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Pankaj Kapahi

Professor, Buck Institute for Research on Aging, Novato, USA

Research fields Cell Biology

Personal information

Education

Ph.D, University of Manchester, UK, 1998

Publications

  1. Zee, T., Bose, N., Zee, J., Beck, J. N., Yang, S., Parihar, J., Yang, M., Damodar, S., Hall, D., O'Leary, M. N., Ramanathan, A., Gerona, R. R., Killilea, D. W., Chi, T., Tischfield, J., Sahota, A., Kahn, A., Stoller, M. L. and Kapahi, P. (2017). alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med 23(3): 288-290.
  2. Kapahi, P., Kaeberlein, M. and Hansen, M. (2016). Dietary restriction and lifespan: lessons from invertebrate models. Ageing Res Rev.
  3. Khanna, A., Kumar, J., Vargas, M. A., Barrett, L., Katewa, S., Li, P., McCloskey, T., Sharma, A., Naude, N., Nelson, C., Brem, R., Killilea, D. W., Mooney, S. D., Gill, M. and Kapahi, P. (2016). A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans. Sci Rep 6: 38764.
  4. Nelson, C. S., Beck, J. N., Wilson, K. A., Pilcher, E. R., Kapahi, P. and Brem, R. B. (2016). Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. BMC Genomics 17(1): 867.
  5. Luis, N. M., Wang, L., Ortega, M., Deng, H., Katewa, S. D., Li, P. W., Karpac, J., Jasper, H. and Kapahi, P. (2016). Intestinal IRE1 is required for increased triglyceride metabolism and longer lifespan under dietary restriction. Cell Rep 17(5): 1207-1216.
  6. Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. (2016). A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive alpha-dicarbonyl detoxification. Curr Biol 26(22): 3014-3025.
  7. Kumar, J., Barhydt, T., Awasthi, A., Lithgow, G. J., Killilea, D. W. and Kapahi, P. (2016). Zinc levels modulate lifespan through multiple longevity pathways in Caenorhabditis elegans. PLoS One 11(4): e0153513. 
  8. Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., Ramanathan, A., Sehgal, A., Giebultowicz, J. M. and Kapahi, P. (2016). Peripheral circadian clocks mediate dietary restriction-dependent changes in lifespan and fat metabolism in Drosophila. Cell Metab 23(1): 143-154.
  9. Zhang, Q., Du, G., John, V., Kapahi, P. and Bredesen, D. E. (2015). Alzheimer's model develops early ADHD syndrome. J Neurol Neurophysiol 6(6): 1-6.
  10. Liu, S., Uppal, H., Demaria, M., Desprez, P. Y., Campisi, J. and Kapahi, P. (2015). Simvastatin suppresses breast cancer cell proliferation induced by senescent cells. Sci Rep 5: 17895.
  11. Laberge, R. M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., Nelson, P. S. and Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol 17(8): 1049-1061.
  12. Laye, M. J., Tran, V., Jones, D. P., Kapahi, P. and Promislow, D. E. (2015). The effects of age and dietary restriction on the tissue-specific metabolome of Drosophila. Aging Cell 14(5): 797-808.
  13. Killilea, D. W., Westropp, J. L., Shiraki, R., Mellema, M., Larsen, J., Kahn, A. J., Kapahi, P., Chi, T. and Stoller, M. L. (2015). Elemental content of calcium oxalate stones from a canine model of urinary stone disease. PLoS One 10(6): e0128374.
  14. Chi, T., Kim, M. S., Lang, S., Bose, N., Kahn, A., Flechner, L., Blaschko, S. D., Zee, T., Muteliefu, G., Bond, N., Kolipinski, M., Fakra, S. C., Mandel, N., Miller, J., Ramanathan, A., Killilea, D. W., Bruckner, K., Kapahi, P. and Stoller, M. L. (2015). A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS One 10(5): e0124150.
  15. Klang, I. M., Schilling, B., Sorensen, D. J., Sahu, A. K., Kapahi, P., Andersen, J. K., Swoboda, P., Killilea, D. W., Gibson, B. W. and Lithgow, G. J. (2014). Iron promotes protein insolubility and aging in C. elegans. Aging (Albany NY) 6(11): 975-991.
  16. Chatterjee, D., Katewa, S. D., Qi, Y., Jackson, S. A., Kapahi, P. and Jasper, H. (2014). Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Proc Natl Acad Sci U S A 111(50): 17959-17964.
  17. Lin, Y. H., Chen, Y. C., Kao, T. Y., Lin, Y. C., Hsu, T. E., Wu, Y. C., Ja, W. W., Brummel, T. J., Kapahi, P., Yuh, C. H., Yu, L. K., Lin, Z. H., You, R. J., Jhong, Y. T. and Wang, H. D. (2014). Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Aging Cell 13(4): 755-764.
  18. Kaul, T. K., Reis Rodrigues, P., Ogungbe, I. V., Kapahi, P. and Gill, M. S. (2014). Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans. PLoS One 9(1): e86979.
  19. Chen, D., Li, P. W., Goldstein, B. A., Cai, W., Thomas, E. L., Chen, F., Hubbard, A. E., Melov, S. and Kapahi, P. (2013). Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep 5(6): 1600-1610.
  20. Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., Li, P., Cheng, H. L., Murphy, A. J., Valenzuela, D. M., Luo, H., Kapahi, P., Krauss, R., Mostoslavsky, R., Yancopoulos, G. D., Alt, F. W., Chua, K. F. and Chen, D. (2013). SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep 5(3): 654-665.
  21. Flynn, J. M., O'Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B. J., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., Kapahi, P., Nelson, M. D., Kennedy, B. K. and Melov, S. (2013). Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell 12(5): 851-862.
  22. Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H. D., Karayan, P., He, S., Brummel, T., Kapahi, P. and Ja, W. W. (2013). High carbohydrate-low protein consumption maximizes Drosophila lifespan. Exp Gerontol 48(10): 1129-1135.
  23. Blaschko, S. D., Chi, T., Miller, J., Flechner, L., Fakra, S., Kapahi, P., Kahn, A. and Stoller, M. L. (2013). Strontium substitution for calcium in lithogenesis. J Urol 189(2): 735-739.
  24. Blaschko, S. D., Miller, J., Chi, T., Flechner, L., Fakra, S., Kahn, A., Kapahi, P. and Stoller, M. L. (2013). Microcomposition of human urinary calculi using advanced imaging techniques. J Urol 189(2): 726-734.
  25. Katewa, S. D., Demontis, F., Kolipinski, M., Hubbard, A., Gill, M. S., Perrimon, N., Melov, S. and Kapahi, P. (2012). Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab 16(1): 97-103.
  26. Laberge, R. M., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L., Liu, S., Demaria, M., Cong, Y. S., Kapahi, P., Desprez, P. Y., Hughes, R. E. and Campisi, J. (2012). Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell 11(4): 569-578.
  27. Cai, W. J., Huang, J. H., Zhang, S. Q., Wu, B., Kapahi, P., Zhang, X. M. and Shen, Z. Y. (2011). Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6(12): e28835.
  28. Rogers, A. N., Chen, D., McColl, G., Czerwieniec, G., Felkey, K., Gibson, B. W., Hubbard, A., Melov, S., Lithgow, G. J. and Kapahi, P. (2011). Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab 14(1): 55-66.
  29. McColl, G., Rogers, A. N., Alavez, S., Hubbard, A. E., Melov, S., Link, C. D., Bush, A. I., Kapahi, P. and Lithgow, G. J. (2010). Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab 12(3): 260-272.
  30. Vargas, M. A., Luo, N., Yamaguchi, A. and Kapahi, P. (2010). A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster. Curr Biol 20(11): 1006-1011.
  31. Garcia, A. M., Calder, R. B., Dolle, M. E., Lundell, M., Kapahi, P. and Vijg, J. (2010). Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. PLoS Genet 6(5): e1000950.
  32. Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M. C., Lu, T. A., Benzer, S. and Kapahi, P. (2009). 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139(1): 149-160.
  33. Edman, U., Garcia, A. M., Busuttil, R. A., Sorensen, D., Lundell, M., Kapahi, P. and Vijg, J. (2009). Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell 8(3): 331-338.
  34. Chen, D., Thomas, E. L. and Kapahi, P. (2009).HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 5(5): e1000486.
  35. Bell, R., Hubbard, A., Chettier, R., Chen, D., Miller, J. P., Kapahi, P., Tarnopolsky, M., Sahasrabuhde, S., Melov, S. and Hughes, R. E. (2009). A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet 5(3): e1000414.
  36. Yun, J., Cao, J. H., Dodson, M. W., Clark, I. E., Kapahi, P., Chowdhury, R. B. and Guo, M. (2008). Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci 28(53): 14500-14510.
  37. Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J. and Kapahi, P. (2007). Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6(1): 111-119.
  38. Chen, D., Pan, K. Z., Palter, J. E. and Kapahi, P. (2007).Longevity determined by developmental arrest genes in Caenorhabditis elegans.Aging Cell 6(4): 525-533.
  39. Carvalho, G. B., Kapahi, P., Anderson, D. J. and Benzer, S. (2006). Allocrine modulation of feeding behavior by the sex peptide of Drosophila. Curr Biol 16(7): 692-696.
  40. Carvalho, G. B., Kapahi, P. and Benzer, S. (2005). Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat Methods 2(11): 813-815.
  41. Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. and Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14(10): 885-890.
  42. Seroude, L., Brummel, T., Kapahi, P. and Benzer, S. (2002). Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell 1(1): 47-56.
  43. Ojo-Amaize, E. A., Kapahi, P., Kakkanaiah, V. N., Takahashi, T., Shalom-Barak, T., Cottam, H. B., Adesomoju, A. A., Nchekwube, E. J., Oyemade, O. A., Karin, M. and Okogun, J. I. (2001). Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol 209(2): 149-157.
  44. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M. and Santoro, M. G. (2000). Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403(6765): 103-108.
  45. Kapahi, P., Takahashi, T., Natoli, G., Adams, S. R., Chen, Y., Tsien, R. Y. and Karin, M. (2000). Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275(46): 36062-36066.
  46. Kapahi, P., Boulton, M. E. and Kirkwood, T. B. (1999). Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med 26(5-6): 495-500.
  47. Lebranchu, Y., al Najjar, A., Kapahi, P., Valentin, J. F., Nivet, H., Bagros, P., Bardos, P. and Haskard, D. (1995). The association of increased soluble VCAM-1 levels with CMV disease in human kidney allograft recipients. Transplant Proc 27(1): 960.
  48. Groves, R. W., Kapahi, P., Barker, J. N., Haskard, D. O. and MacDonald, D. M. (1995). Detection of circulating adhesion molecules in erythrodermic skin disease. J Am Acad Dermatol 32(1): 32-36.
  49. Lebranchu, Y., Kapahi, P., al Najjar, A., Sharobeem, R., Valentin, J. F., Nivet, H., Bagros, P. and Haskard, D. (1994). Soluble e-selectin, ICAM-1, and VCAM-1 levels in renal allograft recipients. Transplant Proc 26(4): 1873-1874.
  50. Montefort, S., Lai, C. K., Kapahi, P., Leung, J., Lai, K. N., Chan, H. S., Haskard, D. O., Howarth, P. H. and Holgate, S. T. (1994). Circulating adhesion molecules in asthma. Am J Respir Crit Care Med 149(5): 1149-1152.