Pandey, P. R., Xing, F., Fukuda, K., Modur, V., Hirota, S., Suzuki, K., Chiba, T., Endo, M., Sugai, T. and Watabe, K. (2011). KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem 286(21): 18949-18959.
  13. Liu, W., Furuta, E., Shindo, K., Watabe, M., Xing, F., Pandey, P. R., Okuda, H., Pai, S. K., Murphy, L. L., Cao, D., Mo, Y. Y., Kobayashi, A., Iiizumi, M., Fukuda, K., Xia, B. and Watabe, K. (2011). Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway. Breast Cancer Res Treat 128(1): 57-68.
  14. Xing, F., Okuda, H., Watabe, M., Kobayashi, A., Pai, S. K., Liu, W., Pandey, P. R., Fukuda, K., Hirota, S., Sugai, T., Wakabayshi, G., Koeda, K., Kashiwaba, M., Suzuki, K., Chiba, T., Endo, M., Mo, Y. Y. and Watabe, K. (2011). Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene 30(39): 4075-4086.
  15. Pandey, P. R., Okuda, H., Watabe, M., Pai, S. K., Liu, W., Kobayashi, A., Xing, F., Fukuda, K., Hirota, S., Sugai, T., Wakabayashi, G., Koeda, K., Kashiwaba, M., Suzuki, K., Chiba, T., Endo, M., Fujioka, T., Tanji, S., Mo, Y. Y., Cao, D., Wilber, A. C. and Watabe, K. (2011). Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res Treat 130(2): 387-398.
  16. Kobayashi, A., Okuda, H., Xing, F., Pandey, P. R., Watabe, M., Hirota, S., Pai, S. K., Liu, W., Fukuda, K., Chambers, C., Wilber, A. and Watabe, K. (2011). Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med 208(13): 2641-2655.
  17. Furuta, E., Okuda, H., Kobayashi, A. and Watabe, K. (2010). Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta 1805(2): 141-152. .
  18. Okuda, H., Sakuhana, C., Yamamoto, R., Mizukami, Y., Kawai, R., Sumita, Y., Koga, M., Shirai, M. and Matsuda, K. (2008). The intermediate domain defines broad nucleotide selectivity for protein folding in Chlamydophila GroEL1. J Biol Chem 283: 9300-9307.
  19. Iiizumi, M., Bandyopadhyay, S., Pai, S. K., Watabe, M., Hirota, S., Hosobe, S., Tsukada, T., Miura, K., Saito, K., Furuta, E., Liu, W., Xing, F., Okuda, H., Kobayashi, A. and Watabe, K. (2008). RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res 68(18): 7613-7620.
  20. Tan, J., Galligan, J. J. and Hollingworth, R. M. (2007). Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons. Neurotoxicology 28(4): 829-842.
  21. Okuda, H., Sakuhana, C., Yamamoto, R., Kawai, R., Mizukami, Y. and Matsuda, K. (2007). Effects of divalent cations on encapsulation and release in the GroEL-assisted folding. Biometals 20(6): 903-910.
  22. Ihara, M., Ishida, C., Okuda, H., Ozoe, Y. and Matsuda, K. (2005). Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and gamma-hexachlorocyclohexane (gamma-HCH) on gamma-aminobutyric acid- and glutamate-induced responses of American cockroach neurons. Invert Neurosci 5(3-4): 157-164
  23. Fukuoka, K., Sawabe, A., Sugimoto, T., Koga, M., Okuda, H., Kitayama, T., Shirai, M., Komai, K., Komemushi, S. and Matsuda, K. (2004). Inhibitory actions of several natural products on proliferation of rat vascular smooth muscle cells induced by Hsp60 from Chlamydia pneumoniae J138. J Agric Food Chem 52(20): 6326-6329.
  24. Shimomura, M., Okuda, H., Matsuda, K., Komai, K., Akamatsu, M. and Sattelle, D. B. (2002). Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. Br J Pharmacol 137(2): 162-169.