William H. Catherino
  • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, USA
Research fields
  • Cell biology
Personal information

Education

Ph.D in Human Oncology and Pharmacolo, University of Wisconsin-Madison, Madison, WI, 1995

Current position

Professor and Acting Vice-Chair, Department of Obstetrics and Gynecology Uniformed Services University of the Health Sciences 
Director, Research Division, Department of Obstetrics and Gynecology Uniformed Services University of the Health Sciences

Publications (since 2010)

  1. Patel, A., Malik, M., Britten, J., Cox, J. and Catherino, W. H. (2016). Mifepristone inhibits extracellular matrix formation in uterine leiomyoma. Fertil Steril 105(4): 1102-1110.

  2. Protic, O., Toti, P., Islam, M. S., Occhini, R., Giannubilo, S. R., Catherino, W. H., Cinti, S., Petraglia, F., Ciavattini, A., Castellucci, M., Hinz, B. and Ciarmela, P. (2016). Possible involvement of inflammatory/reparative processes in the development of uterine fibroids. Cell Tissue Res 364(2): 415-427.

  3. Malik, M., Britten, J., Cox, J., Patel, A. and Catherino, W. H. (2016). Gonadotropin-releasing hormone analogues inhibit leiomyoma extracellular matrix despite presence of gonadal hormones. Fertil Steril 105(1): 214-224.

  4. Green, K. A., Zarek, S. M. and Catherino, W. H. (2015). Gynecologic health and disease in relation to the microbiome of the female reproductive tract. Fertil Steril 104(6): 1351-1357.

  5. Drayer, S. M. and Catherino, W. H. (2015). Prevalence, morbidity, and current medical management of uterine leiomyomas. Int J Gynaecol Obstet 131(2): 117-122.

  6. Patel, A., Malik, M., Britten, J., Cox, J. and Catherino, W. H. (2014). Alternative therapies in management of leiomyomas. Fertil Steril 102(3): 649-655.

  7. Malik, M., Britten, J., Segars, J. and Catherino, W. H. (2014). Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures. Reprod Sci 21(9): 1126-1138.

  8. Islam, M. S., Protic, O., Ciavattini, A., Giannubilo, S. R., Tranquilli, A. L., Catherino, W. H., Castellucci, M. and Ciarmela, P. (2014). Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells. Fertil Steril 102(2): 597-606.

  9. Levy, G., Malik, M., Britten, J., Gilden, M., Segars, J. and Catherino, W. H. (2014). Liarozole inhibits transforming growth factor-beta3--mediated extracellular matrix formation in human three-dimensional leiomyoma cultures. Fertil Steril 102(1): 272-281 e272.

  10. Islam, M. S., Catherino, W. H., Protic, O., Janjusevic, M., Gray, P. C., Giannubilo, S. R., Ciavattini, A., Lamanna, P., Tranquilli, A. L., Petraglia, F., Castellucci, M. and Ciarmela, P. (2014). Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function. J Clin Endocrinol Metab 99(5): E775-785.

  11. Tinelli, A., Mettler, L., Malvasi, A., Hurst, B., Catherino, W., Mynbaev, O. A., Guido, M., Alkatout, I. and Schollmeyer, T. (2014). Impact of surgical approach on blood loss during intracapsular myomectomy. Minim Invasive Ther Allied Technol 23(2): 87-95.

  12. Catherino, W. H., Eltoukhi, H. M. and Al-Hendy, A. (2013). Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma. Semin Reprod Med 31(5): 370-379.

  13. Levy, G., Hill, M. J., Plowden, T. C., Catherino, W. H. and Armstrong, A. Y. (2013). Biomarkers in uterine leiomyoma. Fertil Steril 99(4): 1146-1152.

  14. Malik, M., Segars, J. and Catherino, W. H. (2012). Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth. Matrix Biol 31(7-8): 389-397.

  15. Gilden, M., Malik, M., Britten, J., Delgado, T., Levy, G. and Catherino, W. H. (2012). Leiomyoma fibrosis inhibited by liarozole, a retinoic acid metabolic blocking agent. Fertil Steril 98(6): 1557-1562.

  16. Britten, J. L., Malik, M., Levy, G., Mendoza, M. and Catherino, W. H. (2012). Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. Fertil Steril 98(5): 1299-1307.

  17. Wellons, M. F., Fujimoto, V. Y., Baker, V. L., Barrington, D. S., Broomfield, D., Catherino, W. H., Richard-Davis, G., Ryan, M., Thornton, K. and Armstrong, A. Y. (2012). Race matters: a systematic review of racial/ethnic disparity in Society for Assisted Reproductive Technology reported outcomes. Fertil Steril 98(2): 406-409.

  18. Levy, G., Hill, M. J., Beall, S., Zarek, S. M., Segars, J. H. and Catherino, W. H. (2012). Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances. J Assist Reprod Genet 29(8): 703-712.

  19. Malik, M. and Catherino, W. H. (2012). Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium. Fertil Steril 97(6): 1287-1293.

  20. Norian, J. M., Owen, C. M., Taboas, J., Korecki, C., Tuan, R., Malik, M., Catherino, W. H. and Segars, J. H. (2012). Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol 31(1): 57-65.

  21. Catherino, W. H. (2011). Stress relief to augment fertility: the pressure mounts. Fertil Steril 95(8): 2462-2463.

  22. McCarthy-Keith, D. M., Malik, M., Britten, J., Segars, J. and Catherino, W. H. (2011). Gonadotropin-releasing hormone agonist increases expression of osmotic response genes in leiomyoma cells. Fertil Steril 95(7): 2383-2387.

  23. Catherino, W. H., Parrott, E. and Segars, J. (2011). Proceedings from theNational Institute of Child Health and Human Development conference on the Uterine Fibroid Research Update Workshop. Fertil Steril 95(1): 9-12.

  24. Catherino, W. H., Malik, M., Driggers, P., Chappel, S., Segars, J. and Davis, J. (2010). Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium. J Steroid Biochem Mol Biol 122(4): 279-286.

  25. Catherino, W. H. (2010). Insights and advances in uterine leiomyomas. Semin Reprod Med 28(3): 167-168.

  26. Malik, M., Norian, J., McCarthy-Keith, D., Britten, J. and Catherino, W. H. (2010). Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women. Semin Reprod Med 28(3): 169-179.

  27. Fujimoto, V. Y., Jain, T., Alvero, R., Nelson, L. M., Catherino, W. H., Olatinwo, M., Marsh, E. E., Broomfield, D., Taylor, H. and Armstrong, A. Y. (2010). Proceedings from the conference on Reproductive Problems in Women of Color. Fertil Steril 94(1): 7-10.

  28. Joseph, D. S., Malik, M., Nurudeen, S. and Catherino, W. H. (2010). Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3. Fertil Steril 93(5): 1500-1508.

  29. Taylor, J. E., Miller, B. T., Gray, K. D., Scott, R. T., Jr., Catherino, W. H. and Segars, J. H. (2010). The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonist. Fertil Steril 93(5): 1668-1675.

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