Education

Ph.D. in Cell Biology, University of Coimbra, Coimbra, Portugal

Current position

Associate Professor, Center for Neuroscience and Cell Biology and Department of Life Sciences, University of Coimbra, Coimbra, Portugal

Publications (Selected)

1. Mele, M., Aspromonte, M. C. and Duarte, C. B. (2016). Downregulation of GABA Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia. Mol Neurobiol.
   
2. Costa, J. T., Mele, M., Baptista, M. S., Gomes, J. R., Ruscher, K., Nobre, R. J., de Almeida, L. P., Wieloch, T. and Duarte, C. B. (2015). Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABA Receptor Clustering and Contributes to Neuronal Death. Mol Neurobiol.
   
3. Curcio, M., Salazar, I. L., Inacio, A. R., Duarte, E. P., Canzoniero, L. M. and Duarte, C. B. (2015). Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis 6: e1645.
   
4. Santos, A. R., Mele, M., Vaz, S. H., Kellermayer, B., Grimaldi, M., Colino-Oliveira, M., Rombo, D. M., Comprido, D., Sebastiao, A. M. and Duarte, C. B. (2015). Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci 35(8): 3319-3329.
   
5. Mele, M., Ribeiro, L., Inacio, A. R., Wieloch, T. and Duarte, C. B. (2014). GABA(A) receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia. Neurobiol Dis 65: 220-232.
   
6. Leal, G., Comprido, D. and Duarte, C. B. (2014). BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology 76 Pt C: 639-656.
   
7. Caldeira, M. V., Curcio, M., Leal, G., Salazar, I. L., Mele, M., Santos, A. R., Melo, C. V., Pereira, P., Canzoniero, L. M. and Duarte, C. B. (2013). Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons. Biochim Biophys Acta 1832(1): 263-274.
   
8. Gomes, J. R., Costa, J. T., Melo, C. V., Felizzi, F., Monteiro, P., Pinto, M. J., Inacio, A. R., Wieloch, T., Almeida, R. D., Graos, M. and Duarte, C. B. (2012). Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. J Neurosci 32(13): 4610-4622.
   
9. Gomes, J. R., Lobo, A. C., Melo, C. V., Inacio, A. R., Takano, J., Iwata, N., Saido, T. C., de Almeida, L. P., Wieloch, T. and Duarte, C. B. (2011). Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. J Neurosci 31(12): 4622-4635.
   
10. Lobo, A. C., Gomes, J. R., Catarino, T., Mele, M., Fernandez, P., Inacio, A. R., Bahr, B. A., Santos, A. E., Wieloch, T., Carvalho, A. L. and Duarte, C. B. (2011). Cleavage of the vesicular glutamate transporters under excitotoxic conditions. Neurobiol Dis 44(3): 292-303.
    
11. Manadas, B., Santos, A. R., Szabadfi, K., Gomes, J. R., Garbis, S. D., Fountoulakis, M. and Duarte, C. B. (2009). BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. J Proteome Res 8(10): 4536-4552.
    
12. Caldeira, M. V., Melo, C. V., Pereira, D. B., Carvalho, R., Correia, S. S., Backos, D. S., Carvalho, A. L., Esteban, J. A. and Duarte, C. B. (2007). Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons. J Biol Chem 282(17): 12619-12628.    
    
13. Caldeira, M. V., Melo, C. V., Pereira, D. B., Carvalho, R. F., Carvalho, A. L. and Duarte, C. B. (2007). BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Mol Cell Neurosci 35(2): 208-219.
    
14. Almeida, R. D., Manadas, B. J., Melo, C. V., Gomes, J. R., Mendes, C. S., Graos, M. M., Carvalho, R. F., Carvalho, A. P. and Duarte, C. B. (2005). Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ 12(10): 1329-1343.
    
15. https://orcid.org/0000-0002-1474-0208