Education

Ph.D, UCLA, USA, 1993

Current position

Professor, Neuroscience, Brown University, USA

Publications (since 2010)

1. Sorkac, A., Alcantara, I. C. and Hart, A. C. (2016). In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects. PLoS One 11(12): e0167963.
2. Dimitriadi, M., Derdowski, A., Kalloo, G., Maginnis, M. S., O'Hern, P., Bliska, B., Sorkac, A., Nguyen, K. C., Cook, S. J., Poulogiannis, G., Atwood, W. J., Hall, D. H. and Hart, A. C. (2016). Decreased function of survival motor neuron protein impairs endocytic pathways. Proc Natl Acad Sci U S A 113(30): E4377-4386.
3. Fry, A. L., Laboy, J. T., Huang, H., Hart, A. C. and Norman, K. R. (2016). A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans. Genetics 202(3): 1153-1166.
4. Anderson, E. N., Corkins, M. E., Li, J. C., Singh, K., Parsons, S., Tucey, T. M., Sorkac, A., Huang, H., Dimitriadi, M., Sinclair, D. A. and Hart, A. C. (2016). C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mech Ageing Dev 154: 30-42.
5. Moroz, N., Carmona, J. J., Anderson, E., Hart, A. C., Sinclair, D. A. and Blackwell, T. K. (2014). Dietary restriction involves NAD(+) -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell 13(6): 1075-1085.
6. Singh, K., Ju, J. Y., Walsh, M. B., DiIorio, M. A. and Hart, A. C. (2014). Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep 37(9): 1439-1451.
7. Chalfie, M., Hart, A. C., Rankin, C. H. and Goodman, M. B. (2014). Assaying mechanosensation. WormBook.
8. Sen, A., Dimlich, D. N., Guruharsha, K. G., Kankel, M. W., Hori, K., Yokokura, T., Brachat, S., Richardson, D., Loureiro, J., Sivasankaran, R., Curtis, D., Davidow, L. S., Rubin, L. L., Hart, A. C., Van Vactor, D. and Artavanis-Tsakonas, S. (2013). Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A 110(26): E2371-2380.
9. Kwon, D. Y., Dimitriadi, M., Terzic, B., Cable, C., Hart, A. C., Chitnis, A., Fischbeck, K. H. and Burnett, B. G. (2013). The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Mol Biol Cell 24(12): 1863-1871.
10. Dimitriadi, M., Kye, M. J., Kalloo, G., Yersak, J. M., Sahin, M. and Hart, A. C. (2013). The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. J Neurosci 33(15): 6557-6562.
11. Singh, K., Huang, H. and Hart, A. C. (2013). Do C. elegans sleep? A closer look. Sleep 36(3): 307-308.
12. Walker, A. K., Jacobs, R. L., Watts, J. L., Rottiers, V., Jiang, K., Finnegan, D. M., Shioda, T., Hansen, M., Yang, F., Niebergall, L. J., Vance, D. E., Tzoneva, M., Hart, A. C. and Naar, A. M. (2011). A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147(4): 840-852.
13. Liu-Yesucevitz, L., Bassell, G. J., Gitler, A. D., Hart, A. C., Klann, E., Richter, J. D., Warren, S. T. and Wolozin, B. (2011). Local RNA translation at the synapse and in disease. J Neurosci 31(45): 16086-16093.
14. Singh, K., Chao, M. Y., Somers, G. A., Komatsu, H., Corkins, M. E., Larkins-Ford, J., Tucey, T., Dionne, H. M., Walsh, M. B., Beaumont, E. K., Hart, D. P., Lockery, S. R. and Hart, A. C. (2011). C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence. Curr Biol 21(10): 825-834.
15. Hyde, R., Corkins, M. E., Somers, G. A. and Hart, A. C. (2011). PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes Brain Behav 10(3): 286-298.
16. Dimitriadi, M., Sleigh, J. N., Walker, A., Chang, H. C., Sen, A., Kalloo, G., Harris, J., Barsby, T., Walsh, M. B., Satterlee, J. S., Li, C., Van Vactor, D., Artavanis-Tsakonas, S. and Hart, A. C. (2010). Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet 6(10): e1001172.
17. Dimitriadi, M. and Hart, A. C. (2010). Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiol Dis 40(1): 4-11.
18. Haspel, G., O'Donovan, M. J. and Hart, A. C. (2010). Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans. J Neurosci 30(33): 11151-11156.
19. Walker, A. K., Yang, F., Jiang, K., Ji, J. Y., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S., Smith, J. J., Israelian, K., Westphal, C. H., Rodgers, J. T., Shioda, T., Elson, S. L., Mulligan, P., Najafi-Shoushtari, H., Black, J. C., Thakur, J. K., Kadyk, L. C., Whetstine, J. R., Mostoslavsky, R., Puigserver, P., Li, X., Dyson, N. J., Hart, A. C. and Naar, A. M. (2010). Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24(13): 1403-1417.
20. Hart, A. C. and Chao, M. Y. (2010). From Odors to Behaviors in Caenorhabditis elegans. In: Menini, A. (Ed). The Neurobiology of Olfaction. Frontiers in Neuroscience. Boca Raton (FL): CRC Press/Taylor & Francis.