Education

PhD, University of Ottawa, 2013

Lab information

The Scott McComb lab focuses on research into chimeric antigen receptor T cells (CAR-T), genome editing (CRISPR and other technologies), and the mechanisms of cell death. CAR-T is an exciting new avenue to redirect immune cells to target and kill cancer. While breakthroughs in CAR-T therapy have led to life-saving treatments for patients with previously incurable leukemia, such therapies have been less successful against solid tumours. Moreover, the determinants of long term cancer regression in CAR-T treated patients are not yet well understood. Using genome editing, we are dissecting the mechanisms of programmed cell death and other immune signalling pathways in T cells in order to improve their effectiveness against cancer.

Research focus

CAR-T, cancer immunology, cell death

Publications

https://scholar.google.ca/citations?user=rAAIAKwAAAAJ&hl=en

https://pubmed.ncbi.nlm.nih.gov/31392262/
https://pubmed.ncbi.nlm.nih.gov/33616439/
https://pubmed.ncbi.nlm.nih.gov/32083149/
https://www.biorxiv.org/content/10.1101/2020.10.30.360925v2