Education

Ph.D in Biotechnology, Indian Institute of Technology Delhi, India

Current Position

Assistant Professor in the Department of Medical Microbiology and Immunology at University of Toledo College of Medicine and Life Sciences

Publications (since 2005)

1. Chakravarti, R., Sapountzi, V. and Adams, J. C. (2005). Functional role of syndecan-1 cytoplasmic V region in lamellipodial spreading, actin bundling, and cell migration. Mol Biol Cell 16(8): 3678-3691.
2. Chattopadhyay, S., Veleeparambil, M., Poddar, D., Abdulkhalek, S., Bandyopadhyay, S. K., Fensterl, V. and Sen, G. C. (2015). EGFR kinase activity is required for TLR4 signaling and the septic shock response. EMBO Rep 16(11): 1535-1547.
3. Fensterl, V., Chattopadhyay, S. and Sen, G. C. (2015). No Love Lost Between Viruses and Interferons. Annu Rev Virol 2(1): 549-572.
4. Majumdar, T., Chattopadhyay, S., Ozhegov, E., Dhar, J., Goswami, R., Sen, G. C. and Barik, S. (2015). Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLoS Pathog 11(3): e1004779.
5. Chattopadhyay, S. and Sen, G. C. (2014). Tyrosine phosphorylation in Toll-like receptor signaling. Cytokine Growth Factor Rev 25(5): 533-541.
6. Chattopadhyay, S. and Sen, G. C. (2014). Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation. Mol Cell 54(2): 210-211.
7. Chattopadhyay, S. and Sen, G. C. (2014). dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. J Interferon Cytokine Res 34(6): 427-436.
8. Chattopadhyay, S., Kessler, S. P., Colucci, J. A., Yamashita, M., Senanayake, P. and Sen, G. C. (2014). Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice. PLoS One 9(1): e87484.
9. Goswami, R., Majumdar, T., Dhar, J., Chattopadhyay, S., Bandyopadhyay, S. K., Verbovetskaya, V., Sen, G. C. and Barik, S. (2013). Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Res 23(8): 1025-1042.
10. Chattopadhyay, S., Fensterl, V., Zhang, Y., Veleeparambil, M., Wetzel, J. L. and Sen, G. C. (2013). Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators. MBio 4(2).
11. Chattopadhyay, S., Fensterl, V., Zhang, Y., Veleeparambil, M., Yamashita, M. and Sen, G. C. (2013). Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus. J Virol 87(1): 16-24.
12. Yamashita, M., Millward, C. A., Inoshita, H., Saikia, P., Chattopadhyay, S., Sen, G. C. and Emancipator, S. N. (2013). Antiviral innate immunity disturbs podocyte cell function. J Innate Immun 5(3): 231-241.
13. Chattopadhyay, S., Yamashita, M. and Sen, G. C. (2012). DsRNA-elicited antiviral actions that are not mediated by induced genes. In: Fujita, T. and Sambhara, P. (Eds). Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience: 218-239.
14. Yamashita, M., Chattopadhyay, S., Fensterl, V., Saikia, P., Wetzel, J. L. and Sen, G. C. (2012). Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal 5(233): ra50.
15. Yamashita, M., Chattopadhyay, S., Fensterl, V., Zhang, Y. and Sen, G. C. (2012). A TRIF-independent branch of TLR3 signaling. J Immunol 188(6): 2825-2833.
16. Sears, N., Sen, G. C., Stark, G. R. and Chattopadhyay, S. (2011). Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem 286(38): 33037-33044.
17. White, C. L., Chattopadhyay, S. and Sen, G. C. (2011). Phosphatidylinositol 3-kinase signaling delays sendai virus-induced apoptosis by preventing XIAP degradation. J Virol 85(10): 5224-5227.
18. Chattopadhyay, S., Yamashita, M., Zhang, Y. and Sen, G. C. (2011). The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication. J Virol 85(8): 3708-3716.
19. Zhu, J., Smith, K., Hsieh, P. N., Mburu, Y. K., Chattopadhyay, S., Sen, G. C. and Sarkar, S. N. (2010). High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors. J Immunol 184(10): 5768-5776.
20. Chattopadhyay, S., Marques, J. T., Yamashita, M., Peters, K. L., Smith, K., Desai, A., Williams, B. R. and Sen, G. C. (2010). Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J 29(10): 1762-1773.
21. Chattopadhyay, S. and Sen, G. C. (2010). IRF-3 and Bax: a deadly affair. Cell Cycle 9(13): 2479-2480.
22. Chattopadhyay, S., Karan, G., Sen, I. and Sen, G. C. (2008). A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane. Biochemistry 47(32): 8335-8341.
23. Peters, K., Chattopadhyay, S. and Sen, G. C. (2008). IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence. J Virol 82(7): 3500-3508.
24. Sarkar, S. N., Elco, C. P., Peters, K. L., Chattopadhyay, S. and Sen, G. C. (2007). Two tyrosine residues of toll-like receptor 3 trigger different steps of NF B activation. Journal of Biological Chemistry, 282(6): 3423-3427.
25. Chattopadhyay, S., Santhamma, K. R., Sengupta, S., McCue, B., Kinter, M., Sen, G. C. and Sen, I. (2005). Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem 280(40): 33847-33855.