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Francisco Martín

Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalucian Regional Government, PTS Granada, Spain

Personal information

Education

Ph.D. in Biologia molecular, Universidad de Granada, Granada, Andalusia, Spain, 1994

Current position

Team Leader, Department of human genetic variability, GENYO (since 2009)

Publications

  1. Carrillo-Gálvez, A. B., Cobo, M., Cuevas-Ocaña, S., Gutiérrez-Guerrero, A., Sánchez-Gilabert, A., Bongarzone, P., Garcia-Perez, A., Muñoz, P., Benabdellah, K., Toscano, M. G., Martín, F. and Anderson, P. (2015). Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells 33(1): 183-195.
  2. Toscano, M. G., Navarro-Montero, O., Ayllon, V., Ramos-Mejia, V., Guerrero-Carreno, X., Bueno, C., Romero, T., Lamolda, M., Cobo, M., Martin, F.*, Menendez, P.* and Real, P. J.* (2015). SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Mol Ther 23(1): 158-170.
  3. Toscano, M. G., Navarro-Montero, O., Ayllon, V., Ramos-Mejia, V., Guerrero-Carreno, X., Bueno, C., Romero, T., Lamolda, M., Cobo, M., Martin, F.*, Menendez, P.* and Real, P. J.* (2015). SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Mol Ther 23(1): 158-170. *Share senior authorship.
  4. Benabdellah, K., Gutierrez-Guerrero, A., Cobo, M., Muñoz, P. and Martín, F. (2014). A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells. PLoS One 9(1): e84268.
  5. Muñoz-Fernández, R., Prados, A., Tirado-González, I., Martín, F., Abadía, A. C. and Olivares, E. G. (2014). Contractile activity of human follicular dendritic cells. Immunol Cell Biol 92(10): 851-859.
  6. Hernández-Cortés, P., Toledo-Romero, M. A., Delgado, M., Sánchez-González, C. E., Martin, F., Galindo-Moreno, P. and O'Valle, F. (2014). Peripheral nerve reconstruction with epsilon-caprolactone conduits seeded with vasoactive intestinal peptide gene-transfected mesenchymal stem cells in a rat model. J Neural Eng 11(4): 046024.
  7. Escolano, A., Martinez-Martinez, S., Alfranca, A., Urso, K., Izquierdo, H. M., Delgado, M., Martin, F., Sabio, G., Sancho, D., Gomez-del Arco, P. and Redondo, J. M. (2014). Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. EMBO J 33(10): 1117-1133.
  8. Aguilar, E.*, Cobo, M.* and Martin, F.* (2013). Gene-modified mesenchymal stem cells:A VIP experience. Inflammation & Regeneration 34(4). *Share authorship
  9. Anderson, P., Carrillo-Gálvez, A. B., García-Peréz, A., Cobo, M. and Martín, F. (2013). CD105 (endoglin)-negative murine mesenchymal stromal cells define a new multipotent subpopulation with distinct differentiation and immunomodulatory capacities. PLoS One 8(10): e76979.
  10. Cobo, M., Anderson, P., Benabdellah, K., Toscano, M. G., Muñoz, P., Garcia-Peréz, A., Gutierrez, I., Delgado, M. and Martin, F. (2013). Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis. Cell Transplant 22(5): 839-854.
  11. Toscano, M. G., Anderson, P., Muñoz, P., Lucena, G., Cobo, M., Benabdellah, K., Gregory, P. D., Holmes, M. C. and Martin, F. (2013). Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome. Dis Mod Mech 6(2): 544 - 598.
  12. Tirado-González, I., Muñoz-Fernández, R., Prados, A., Leno-Durán, E., Martin, F., Abadia-Molina, A. C. and Olivares, E. G. (2012). Apoptotic DC-SIGN+ cells in normal human decidua. Placenta 33(4): 257-263.
  13. Ramos-Mejía, V., Fernández, A. F., Ayllón, V., Real, P. J., Bueno, C., Anderson, P., Martín, F., Fraga, M. F. and Menendez, P. (2012). Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification. Stem Cells Dev 21(9): 1549-1558.
  14. Muñoz, P., Toscano, M. G., Real, P. J., Benabdellah, K., Cobo, M., Bueno, C., Ramos-Mejía, V., Menendez, P., Anderson, P. and Martín, F. (2012). Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors. PLoS One 7(6): e39091.
  15. Guadalupe Zaldívar Lelo de Larrea, Martin, F., Carlos Francisco Sosa Ferreyra, Javier Ávila Morales, Miguel Lloret Rivas, Monserrat Román Lara and Genaro Vega Malagón. (2012). Cáncer cérvicouterino y virus del papiloma humano. Revista chilena de obstetricia y ginecología 77(4): 315 - 323.
  16. Toscano, M. G., Romero, Z., Muñoz, P., Cobo, M., Benabdellah, K. and Martin, F. (2011). Physiological and tissue-specific vectors for treatment of inherited diseases. Gene Ther 18(2): 117-127.
  17. Romero, Z., Torres, S., Cobo, M., Muñoz, P., Unciti, J. D., Martin, F.* and Molina, I. J.* (2011). A tissue-specific, activation-inducible, lentiviral vector regulated by human CD40L proximal promoter sequences. Gene Ther 18(4): 364-371.
  18. Benabdellah, K., Cobo, M., Muñoz, P., Toscano, M. G. and Martin, F.* (2011). Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines. PLoS One 6(8): e23734.
  19. Toscano, M. G., Delgado, M., Kong, W., Martin, F., Skarica, M. and Ganea, D. (2010). Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs. Mol Ther 18(5): 1035-1045.
  20. Macias, D., Oya, R., Saniger, L., Martin, F. and Luque, F. (2009). A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cells. Hum Gene Ther 20(11): 1259-1268.
  21. Romero, Z., Toscano, M. G., Unciti, J. D., Molina, I. and Martin, F. (2009). Safer vectors for gene therapy of primary immunodeficiencies. Curr Gene Ther 9(4): 291-305.
  22. Toscano, M. G., Benabdellah, K., Muñoz, P., Frecha, C., Cobo, M. and Martín, F. (2009). Was cDNA sequences modulate transgene expression of was promoter-driven lentiviral vectors. Human Gene Therapy 20(11): 1279-1369.
  23. Frecha, C., Toscano, M. G., Costa, C., Saez-Lara, M. J., Cosset, F. L., Verhoeyen, E. and Martin, F. (2008). Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Ther 15(12): 930-941.
  24. Delgado, M., Toscano, M. G., Benabdellah, K., Cobo, M., O'Valle, F., Gonzalez-Rey, E. and Martín, F. (2008). In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis. Arthritis Rheum 58(4): 1026-1037.
  25. Toscano, M. G., Frecha, C., Benabdellah, K., Cobo, M., Blundell, M., Thrasher, A. J., Garcia-Olivares, E., Molina, I. J. and Martin, F. (2008). Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein. Hum Gene Ther 19(2): 179-197.
  26. Artritis gene therpay by in vivo delivery of lentiviral vectors expressing vasoactive intestinal peptidecDNA. Arthritis Rheu: 1026 - 1038. 2008.
  27. Munoz-Fernandez, R., Blanco, F. J., Frecha, C., Martín, F., Kimatrai, M., Abadía-Molina, A. C., García-Pacheco, J. M. and Olivares, E. G. (2006). Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts. J Immunol 177(1): 280-289.
  28. Sáez-Lara, M. J., Frecha, C., Martín, F., Abadía, F., Toscano, M., Gil, A. and Fontana, L. (2006). Transplantation of human CD34+ stem cells from umbilical cord blood to rats with thioacetamide-induced liver cirrhosis. Xenotransplantation 13(6): 529-535.
  29. Chan, L., Nesbeth, D., Mackey, T., Galea-Lauri, J., Gäken, J., Martin, F., Collins, M., Mufti, G., Farzaneh, F. and Darling, D. (2005). Conjugation of lentivirus to paramagnetic particles via nonviral proteins allows efficient concentration and infection of primary acute myeloid leukemia cells. J Virol 79(20): 13190-13194.
  30. Kimatrai, M., Blanco, O., Muñoz-Fernandez, R., Tirado, I., Martin, F., Abadía-Molina, A. C. and Olivares, E. G. (2005). Contractile activity of human decidual stromal cells. II. Effect of interleukin-10. J Clin Endocrinol Metab 90(11): 6126-6130.
  31. Martin, F., Toscano, M. G., Blundell, M., Frecha, C., Srivastava, G. K., Santamaria, M., Thrasher, A. J. and Molina, I. J. (2005). Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Ther 12(8): 715-723.
    * Senior and corresponding