Education

PhD in Microbiology, Department of Microbiology and Biotechnology, University Bonn, Germany

Current position

Professor for Biochemistry and Molecular Biology, Medical Faculty, University Freiburg, Germany

Publications

1. Koch, H. G. and Schneider, D. (2016). Assembly of Transmembrane b-type Cytochromes and Cytochrome complexes. In: Cramer, W.A. and Kallas, T. (eds). Cytochrome complexes: Evolution, Structures, Energy Transduction, and Signaling, Springer, Dordrecht.

2. Khalfaoui-Hassani, B., Verissimo, A. F., Shroff, N., Ekici, S., Trasnea, P-I., Utz, M., Koch, H-G. and Daldal, F. (2016). Biogenesis of Cytochrome c Complexes: From Insertion of Redox Cofactors to Assembly of Different Subunits. In: Cramer, W. A. and Kallas, T. (eds). Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling, Advances in Photosynthesis and Respiration 41, pp. 527-554.
3. Hannemann, L., Suppanz, I., Ba, Q., MacInnes, K., Drepper, F., Warscheid, B. and Koch, H. G. (2016). Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1. Antioxid Redox Signal 24(3): 141-156.
4. Trasnea, P. I., Utz, M., Khalfaoui-Hassani, B., Lagies, S., Daldal, F. and Koch, H. G. (2016). Cooperation between two periplasmic copper chaperones is required for full activity of the cbb3 -type cytochrome c oxidase and copper homeostasis in Rhodobacter capsulatus. Mol Microbiol 100(2): 345-361.
5. Khalfaoui-Hassani, B., Verissimo, A. F., Koch, H. G. and Daldal, F. (2016). Uncovering the Transmembrane Metal Binding Site of the Novel Bacterial Major Facilitator Superfamily-Type Copper Importer CcoA. MBio 7(1): e01981-01915.
6. Petriman, N. A., Jauß, B. and Koch, H. G. (2015). Proteintransport in Bakterien: Einblicke in die Funktionsweise komplexer Transportmaschinerien. Biospektrum 7,696-698.
7. Kuhn, P., Draycheva, A., Vogt, A., Petriman, N. A., Sturm, L., Drepper, F., Warscheid, B., Wintermeyer, W. and Koch, H. G. (2015). Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon. J Cell Biol 211(1): 91-104.
8. Denks, K., Vogt, A., Sachelaru, I., Petriman, N. A., Kudva, R. and Koch, H. G. (2014). The Sec translocon mediated protein transport in prokaryotes and eukaryotes. Mol Membr Biol 31(2-3): 58-84.
9. Sachelaru, I., Petriman, N. A., Kudva, R. and Koch, H. G. (2014). Dynamic interaction of the sec translocon with the chaperone PpiD. J Biol Chem 289(31): 21706-21715.
10. Kuhn, P., Kudva, R., Welte, T., Sturm, L. and Koch, H. G. (2014). Targeting and integration of bacterial membrane proteins. In: Remaut, H. and Fronzes, R. (eds). Bacterial Membranes: Structural and Molecular Biology, Horizon Press,  Norwich, U. K.
11. Braig, D., Kaiser, B., Thiele, J. R., Bannasch, H., Peter, K., Stark, G. B., Koch, H. G. and Eisenhardt, S. U. (2014). A conformational change of C-reactive protein in burn wounds unmasks its proinflammatory properties. Int Immunol 26(8): 467-478.
12. Ekici, S., Turkarslan, S., Pawlik, G., Dancis, A., Baliga, N. S., Koch, H. G. and Daldal, F. (2014). Intracytoplasmic copper homeostasis controls cytochrome c oxidase production. MBio 5(1): e01055-01013.
13. Sachelaru, I., Petriman, N. A., Kudva, R., Kuhn, P., Welte, T., Knapp, B., Drepper, F., Warscheid, B. and Koch, H. G. (2013). YidC occupies the lateral gate of the SecYEG translocon and is sequentially displaced by a nascent membrane protein. J Biol Chem 288(23): 16295-16307.
14. Koch, H. G. (2013). Keine Pause bei Prolinen: Wie der Elongationsfaktor EF-P die Proteinsynthese rettet. Biospektrum 3, 13.
15. Kudva, R., Denks, K., Kuhn, P., Vogt, A., Muller, M. and Koch, H. G. (2013). Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways. Res Microbiol 164(6): 505-534.
16. Ekici, S., Jiang, X., Koch, H. G. and Daldal, F. (2013). Missense mutations in cytochrome c maturation genes provide new insights into Rhodobacter capsulatus cbb3-type cytochrome c oxidase biogenesis. J Bacteriol 195(2): 261-269.
17. Wenk, M., Ba, Q., Erichsen, V., MacInnes, K., Wiese, H., Warscheid, B. and Koch, H. G. (2012). A universally conserved ATPase regulates the oxidative stress response in Escherichia coli. J Biol Chem 287(52): 43585-43598.
18. Eikici, S., Pawlik, G., Lohmeyer, E., Koch, H. G. and Daldal, F. (2012). Biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus. Biochim. Biophys. Acta, 1817, 898-910.
19. Lohmeyer, E., Schroder, S., Pawlik, G., Trasnea, P. I., Peters, A., Daldal, F. and Koch, H. G. (2012). The ScoI homologue SenC is a copper binding protein that interacts directly with the cbb(3)-type cytochrome oxidase in Rhodobacter capsulatus. Biochim Biophys Acta 1817(11): 2005-2015.
20. Ekici, S., Yang, H., Koch, H. G. and Daldal, F. (2012). Novel transporter required for biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus. MBio 3(1)
21. Welte, T., Kudva, R., Kuhn, P., Sturm, L., Braig, D., Muller, M., Warscheid, B., Drepper, F. and Koch, H. G. (2012). Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle. Mol Biol Cell 23(3): 464-479.
22. Braig, D., Mircheva, M., Sachelaru, I., van der Sluis, E. O., Sturm, L., Beckmann, R. and Koch, H. G. (2011). Signal sequence-independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle. Mol Biol Cell 22(13): 2309-2323.
23. Kuhn, P., Weiche, B., Sturm, L., Sommer, E., Drepper, F., Warscheid, B., Sourjik, V. and Koch, H. G. (2011). The bacterial SRP receptor, SecA and the ribosome use overlapping binding sites on the SecY translocon. Traffic 12(5): 563-578.
24. Pawlik, G., Kulajta, C., Sachelaru, I., Schroder, S., Waidner, B., Hellwig, P., Daldal, F. and Koch, H. G. (2010). The putative assembly factor CcoH is stably associated with the cbb3-type cytochrome oxidase. J Bacteriol 192(24): 6378-6389.
25. Mircheva, M., Boy, D., Weiche, B., Hucke, F., Graumann, P. and Koch, H. G. (2009). Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor. BMC Biol 7: 76.
26. Burk, J., Weiche, B., Wenk, M., Boy, D., Nestel, S., Heimrich, B. and Koch, H. G. (2009). Depletion of the signal recognition particle receptor inactivates ribosomes in Escherichia coli. J Bacteriol 191(22): 7017-7026.
27. Braig, D., Bar, C., Thumfart, J. O. and Koch, H. G. (2009). Two cooperating helices constitute the lipid-binding domain of the bacterial SRP receptor. J Mol Biol 390(3): 401-413.
28. Boy, D. and Koch, H. G. (2009). Visualization of distinct entities of the SecYEG translocon during translocation and integration of bacterial proteins. Mol Biol Cell 20(6): 1804-1815.
29. Sanders, C., Turkasalan, S., Onder, O., Frawley, E. R., Kranz, R. G., Koch, H. G. and Daldal, F. (2008). Biogenesis of cytochromes and cytochrome complexes. In: Hunter, C. N., Daldal, F., Thurnauer, M. C. and Beatty, J. T. (eds). The Purple Phototrophic Bacteria., Springer Verlag, Heidelberg.
30. Peters, A., Kulajta, C., Pawlik, G., Daldal, F. and Koch, H. G. (2008). Stability of the cbb3-type cytochrome oxidase requires specific CcoQ-CcoP interactions. J Bacteriol 190(16): 5576-5586.
31. Weiche, B., Burk, J., Angelini, S., Schiltz, E., Thumfart, J. O. and Koch, H. G. (2008). A cleavable N-terminal membrane anchor is involved in membrane binding of the Escherichia coli SRP receptor. J Mol Biol 377(3): 761-773.
32. Angelini, S., Boy, D., Schiltz, E. and Koch, H. G. (2006). Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites. J Cell Biol 174(5): 715-724.
33. Koch, H. G. und Schneider, D. (2007). Folding, assembly and stability of transmembrane cytochromes. Current Chemical Biology 1; 59-74.
34. Aygun-Sunar, S., Mandaci, S., Koch, H. G., Murray, I. V., Goldfine, H. and Daldal, F. (2006). Ornithine lipid is required for optimal steady-state amounts of c-type cytochromes in Rhodobacter capsulatus. Mol Microbiol 61(2): 418-435.
35. Kulajta, C., Thumfart, J. O., Haid, S., Daldal, F. and Koch, H. G. (2006). Multi-step assembly pathway of the cbb3-type cytochrome c oxidase complex. J Mol Biol 355(5): 989-1004.
36. Deitermann, S., Sprie, G. S. and Koch, H. G. (2005). A dual function for SecA in the assembly of single spanning membrane proteins in Escherichia coli. J Biol Chem 280(47): 39077-39085.
37. Angelini, S., Deitermann, S. and Koch, H. G. (2005). FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep 6(5): 476-481.