Education

PhD, Fribourg University, Switzerland

Current position

Director, The Foundation Swiss Vitamin Institute, The Foundation Swiss Vitamin Institute, Switzerland

Publications

1. Debowski, A. W., Walton, S. M., Chua, E. G., Tay, A. C., Liao, T., Lamichhane, B., Himbeck, R., Stubbs, K. A., Marshall, B. J., Fulurija, A. and Benghezal, M. (2017). Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection. PLoS Pathog 13(6): e1006464.
2. Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H. O., Haslam, S. M., Dell, A., Stubbs, K. A., Marshall, B. J. and Benghezal, M. (2017). Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains. Microb Cell 4(5): 175-178.
   
3. Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H. O., Fulurija, A., Haslam, S. M., Mulloy, B., Dell, A., Stubbs, K. A., Marshall, B. J. and Benghezal, M. (2017). The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains. PLoS Pathog 13(3): e1006280.
   
4. Li, H., Debowski, A. W., Liao, T., Tang, H., Nilsson, H. O., Marshall, B. J., Stubbs, K. A. and Benghezal, M. (2017). Understanding protein glycosylation pathways in bacteria. Future Microbiol 12: 59-72.
   
5. Stenstrom, B., Windsor, H. M., Fulurija, A., Benghezal, M., Kumarasinghe, M. P., Kimura, K., Tay, C. Y., Viiala, C. H., Ee, H. C., Lu, W., Schoep, T. D., Webberley, K. M. and Marshall, B. J. (2016). Helicobacter pylori overcomes natural immunity in repeated infections. Clin Case Rep 4(11): 1026-1033.
   
6. Li, H., Liao, T., Debowski, A. W., Tang, H., Nilsson, H. O., Stubbs, K. A., Marshall, B. J. and Benghezal, M. (2016). Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori. Helicobacter 21(6): 445-461.
   
7. Debowski, A. W., Sehnal, M., Liao, T., Stubbs, K. A., Marshall, B. J. and Benghezal, M. (2015). Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori. Appl Environ Microbiol 81(23): 7969-7980.
   
8. Kumar, N., Mariappan, V., Baddam, R., Lankapalli, A. K., Shaik, S., Goh, K. L., Loke, M. F., Perkins, T., Benghezal, M., Hasnain, S. E., Vadivelu, J., Marshall, B. J. and Ahmed, N. (2015). Comparative genomic analysis of Helicobacter pylori from Malaysia identifies three distinct lineages suggestive of differential evolution. Nucleic Acids Res 43(1): 324-335.
   
9. Gauntlett, J. C., Nilsson, H. O., Fulurija, A., Marshall, B. J. and Benghezal, M. (2014). Phase-variable restriction/modification systems are required for Helicobacter pylori colonization. Gut Pathog 6: 35.
   
10. Benghezal, M., Gauntlett, J. C., Debowski, A. W., Fulurija, A., Nilsson, H. O., Marshall, B. J. (2014). Persistence of Helicobacter pylori infection: Genetic and epigenetic diversity. Helicobacter pylori Infection. In: Bruna, R. (Ed). InTech.
    
11. Debowski, A. W., Verbrugghe, P., Sehnal, M., Marshall, B. J. and Benghezal, M. (2013). Development of a tetracycline-inducible gene expression system for the study of Helicobacter pylori pathogenesis. Appl Environ Microbiol 79(23): 7351-7359.
    
12. Rohrer, S., Holsten, L., Weiss, E., Benghezal, M., Fischer, W. and Haas, R. (2012). Multiple pathways of plasmid DNA transfer in Helicobacter pylori. PLoS One 7(9): e45623.
    
13. Debowski, A. W., Carnoy, C., Verbrugghe, P., Nilsson, H. O., Gauntlett, J. C., Fulurija, A., Camilleri, T., Berg, D. E., Marshall, B. J. and Benghezal, M. (2012). Xer recombinase and genome integrity in Helicobacter pylori, a pathogen without topoisomerase IV. PLoS One 7(4): e33310.
    
14. Debowski, A. W., Gauntlett, J. C., Li, H., Liao, T., Sehnal, M., Nilsson, H. O., Marshall, B. J. and Benghezal, M. (2012). Xer-cise in Helicobacter pylori: one-step transformation for the construction of markerless gene deletions. Helicobacter 17(6): 435-443.
    
15. Schoep, T. D., Fulurija, A., Good, F., Lu, W., Himbeck, R. P., Schwan, C., Choi, S. S., Berg, D. E., Mittl, P. R., Benghezal, M. and Marshall, B. J. (2010). Surface properties of Helicobacter pylori urease complex are essential for persistence. PLoS One 5(11): e15042.
    
16. Styer, C. M., Hansen, L. M., Cooke, C. L., Gundersen, A. M., Choi, S. S., Berg, D. E., Benghezal, M., Marshall, B. J., Peek, R. M., Jr., Boren, T. and Solnick, J. V. (2010). Expression of the BabA adhesin during experimental infection with Helicobacter pylori. Infect Immun 78(4): 1593-1600.
    
17. Dumrese, C., Slomianka, L., Ziegler, U., Choi, S. S., Kalia, A., Fulurija, A., Lu, W., Berg, D. E., Benghezal, M., Marshall, B. and Mittl, P. R. (2009). The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype. FEBS Lett 583(10): 1637-1643.
    
18. Froquet, R., Cherix, N., Birke, R., Benghezal, M., Cameroni, E., Letourneur, F., Mosch, H. U., De Virgilio, C. and Cosson, P. (2008). Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. J Biol Chem 283(11): 6764-6772.
    
19. Alibaud, L., Kohler, T., Coudray, A., Prigent-Combaret, C., Bergeret, E., Perrin, J., Benghezal, M., Reimmann, C., Gauthier, Y., van Delden, C., Attree, I., Fauvarque, M. O. and Cosson, P. (2008). Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model. Cell Microbiol 10(3): 729-740.
    
20. Jaquenoud, M., Pagac, M., Signorell, A., Benghezal, M., Jelk, J., Butikofer, P. and Conzelmann, A. (2008). The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase. Mol Microbiol 67(1): 202-212.
    
21. Benghezal, M., Roubaty, C., Veepuri, V., Knudsen, J. and Conzelmann, A. (2007). SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast. J Biol Chem 282(42): 30845-30855.
    
22. Benghezal, M., Adam, E., Lucas, A., Burn, C., Orchard, M. G., Deuschel, C., Valentino, E., Braillard, S., Paccaud, J. P. and Cosson, P. (2007). Inhibitors of bacterial virulence identified in a surrogate host model. Cell Microbiol 9(5): 1336-1342.
    
23. Cornillon, S., Gebbie, L., Benghezal, M., Nair, P., Keller, S., Wehrle-Haller, B., Charette, S. J., Bruckert, F., Letourneur, F. and Cosson, P. (2006). An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features. EMBO Rep 7(6): 617-621.
    
24. Benghezal, M., Fauvarque, M. O., Tournebize, R., Froquet, R., Marchetti, A., Bergeret, E., Lardy, B., Klein, G., Sansonetti, P., Charette, S. J. and Cosson, P. (2006). Specific host genes required for the killing of Klebsiella bacteria by phagocytes. Cell Microbiol 8(1): 139-148.
    
25. Gebbie, L., Benghezal, M., Cornillon, S., Froquet, R., Cherix, N., Malbouyres, M., Lefkir, Y., Grangeasse, C., Fache, S., Dalous, J., Bruckert, F., Letourneur, F. and Cosson, P. (2004). Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium. Mol Biol Cell 15(8): 3915-3925.
    
26. Alibaud, L., Cosson, P. and Benghezal, M. (2003). Dictyostelium discoideum transformation by oscillating electric field electroporation. Biotechniques 35(1): 78-80, 82-73.
    
27. Benghezal, M., Cornillon, S., Gebbie, L., Alibaud, L., Bruckert, F., Letourneur, F. and Cosson, P. (2003). Synergistic control of cellular adhesion by transmembrane 9 proteins. Mol Biol Cell 14(7): 2890-2899.
    
28. Meyer, U., Fraering, P., Bosson, R., Imhof, I., Benghezal, M., Vionnet, C. and Conzelmann, A. (2002). The glycosylphosphatidylinositol (GPI) signal sequence of human placental alkaline phosphatase is not recognized by human Gpi8p in the context of the yeast GPI anchoring machinery. Mol Microbiol 46(3): 745-748.
    
29. Cosson, P., Zulianello, L., Join-Lambert, O., Faurisson, F., Gebbie, L., Benghezal, M., Van Delden, C., Curty, L. K. and Kohler, T. (2002). Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system. J Bacteriol 184(11): 3027-3033.
    
30. Cornillon, S., Dubois, A., Bruckert, F., Lefkir, Y., Marchetti, A., Benghezal, M., De Lozanne, A., Letourneur, F. and Cosson, P. (2002). Two members of the beige/CHS (BEACH) family are involved at different stages in the organization of the endocytic pathway in Dictyostelium. J Cell Sci 115(Pt 4): 737-744.
    
31. Ravanel, K., de Chassey, B., Cornillon, S., Benghezal, M., Zulianello, L., Gebbie, L., Letourneur, F. and Cosson, P. (2001). Membrane sorting in the endocytic and phagocytic pathway of Dictyostelium discoideum. Eur J Cell Biol 80(12): 754-764.
    
32. Benghezal, M., Gotthardt, D., Cornillon, S. and Cosson, P. (2001). Localization of the Rh50-like protein to the contractile vacuole in Dictyostelium. Immunogenetics 52(3-4): 284-288.
    
33. Cornillon, S., Pech, E., Benghezal, M., Ravanel, K., Gaynor, E., Letourneur, F., Bruckert, F. and Cosson, P. (2000). Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis. J Biol Chem 275(44): 34287-34292.
    
34. Benghezal, M., Wasteneys, G. O. and Jones, D. A. (2000). The C-terminal dilysine motif confers endoplasmic reticulum localization to type I membrane proteins in plants. Plant Cell 12(7): 1179-1201.
    
35. Meyer, U., Benghezal, M., Imhof, I. and Conzelmann, A. (2000). Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins. Biochemistry 39(12): 3461-3471.
    
36. Benachour, A., Sipos, G., Flury, I., Reggiori, F., Canivenc-Gansel, E., Vionnet, C., Conzelmann, A. and Benghezal, M. (1999). Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. J Biol Chem 274(21): 15251-15261.
    
37. Benghezal, M., Benachour, A., Rusconi, S., Aebi, M. and Conzelmann, A. (1996). Yeast Gpi8p is essential for GPI anchor attachment onto proteins. EMBO J 15(23): 6575-6583.
    
38. Benghezal, M., Lipke, P. N. and Conzelmann, A. (1995). Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae. J Cell Biol 130(6): 1333-1344.