Education

Ph.D. in Medical Science, Medical School, University of Debrecen, Hungary, Summa cum laude

Current Position

Lecturer in Biochemistry, Discipline of Biochemistry, Apoptosis Research Centre, National University of Ireland, Galway

Publications (sicne  2010)

1. E, O. R., Tirincsi, A., Logue, S. E. and Szegezdi, E. (2016). The Janus Face of Death Receptor Signaling during Tumor Immunoediting. Front Immunol 7: 446.
2. Dhami, S. P., Kappala, S. S., Thompson, A. and Szegezdi, E. (2016). Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing. Drug Discov Today 21(9): 1464-1471.
3. Shologu, N., Szegezdi, E., Lowery, A., Kerin, M., Pandit, A. and Zeugolis, D. I. (2016). Recreating complex pathophysiologies in vitro with extracellular matrix surrogates for anticancer therapeutics screening. Drug Discov Today 21(9): 1521-1531.
4. Nathwani, S. M., Greene, L. M., Butini, S., Campiani, G., Williams, D. C., Samali, A., Szegezdi, E. and Zisterer, D. M. (2016). The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAILinduced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells. Int J Oncol 49(1): 74-88.
5. Sass, M., Sato, K., Sato, M., Schapira, A. H., Scharl, M., Schatzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schuller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Stralfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takacs-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, L. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tonges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M., Van den Berghe, G., van der Klei, I. J., van Doorn, W., van Dyk, L. F., van Egmond, M., van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y., Yang, W., Yang, W. Y., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zakeri, Z., Zeh, H. J., 3rd, Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. and Zuckerbraun, B. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4): 445-544.
6. Szegezdi, E. and Leverkus, M. (2016). Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma. J Invest Dermatol 136(2): 362-364.
7. Chonghaile, T. N., Gupta, S., John, M., Szegezdi, E., Logue, S. E. and Samali, A. (2015). BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1. Biochem Biophys Res Commun 466(1): 40-45.
8. Healy, S., O'Leary, L. and Szegezdi, E. (2015). An added dimension to tumour TRAIL sensitivity. Oncoscience 2(11): 906-907.
9. O'Leary, L., van der Sloot, A. M., Reis, C. R., Deegan, S., Ryan, A. E., Dhami, S. P., Murillo, L. S., Cool, R. H., Correa de Sampaio, P., Thompson, K., Murphy, G., Quax, W. J., Serrano, L., Samali, A. and Szegezdi, E. (2016). Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. Oncogene 35(10): 1261-1270.
10. O’ Reilly, E., Santocanale, C. and Szegezdi, E. (2015). Molecular targets for novel drug development in pancreatic cancer. Annals of Cancer Research. 2: 3.
11. Cruet-Hennequart, S., Paavilainen, T., O’Dwyer, M., Tóth, R., Carty, P. M., Samali, A. and Szegezdi, E. (2015). G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis. J Leukemia 3: 174.
12. Zhou, J., Reidy, M., O'Reilly, C., Jarikote, D. V., Negi, A., Samali, A., Szegezdi, E. and Murphy, P. V. (2015). Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor. Org Lett 17(7): 1672-1675.
13. O'Reilly, P., Ortutay, C., Gernon, G., O'Connell, E., Seoighe, C., Boyce, S., Serrano, L. and Szegezdi, E. (2014). Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy. BMC Genomics 15: 1144.
14. Baev, D. V., Krawczyk, J., M, O. D. and Szegezdi, E. (2014). The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells. Leuk Res Rep 3(2): 79-82.
15. Sessler, T., Healy, S., Samali, A. and Szegezdi, E. (2013). Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling. Pharmacol Ther 140(2): 186-199.
16. van Dijk, M., Halpin-McCormick, A., Sessler, T., Samali, A. and Szegezdi, E. (2013). Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways. Cell Death Dis. 4:e702.
17. Leanza, L., O'Reilly, P., Doyle, A., Venturini, E., Zoratti, M., Szegezdi, E. and Szabo, I. (2014). Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines. Curr Pharm Des 20(2): 189-200.
18. Gupta, S., Giricz, Z., Natoni, A., Donnelly, N., Deegan, S., Szegezdi, E. and Samali, A. (2012). NOXA contributes to the sensitivity of PERK-deficient cells to ER stress. FEBS Lett 586(22): 4023-4030.
19. Szegezdi, E., van der Sloot, A. M., Mahalingam, D., O'Leary, L., Cool, R. H., Munoz, I. G., Montoya, G., Quax, W. J., de Jong, S., Samali, A. and Serrano, L. (2012). Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL. Mol Cell Proteomics 11(3): M111 013730.
20. Dijk, M., Murphy, E., Morrell, R., Knapper, S., O'Dwyer, M., Samali, A. and Szegezdi, E. (2011). The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis. Cancers (Basel) 3(1): 1329-1350.
21. Foley, S. A., Szegezdi, E., Mulloy, B., Samali, A. and Tuohy, M. G. (2011). An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro. J Nat Prod 74(9): 1851-1861.
22. Mahalingam, D., Oldenhuis, C. N., Szegezdi, E., Giles, F. J., de Vries, E. G., de Jong, S. and Nawrocki, S. T. (2011). Targeting TRAIL towards the clinic. Curr Drug Targets 12(14): 2079-2090.
23. Reis, C. R., van der Sloot, A. M., Natoni, A., Szegezdi, E., Setroikromo, R., Meijer, M., Sjollema, K., Stricher, F., Cool, R. H., Samali, A., Serrano, L. and Quax, W. J. (2010). Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants. Cell Death Dis 1: e83.
24. Vrielink, J., Heins, M. S., Setroikromo, R., Szegezdi, E., Mullally, M. M., Samali, A. and Quax, W. J. (2010). Synthetic constrained peptide selectively binds and antagonizes death receptor 5. FEBS J 277(7): 1653-1665.
25. Gupta, S., Cuffe, L., Szegezdi, E., Logue, S. E., Neary, C., Healy, S. and Samali, A. (2010). Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization. Int J Cell Biol 2010: 170215.
26. Szegezdi, E., Reis, C. R., van der Sloot, A. M., Natoni, A., O'Reilly, A., Reeve, J., Cool, R. H., O'Dwyer, M., Knapper, S., Serrano, L., Quax, W. J. and Samali, A. (2011). Targeting AML through DR4 with a novel variant of rhTRAIL. J Cell Mol Med 15(10): 2216-2231.