Education

Ph.D in Biochemistry, University Denis Diderot Paris VII, Paris, France, 1996

Current Position

Institut de Recherche Interdisciplinaire en Biologie Humaine Moléculaire, Université Libre de Bruxelles, Belgium

Publications

1. Fernandez Vallone, V. and Garcia, M. I. (2016). Stem Cells in Adult Homeostasis, Regeneration and Tissue Development of the Digestive Tract Epithelium. International Journal of Stem Cell Research & Therapy 3(2): 038.
2. Fernandez Vallone, V., Leprovots, M., Strollo, S., Vasile, G., Lefort, A., Libert, F., Vassart, G. and Garcia, M. I. (2016). Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage. Development 143(9): 1452-1463.
3. Zak, M., van Oort, T., Hendriksen, F. G., Garcia, M. I., Vassart, G. and Grolman, W. (2016). LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci 10: 186.
4. Garcia, M. I. and Vassart, G. (2014). Identification des progéniteurs de l’épithélium intestinal foetal. Med Sci (Paris) 30(4): 353-355.
5. Garcia, M. I., Fernandez Vallone, V. and Vassart, G. (2014). Discovery and characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors. In: Stevens, C. W. (ed). The Genetics of G Protein‐Coupled Receptors: Methods for the Post‐Genomic Era.
6. Mustata, R. C., Vasile, G., Fernandez-Vallone, V., Strollo, S., Lefort, A., Libert, F., Monteyne, D., Perez-Morga, D., Vassart, G. and Garcia, M. I. (2013). Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium. Cell Rep 5(2): 421-432.
7. Mustata, R. C., Van Loy, T., Lefort, A., Libert, F., Strollo, S., Vassart, G. and Garcia, M. I. (2011). Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep 12(6): 558-564.
8. Garcia, M. I., Ghiani, M., Lefort, A., Libert, F., Strollo, S. and Vassart, G. (2009). LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol 331(1): 58-67.
9. Caruso, M., Busanello, A., Sthandier, O., Cavaldesi, M., Gentile, M., Garcia, M. I. and Amati, P. (2007). Mutation in the VP1-LDV motif of the murine polyomavirus affects viral infectivity and conditions virus tissue tropism in vivo. J Mol Biol 367(1): 54-64.
10. Carbone, M., Reale, A., Di Sauro, A., Sthandier, O., Garcia, M. I., Maione, R., Caiafa, P. and Amati, P. (2006). PARP-1 interaction with VP1 capsid protein regulates polyomavirus early gene expression. J Mol Biol 363(4): 773-785.
11. Cavaldesi, M., Caruso, M., Sthandier, O., Amati, P. and Garcia, M. I. (2004). Conformational changes of murine polyomavirus capsid proteins induced by sialic acid binding. J Biol Chem 279(40): 41573-41579.
12. Carbone, M., Ascione, G., Chichiarelli, S., Garcia, M. I., Eufemi, M. and Amati, P. (2004). Chromosome-protein interactions in polyomavirus virions. J Virol 78(1): 513-519.
13. Caruso, M., Cavaldesi, M., Gentile, M., Sthandier, O., Amati, P. and Garcia, M. I. (2003). Role of sialic acid-containing molecules and the alpha4beta1 integrin receptor in the early steps of polyomavirus infection. J Gen Virol 84(Pt 11): 2927-2936.
14. Caruso, M., Belloni, L., Sthandier, O., Amati, P. and Garcia, M. I.  (2003). α4β1 Integrin Acts as a Cell Receptor for Murine Polyomavirus at the Postattachment Level. J Virol 77: 3913-3921. 
15. Heidari, S., Vlastos, A., Ramqvist, T., Clark, B., Griffin, B. E., Garcia, M. I., Perez, M., Amati, P. and Dalianis, T. (2002). Immunization of T-cell deficient mice against polyomavirus infection using viral pseudocapsids or temperature sensitive mutants. Vaccine 20(11-12): 1571-1578.
16. Garcia, M. I., Perez, M., Caruso, M., Sthandier, O., Ferreira, R., Cermola, M., Macchia, C. and Amati, P. (2000). A mutation in the DE loop of the VP1 protein that prevents polyomavirus transcription and replication. Virology 272(2): 293-301.
17. Le Bouguenec, C., Lalioui, L., du Merle, L., Jouve, M., Courcoux, P., Bouzari, S., Selvarangan, R., Nowicki, B. J., Germani, Y., Andremont, A., Gounon, P. and Garcia, M. I. (2001). Characterization of AfaE adhesins produced by extraintestinal and intestinal human Escherichia coli isolates: PCR assays for detection of Afa adhesins that do or do not recognize Dr blood group antigens. J Clin Microbiol 39(5): 1738-1745.
18. Garcia, M. I., Jouve, M., Nataro, J. P., Gounon, P. and Le Bouguenec, C. (2000). Characterization of the AfaD-like family of invasins encoded by pathogenic Escherichia coli associated with intestinal and extra-intestinal infections. FEBS Lett 479(3): 111-117.
19. Garcia, M. I., Perez, M., Caruso, M., Sthandier, O., Ferreira, R., Cermola, M., Macchia, C. and Amati, P. (2000). A mutation in the DE loop of the VP1 protein that prevents polyomavirus transcription and replication. Virology 272(2): 293-301.
20. Pierard, D. and Lauwers, S. (1998). Enteric infections due to Escherichia coli. Clin Microbiol Infect 4(7): 414-415.
21. Jouve, M., Garcia, M. I., Courcoux, P., Labigne, A., Gounon, P. and Le Bouguenec, C. (1997). Adhesion to and invasion of HeLa cells by pathogenic Escherichia coli carrying the afa-3 gene cluster are mediated by the AfaE and AfaD proteins, respectively. Infect Immun 65(10): 4082-4089.
22. Garcia, M. I., Gounon, P., Courcoux, P., Labigne, A. and Le Bouguenec, C. (1996). The afimbrial adhesive sheath encoded by the afa-3 gene cluster of pathogenic Escherichia coli is composed of two adhesins. Mol Microbiol 19(4): 683-693.
23. Garcia, M. I. and Le Bouguenec, C. (1996). Role of adhesion in pathogenicity of human uropathogenic and diarrhoaegenic Escherichia coli. Bull Inst Pasteur 94: 201-236.
24. Garcia, M. I., Labigne, A. and Le Bouguenec, C. (1994). Nucleotide sequence of the afimbrial-adhesin-encoding afa-3 gene cluster and its translocation via flanking IS1 insertion sequences. J Bacteriol 176(24): 7601-7613.
25. Le Bouguenec, C., Garcia, M. I., Ouin, V., Desperrier, J. M., Gounon, P. and Labigne, A. (1993). Characterization of plasmid-borne afa-3 gene clusters encoding afimbrial adhesins expressed by Escherichia coli strains associated with intestinal or urinary tract infections. Infect Immun 61(12): 5106-5114.