Jing-Ren Zhang, Center for Infectious Disease Research, School of Medicine, Tsinghua University, China

Jing-Ren Zhang

Center for Infectious Disease Research, School of Medicine, Tsinghua University, China

Research fields

Microbiology

Personal information

Education

PHD, University of Texas Health Science Center, Houston, TX, USA, 1997

Current position

Professor, School of Medicine, Tsinghua University , China

Publications (since 2003)

Li, J., Wang, J., Jiao, F. and Zhang, J. R. (2017). Observation of pneumococcal phase variation in colony morphology. Bio Protoc 7(15): e2434.
Yu, Y., Li, J., Jiang, L., Zhang, J. R. and Zu, L. (2017). Catalytic Enantioselective Aza-pinacol Rearrangement. Angew Chem Int Ed Engl 56(31): 9217-9221.
Liu, X., Gallay, C., Kjos, M., Domenech, A., Slager, J., van Kessel, S. P., Knoops, K., Sorg, R. A., Zhang, J. R. and Veening, J. W. (2017). High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae. Mol Syst Biol 13(5): 931.
Liu, B., Liu, X., Zhang, J. R. and Liu, G. (2017). A Natural Lipotrisaccharide and Its Derivatives Selectively Lyse Streptococcus pneumoniae via Interaction with Cell Membrane. ACS Infect Dis 3(6): 438-453.
Li, J., Li, J. W., Feng, Z., Wang, J., An, H., Liu, Y., Wang, Y., Wang, K., Zhang, X., Miao, Z., Liang, W., Sebra, R., Wang, G., Wang, W. C. and Zhang, J. R. (2016). Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae. PLoS Pathog 12(7): e1005762.
Wen, Z., Liu, Y., Qu, F. and Zhang, J. R. (2016). Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae. Sci Rep 6: 30176.
Li, G., Liang, Z., Wang, X., Yang, Y., Shao, Z., Li, M., Ma, Y., Qu, F., Morrison, D. A. and Zhang, J. R. (2016). Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence. Infect Immun 84(6): 1887-1901.
He, L., Nair, M. K., Chen, Y., Liu, X., Zhang, M., Hazlett, K. R., Deng, H. and Zhang, J. R. (2016). The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host. Infect Immun 84(5): 1387-1402.
Bai, X. H., Li, Q., Jiang, Y. L., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2016). Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB. Methods Mol Biol 1440: 271-283.
Yang, H., Liu, X., Li, Q., Li, L., Zhang, J. R. and Tang, Y. (2016). Total synthesis and preliminary SAR study of (+/-)-merochlorins A and B. Org Biomol Chem 14(1): 198-205.
Yang, T., Chen, G., Sang, Z., Liu, Y., Yang, X., Chang, Y., Long, H., Ang, W., Tang, J., Wang, Z., Li, G., Yang, S., Zhang, J., Wei, Y. and Luo, Y. (2015). Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies. J Med Chem 58(16): 6389-6409.
Wang, L., Jiang, Y. L., Zhang, J. R., Zhou, C. Z. and Chen, Y. (2015). Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae. PLoS One 10(3): e0120467.
Wen, Z., Sertil, O., Cheng, Y., Zhang, S., Liu, X., Wang, W. C. and Zhang, J. R. (2015). Sequence elements upstream of the core promoter are necessary for full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infect Immun 83(5): 1957-1972.
Achila, D., Liu, A., Banerjee, R., Li, Y., Martinez-Hackert, E., Zhang, J. R. and Yan, H. (2015). Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae. Biochem J 465(2): 325-335.
Feng, Z., Li, J., Zhang, J. R. and Zhang, X. (2014). qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data. Nucleic Acids Res 42(22): 13488-13499.
Zhu, D., Wang, L., Shang, G., Liu, X., Zhu, J., Lu, D., Wang, L., Kan, B., Zhang, J. R. and Xiang, Y. (2014). Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Mol Cell 55(6): 931-937.
Zeng, X. F., Ma, Y., Yang, L., Zhou, L., Xin, Y., Chang, L., Zhang, J. R. and Hao, X. (2014). A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae. Res Microbiol 165(8): 630-638.
Song, Y., Li, Q., Liu, X., Chen, Y., Zhang, Y., Sun, A., Zhang, W., Zhang, J. and Ju, J. (2014). Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria. J Nat Prod 77(8): 1937-1941.
Bai, X. H., Chen, H. J., Jiang, Y. L., Wen, Z., Huang, Y., Cheng, W., Li, Q., Qi, L., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2014). Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J Biol Chem 289(34): 23403-23416.
Yang, Y. H., Jiang, Y. L., Zhang, J., Wang, L., Bai, X. H., Zhang, S. J., Ren, Y. M., Li, N., Zhang, Y. H., Zhang, Z., Gong, Q., Mei, Y., Xue, T., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2014). Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLoS Pathog 10(6): e1004169.
Pan, X., Yang, Y. and Zhang, J. R. (2014). Molecular basis of host specificity in human pathogenic bacteria. Emerg Microbes Infect 3(3): e23.
Gupta, R., Yang, J., Dong, Y., Swiatlo, E., Zhang, J. R., Metzger, D. W. and Bai, G. (2013). Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infect Immun 81(10): 3903-3911.
El Qaidi, S., Yang, J., Zhang, J. R., Metzger, D. W. and Bai, G. (2013). The vitamin B(6) biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection. J Bacteriol 195(10): 2187-2196.
Li, G., Hu, F. Z., Yang, X., Cui, Y., Yang, J., Qu, F., Gao, G. F. and Zhang, J. R. (2012). Complete genome sequence of Streptococcus pneumoniae strain ST556, a multidrug-resistant isolate from an otitis media patient. J Bacteriol 194(12): 3294-3295.
Han, H., Liu, C., Wang, Q., Xuan, C., Zheng, B., Tang, J., Yan, J., Zhang, J., Li, M., Cheng, H., Lu, G. and Gao, G. F. (2012). The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology 158(Pt 7): 1852-1866.
Su, J., Asare, R., Yang, J., Nair, M. K., Mazurkiewicz, J. E., Abu-Kwaik, Y. and Zhang, J. R. (2011). The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS. Front Microbiol 2: 83.
Zhang, Q., Gao, F., Peng, H., Cheng, H., Liu, Y., Tang, J., Thompson, J., Wei, G., Zhang, J., Du, Y., Yan, J. and Gao, G. F. (2009). Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism. J Bacteriol 191(18): 5832-5837.
Chen, H., Ma, Y., Yang, J., O'Brien, C. J., Lee, S. L., Mazurkiewicz, J. E., Haataja, S., Yan, J. H., Gao, G. F. and Zhang, J. R. (2007). Genetic requirement for pneumococcal ear infection. PLoS One 3(8): e2950.
Lu, L., Ma, Z., Jokiranta, T. S., Whitney, A. R., DeLeo, F. R. and Zhang, J. R. (2008). Species-specific interaction of Streptococcus pneumoniae with human complement factor H. J Immunol 181(10): 7138-7146.
Ma, Z., and Zhang, J. R. (2007). RR06 activates the transcription of spr1996 and cbpA in Streptococcus pneumoniae. J Bacteriol 189: 2497-2509.
Su, J., Yang, J., Zhao, D., Kawula, T. H., Banas, J. A. and Zhang, J. R. (2007). Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 75(6): 3089-3101.
Lu, L., Ma, Y. and Zhang, J. R. (2006). Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. J Biol Chem 281(22): 15464-15474.
Lu, L., Lamm, M. E., Li, H., Corthesy, B. and Zhang, J. R. (2003). The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J Biol Chem 278(48): 48178-48187.