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Masahiko Watanabe

Department of Anatomy, Hokkaido University Graduate School of Medicine, Japan

Personal information

Education

M.D., Ph.D. in Anatomy, Tsukuba Univeristy, 1988

Current position

Professor in Anatomy Department, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Publications (selected)

  1. Kano M, Watanabe M: Cerebellar circuits. In: Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Healthy and Diseased Brain, volume 3 (eds, Rubenstein JL, Rakic P), pp.75-93, 2013, Elsevier, Amsterdam.
  2. Kano M, Watanabe M: Synaptogenesis and synapse elimination. In: Handbook of the Cerebellum and Cerebellar Disorders. (eds, Manto M, Gruol DL, Schmahmann N, Koibuchi N, Rossi F), 2013, pp281-299, Springer.
  3. Miyazaki, T., Yamasaki, M., Hashimoto, K., Yamazaki, M., Abe, M., Usui, H., Kano, M., Sakimura, K. and Watanabe, M. (2012). Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. J Neurosci 32(4): 1311-1328.
  4. Kudo, T., Uchigashima, M., Miyazaki, T., Konno, K., Yamasaki, M., Yanagawa, Y., Minami, M. and Watanabe, M. (2012). Three types of neurochemical projection from the bed nucleus of the stria terminalis to the ventral tegmental area in adult mice. J Neurosci 32(50): 18035-18046.
  5. Iwakura, A., Uchigashima, M., Miyazaki, T., Yamasaki, M. and Watanabe, M. (2012). Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation. J Neurosci 32(27): 9438-9448.
  6. Watanabe, M. and Kano, M. (2011). Climbing fiber synapse elimination in cerebellar Purkinje cells. Eur J Neurosci 34(10): 1697-1710.
  7. Miyazaki, T., Yamasaki, M., Hashimoto, K., Yamazaki, M., Abe, M., Usui, H., Kano, M., Sakimura, K. and Watanabe, M. (2012). Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. J Neurosci 32(4): 1311-1328.
  8. Ichikawa, R., Yamasaki, M., Miyazaki, T., Konno, K., Hashimoto, K., Tatsumi, H., Inoue, Y., Kano, M. and Watanabe, M. (2011). Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells. J Neurosci 31(47): 16916-16927.
  9. Uchigashima, M., Yamazaki, M., Yamasaki, M., Tanimura, A., Sakimura, K., Kano, M. and Watanabe, M. (2011). Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci 31(21): 7700-7714.
  10. Yoshida, T., Uchigashima, M., Yamasaki, M., Katona, I., Yamazaki, M., Sakimura, K., Kano, M., Yoshioka, M. and Watanabe, M. (2011). Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. Proc Natl Acad Sci U S A 108(7): 3059-3064.
  11. Yamasaki, M., Miyazaki, T., Azechi, H., Abe, M., Natsume, R., Hagiwara, T., Aiba, A., Mishina, M., Sakimura, K. and Watanabe, M. (2011). Glutamate receptor delta2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells. J Neurosci 31(9): 3362-3374.
  12. Miyazaki, T., Yamasaki, M., Takeuchi, T., Sakimura, K., Mishina, M. and Watanabe, M. (2010). Ablation of glutamate receptor GluRdelta2 in adult Purkinje cells causes multiple innervation of climbing fibers by inducing aberrant invasion to parallel fiber innervation territory. J Neurosci 30(45): 15196-15209.
  13. Yamasaki, M., Matsui, M. and Watanabe, M. (2010). Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission. J Neurosci 30(12): 4408-4418.
  14. Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M. and Watanabe, M. (2009). Endocannabinoid-mediated control of synaptic transmission. Physiol Rev 89(1): 309-380.
  15. Takasaki, C., Okada, R., Mitani, A., Fukaya, M., Yamasaki, M., Fujihara, Y., Shirakawa, T., Tanaka, K. and Watanabe, M. (2008). Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. J Neurosci 28(19): 4995-5006.
  16. Uchigashima, M., Narushima, M., Fukaya, M., Katona, I., Kano, M. and Watanabe, M. (2007). Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J Neurosci 27(14): 3663-3676.
  17. Yoshida, T., Fukaya, M., Uchigashima, M., Miura, E., Kamiya, H., Kano, M. and Watanabe, M. (2006). Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J Neurosci 26(18): 4740-4751.
  18. Miyazaki, T., Hashimoto, K., Shin, H. S., Kano, M. and Watanabe, M. (2004). P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells. J Neurosci 24(7): 1734-1743.
  19. Fukaya, M., Kato, A., Lovett, C., Tonegawa, S. and Watanabe, M. (2003). Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A 100(8): 4855-4860.
  20. Sakai, K., Shimizu, H., Koike, T., Furuya, S. and Watanabe, M. (2003). Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J Neurosci 23(2): 550-560.
  21. Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y. and Watanabe, M. (2002). Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. J Neurosci 22(19): 8487-8503.
  22. Yamasaki, M., Yamada, K., Furuya, S., Mitoma, J., Hirabayashi, Y. and Watanabe, M. (2001). 3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain. J Neurosci 21(19): 7691-7704.
  23. Yamada, K., Fukaya, M., Shibata, T., Kurihara, H., Tanaka, K., Inoue, Y. and Watanabe, M. (2000). Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J Comp Neurol 418(1): 106-120.
  24. Yamada, K., Watanabe, M., Shibata, T., Nagashima, M., Tanaka, K. and Inoue, Y. (1998). Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J Neurosci 18(15): 5706-5713.
  25. Watanabe, M., Fukaya, M., Sakimura, K., Manabe, T., Mishina, M. and Inoue, Y. (1998). Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield. Eur J Neurosci 10(2): 478-487.
  26. Shibata, T., Yamada, K., Watanabe, M., Ikenaka, K., Wada, K., Tanaka, K. and Inoue, Y. (1997). Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci 17(23): 9212-9219.
  27. Kurihara, H., Hashimoto, K., Kano, M., Takayama, C., Sakimura, K., Mishina, M., Inoue, Y. and Watanabe, M. (1997). Impaired parallel fiber-->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta2 subunit. J Neurosci 17(24): 9613-9623.
  28. Watanabe, M., Osada, J., Aratani, Y., Kluckman, K., Reddick, R., Malinow, M. R. and Maeda, N. (1995). Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A 92(5): 1585-1589.
  29. Watanabe, M., Inoue, Y., Sakimura, K. and Mishina, M. (1993). Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J Comp Neurol 338(3): 377-390.
  30. Watanabe, M., Inoue, Y., Sakimura, K. and Mishina, M. (1992). Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3(12): 1138-1140.